Maternal Grandmothers in the Born in Guangzhou Cohort Study

NCT03633162 | Recruiting

• 3 other identifiers: 201804180181673181201508030037
• Study Type: observational
• Target: 5,000
• Locations: 1 country
• Sites: 1

Brief Summary

The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of "grandmother-mother-child" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.

Conditions

Hereditary Transmission; Immune Development; Childhood Obesity; Host and Microbiome; Neurodevelopment

Keywords

Maternal Grandmother; Genes; Immune; Cohort; Child development

Outcome Measures

Primary Outcomes (1)

• Haplotypes transfered by non-inherited maternal antigens from maternal grandmother to female offspring

  Assessed by analyses of MHC haplotypes, HLA haplotypes, and levels of non-inherited maternal antigens of mother and offspring, and pregnancy complication of maternal grandmothers and mothers

  From the date of her daughter get pregnant until the date her grandchild/grandchildren is/are given birth

Secondary Outcomes (7)

• Serum levels of Inflammatory factors at grandchildren's birth and early neonatal life

  At the birth date of her grandchild/grandchildren, at the date 42 days after the birth of the certain grandchild/grandchildren

• The prevalence of eczema of grandchildren

  At the age of 6 weeks, 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren

• The incidence of asthma of grandchildren

  At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren

• The prevalence of Allergic rhinitis of grandchildren

  At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren

• The prevalence of Food allergy of children and grandchildren

  At the age of 6 months, 1year, 3 years, 6 years, 12years and 18years of grandchildren

Eligibility Criteria

• Age: 36 Years - 100 Years
• Gender Eligibility Details: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All maternal grandmothers of the children in the Born in Guangzhou Cohort Study (BIGCS) would be recruited.

You may qualify if:

• Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center
• Baseline information of maternal grandmother's daughter during pregnancy available

You may not qualify if:

• Significant cardiovascular abnormalities
• Intelligent obstacle, intellectual disabilities or gawkish condition

Sponsors & Collaborators

• Guangzhou Women and Children's Medical Center: lead
• Children's Hospital Medical Center, Cincinnati: collaborator
• University of Birmingham: collaborator

Study Sites (1)

Guangzhou Women and Children's Medical Center

Guangzhou, Guangdong, 510623, China

RECRUITING

Related Publications (2)

• Qiu X, Lu JH, He JR, Lam KH, Shen SY, Guo Y, Kuang YS, Yuan MY, Qiu L, Chen NN, Lu MS, Li WD, Xing YF, Zhou FJ, Bartington S, Cheng KK, Xia HM. The Born in Guangzhou Cohort Study (BIGCS). Eur J Epidemiol. 2017 Apr;32(4):337-346. doi: 10.1007/s10654-017-0239-x. Epub 2017 Mar 20.

  PMID: 28321694 BACKGROUND

• Kinder JM, Jiang TT, Ertelt JM, Xin L, Strong BS, Shaaban AF, Way SS. Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells. Cell. 2015 Jul 30;162(3):505-15. doi: 10.1016/j.cell.2015.07.006. Epub 2015 Jul 23.

  PMID: 26213383 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

blood, buccal mucosal cells, stool, urine, fingernail and hair

MeSH Terms

Conditions

Pediatric Obesity

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Xiu Qiu, PhD

  Guangzhou Women and Children's Medical Center, China

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Xiu Qiu, PhD

CONTACT

0086 20 38367160; qxiu0161@163.com

Xueling Wei, MS

CONTACT

0086 20 38367159; xueling.wei@bigcs.org

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of the Born in Guangzhou Cohort Study

Study Record Dates

• First Submitted: July 23, 2018
• First Posted: August 16, 2018
• Study Start: May 21, 2018
• Primary Completion: December 31, 2025
• Study Completion (Estimated): December 31, 2038
• Last Updated: October 1, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)