The Born in Guangzhou Cohort Study (BIGCS)
BIGCS
4 other identifiers
observational
30,000
1 country
1
Brief Summary
The Born in Guangzhou Cohort Study (BIGCS) was established to investigate the short- and long-term effects of exposure in early life on health consequences in Guangzhou, China. Data are collected regarding environmental, occupational and lifestyle exposures as well as health outcomes in later life. Biological samples including blood and tissue samples are also collected from the participants.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Feb 2012
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2012
CompletedFirst Submitted
Initial submission to the registry
August 13, 2015
CompletedFirst Posted
Study publicly available on registry
August 18, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2030
ExpectedFebruary 26, 2024
February 1, 2024
13.9 years
August 13, 2015
February 22, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
Number of participant with pregnancy outcomes
Including abortion, stillbirth, live birth, preterm birth, low birth weight and birth defects
At delivery
Secondary Outcomes (4)
Neurodevelopment during early childhood
At age of 3 years
Weight changes during early childhood
At birth, age of 6 weeks, 6 months, 1 year and 3 years
Height changes during early childhood
At birth, age of 6 weeks, 6 months, 1 year and 3 years
Changes of body composition during early childhood
At birth, age of 6 weeks, 6 months, 1 year and 3 years
Study Arms (1)
No treatment
Interventions
Eligibility Criteria
Pregnant women attending their first routine antenatal examinations (usually around week 16) and their partners and offsrping
You may qualify if:
- Pregnant women with \<20 weeks of gestation
- Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center
- Permanent residents or families intended to remain in Guangzhou with their child for ≥3 years
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Guangzhou Women and Children's Medical Center
Guangzhou, Guangdong, 510623, China
Related Publications (1)
He JR, Yuan MY, Chen NN, Lu JH, Hu CY, Mai WB, Zhang RF, Pan YH, Qiu L, Wu YF, Xiao WQ, Liu Y, Xia HM, Qiu X. Maternal dietary patterns and gestational diabetes mellitus: a large prospective cohort study in China. Br J Nutr. 2015 Apr 28;113(8):1292-300. doi: 10.1017/S0007114515000707. Epub 2015 Mar 30.
PMID: 25821944BACKGROUND
Related Links
Biospecimen
During pregnancy: maternal blood, urine and stool. At delivery: cord, cord blood and placenta. During infancy: dry blood spot, stool and blood. Druing childhood: blood, buccal swab and stool.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Xiu Qiu, PhD
Guangzhou Women and Children's Medical Center, China
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director of the Born in Guangzhou Cohort Study
Study Record Dates
First Submitted
August 13, 2015
First Posted
August 18, 2015
Study Start
February 1, 2012
Primary Completion
December 31, 2025
Study Completion (Estimated)
December 31, 2030
Last Updated
February 26, 2024
Record last verified: 2024-02