Memory Training Versus Yogic Meditation Training in Older Adults With Mild Cognitive Impairment

NCT01983930 | Completed Results DMC

• 1 other identifier: 13-000821
• Study Type: interventional
• Target: 81
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this pilot study is to test whether 6 months of supervised weekly Kundalini yoga classes and a brief daily meditation homework assignment can improve memory and thinking in older adults with mild memory complaints when compared to weekly classes of memory training with daily homework assignments.

Conditions

Mild Cognitive Impairment

Keywords

Memory impairment; Meditation; Yoga; memory training; Mild cognitive impairment; MCI; geriatric; fMRI

Outcome Measures

Primary Outcomes (1)

• Cognitive Measures - Hopkins Verbal Learning Test (HVLT) Total Recall Score

  Primary outcome measures were administered by a cognitive battery of neuropsychological and included memory and executive functioning. Verbal memory was measured with the Hopkins Verbal Learning Test (HVLT) total recall scores. The HVLT form contains 12 nouns, four words each from one of three semantic categories (e.g., precious gems, articles of clothing, vegetables, etc.), to be learned over the course of three learning trials. When scoring the HVLT, the three learning trials are combined to calculate a total recall score. Total scores range from 0-36 with higher scores indicating better outcome.

  At baseline and at 6 months

Secondary Outcomes (3)

• Clinical Global Impression Scale

  Baseline, weeks 2, 4, 6, 8, 10, 12, 24

• Geriatric Depression Scale (GDS)

  Baseline and Week 24

• Change in Functional Magnetic Resonance Imaging (fMRI) Connectivity

  12 weeks

Study Arms (2)

Memory Training

ACTIVE COMPARATOR

Group memory training will be administered for amnestic mild cognitive impairment (MCI)

Behavioral: Memory Training

Kundalini yoga and meditation

EXPERIMENTAL

Participants will engage in weekly yoga classes and daily 20 minute meditation

Behavioral: Kundalini yoga and meditation

Interventions

Kundalini yoga and meditation BEHAVIORAL

Participants will participate in a 60 minute yoga and meditation session weekly for 12 weeks and will be assigned a daily Kirtan Kriya meditation (12 minute duration) for 12 weeks.

Kundalini yoga and meditation

Memory Training BEHAVIORAL

Participants will attend a weekly memory training class for 12 weeks as well as receive daily memory homework (12 minute duration) for the 12 weeks.

Memory Training

Eligibility Criteria

• Age: 55 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Mild cognitive impairment amnestic type
• Clinical Dementia Rating scale score of 0.5
• SufficientEnglish proficiency and 8th grade or higher reading level as determined by the word reading subtest of the Wide Range Achievement Test-IV
• Capacity to provide informed consent.

You may not qualify if:

• Any current or past psychiatric disorders, or recent unstable medical or neurological disorders
• Any disabilities preventing their participation in the memory enhancement training (MET) (e.g. severe visual or hearing impairment)
• Insufficient English proficiency
• Diagnosis of dementia
• Mini Mental Health Examination score of 24 and below
• Psychoactive medications
• Participation in a psychotherapy that involves cognitive training
• Do not meet criteria for Mild cognitive impairment subtype
• Prior or current training in yoga.

Sponsors & Collaborators

• University of California, Los Angeles: lead

Study Sites (1)

UCLA Semel Institute

Los Angeles, California, 90095, United States

Location

Related Publications (1)

• Eyre HA, Siddarth P, Acevedo B, Van Dyk K, Paholpak P, Ercoli L, St Cyr N, Yang H, Khalsa DS, Lavretsky H. A randomized controlled trial of Kundalini yoga in mild cognitive impairment. Int Psychogeriatr. 2017 Apr;29(4):557-567. doi: 10.1017/S1041610216002155. Epub 2017 Jan 16.

  PMID: 28088925 DERIVED

MeSH Terms

Conditions

Cognitive Dysfunction; Memory Disorders

Interventions

Meditation; Cognitive Training

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Mind-Body Therapies; Complementary Therapies; Therapeutics; Spiritual Therapies; Relaxation Therapy; Behavior Therapy; Psychotherapy; Behavioral Disciplines and Activities; Neurological Rehabilitation; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Health Services; Health Care Facilities Workforce and Services

Results Point of Contact

• Title: Helen Lavretsky, M.D.
• Organization: UCLA

hlavretsky@mednet.ucla.edu

310-794-4619

Study Officials

• Helen Lavretsky, MD, MS

  UCLA Semel Institute

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: October 30, 2013
• First Posted: November 14, 2013
• Study Start: September 1, 2013
• Primary Completion: May 1, 2016
• Study Completion: May 1, 2016
• Last Updated: October 23, 2018
• Results First Posted: October 23, 2018

Record last verified: 2017-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)