Build-up of Action Representation in Autism Spectrum Disorders

NCT03108976 | Completed

• 1 other identifier: 69HCL16_0677
• Study Type: interventional
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

Autistic spectrum disorders (ASD) are highly debilitating developmental syndromes which core feature is social and communications disorders. Motor skill impairments are frequently described in autism, but few studies have addressed the question of their origin and their specificity. Furthermore, it is not clear whether motor problems encountered in autism are related to dyspraxia, or if they present with specific features. This project aims at deciphering the origin of motor problems encountered by children who grow-up with autism in order to propose early interventions that could influence the other developmental trajectories, such as the social one. Brain dynamics during sensori-motor learning is explored by applying magnetoencephalography (MEG) during the Bimanual Load-Lifting paradigm. Different motor processes namely: proprioceptive monitoring, use and update of a sensori-motor representation, anticipatory executive control will be correlated to brain oscillation modulation, both topographically and temporally. Two groups of children (aged between 7 and 12) are compared: a group of children with ASD and a control group of typically developing children.

Conditions

Healthy; Autism Spectrum Disorder

Keywords

Autism; Sensori-motor learning; Development; Neuroimaging

Outcome Measures

Primary Outcomes (1)

• Changes of cerebral oscillations in three frequency bands (alpha, beta, gamma) during sensori-motor learning.

  Oscillatory measures are computed in the sensor and source space in order to identify the regions involved in the sensori-motor learning in the control group and in the ASD group.

  Day 1

Secondary Outcomes (1)

• Correlation between oscillatory measures and learning performance.

  Day 1

Study Arms (2)

Control group

SHAM COMPARATOR

Children with a typical development.

Other: Behavioral assessments; Other: Magnetoencephalography (MEG); Other: Magnetic Resonance Imaging (MRI)

Case group

ACTIVE COMPARATOR

Children with Autism Spectrum Disorders.

Other: Behavioral assessments; Other: Magnetoencephalography (MEG); Other: Magnetic Resonance Imaging (MRI)

Interventions

Behavioral assessments OTHER

Kinematics measures, concomitant to Magnetoencephalography (MEG, measures oscillatory rhythms in the brain) and Magnetic Resonance Imaging (MRI, used to provide an anatomical image of each participant's brain to be coregistered with oscillatory measurements) recordings, enable to track sensori-motor learning based on performance, and oscillatory changes (with high temporal and spatial resolution).

Case group; Control group

Magnetoencephalography (MEG) OTHER

Kinematics measures, concomitant to Magnetoencephalography (MEG, measures oscillatory rhythms in the brain) and Magnetic Resonance Imaging (MRI, used to provide an anatomical image of each participant's brain to be coregistered with oscillatory measurements) recordings, enable to track sensori-motor learning based on performance, and oscillatory changes (with high temporal and spatial resolution).

Case group; Control group

Magnetic Resonance Imaging (MRI) OTHER

Kinematics measures, concomitant to Magnetoencephalography (MEG, measures oscillatory rhythms in the brain) and Magnetic Resonance Imaging (MRI, used to provide an anatomical image of each participant's brain to be coregistered with oscillatory measurements) recordings, enable to track sensori-motor learning based on performance, and oscillatory changes (with high temporal and spatial resolution).

Case group; Control group

Eligibility Criteria

• Age: 7 Years - 12 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Control group: children aged between 7 and 12
• Case group: children aged between 7 and 12 with a diagnostic of Autism Spectrum Disorders

You may not qualify if:

• Control group: presence of a neurological pathology, mental retardation or language and motor developmental delay
• Case group: presence of a neurological pathology, mental retardation

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

CH le Vinatier

Bron, 69500, France

Location

MeSH Terms

Conditions

Autism Spectrum Disorder; Autistic Disorder

Interventions

Magnetoencephalography; Magnetic Resonance Spectroscopy

Condition Hierarchy (Ancestors)

Child Development Disorders, Pervasive; Neurodevelopmental Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Neurological; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis; Magnetometry; Investigative Techniques; Spectrum Analysis; Chemistry Techniques, Analytical

Study Officials

• Sandrine SONIE, MD

  CH le Vinatier

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 30, 2017
• First Posted: April 11, 2017
• Study Start: April 10, 2015
• Primary Completion: December 31, 2018
• Study Completion: December 31, 2018
• Last Updated: August 26, 2022

Record last verified: 2022-08

Locations

FR (1)