Cognitive Training in Patients With MCI Using fMRI

NCT03263247 | Active Not Recruiting DMC

• 1 other identifier: MCI cognitive training
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The current project aims to investigate the trajectories of the visual imaging cognitive training (CT) and alphabet search training using fMRI in patients with amnestic mild cognitive impairment (MCI) and healthy elderly controls (HE). MCI patients will be grouped according to biomarkers (PET PIB).

Conditions

Mild Cognitive Impairment

Outcome Measures

Primary Outcomes (1)

• Results from task performance in functional magnetic resonance imaging (fMRI)

  fMRI behavioral performance

  Baseline, after CT, and 12 months later

Secondary Outcomes (1)

• Changes in cognitive measures and brain activation

  Baseline, after CT e 12 months follow-up

Study Arms (1)

Visual Imaging Training

EXPERIMENTAL

Participants will receive visual imaging training to facilitate learning of written information. Intervention: Visual Imaging Training in individual sessions

Behavioral: Visual Memory Training; Behavioral: Alphabet search

Interventions

Alphabet search BEHAVIORAL

Visual Imaging Training

Visual Memory Training BEHAVIORAL

In the first phase of the study all participants will receive visual memory training. In the second phase they will receive alphabetic search training

Visual Imaging Training

Eligibility Criteria

• Age: 60 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Portuguese as native and preferred language; A minimum of 4 years of education; MRI-compatible; Right-handed individuals; Normal corrected vision and hearing; Estimated intelligence average or above (≥ 80 IQ);

You may not qualify if:

• History of neurological disorder, severe mental illness; Current untreated alcohol or substance abuse; Medical conditions that compromise in any way the central nervous system; Presence of visual impairment and / or hearing to preclude cognitive testing; Presence of contraindications to MRI exam; Findings in structural MRI that can interfere with the results of the study

Sponsors & Collaborators

• São Paulo State University: lead
• Ricardo Nitrini: collaborator
• Sonia Brucki: collaborator
• Edson Amaro Junior: collaborator
• Maria da Graca M Martin: collaborator
• Aline Gisele Gonçalves: collaborator
• Letícia Ferreira da Mota: collaborator
• Isabella Maria Bello Avolio: collaborator
• Rodolfo dos Anjos: collaborator
• Camila Carneiro Pedroza: collaborator
• Ana Carolina Cruz: collaborator
• Leticia Nery Celino de Souza Pak: collaborator
• Paulo Rodrigo Bazán: collaborator
• Maira Okada de Oliveira: collaborator

Study Sites (1)

University of Sao Paulo

São Paulo, São Paulo, 05403000, Brazil

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr Eliane C Miotto

Study Record Dates

• First Submitted: August 24, 2017
• First Posted: August 28, 2017
• Study Start: January 2, 2017
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: August 24, 2026

Record last verified: 2026-08

Locations

BR (1)