NCT03095794

Brief Summary

The purpose of this study is to investigate neural mechanism of healthy humans underlying group decision making and compare it with that of individual decision-making. Using functional neuroimaging technology combining with computational modeling, we examine how the human brain process social information to make a decision within a group, which often guides humans to make a better decision using collective wisdom.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
145

participants targeted

Target at P75+ for not_applicable healthy

Timeline
Completed

Started Jan 2015

Typical duration for not_applicable healthy

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 31, 2015

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 18, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 18, 2016

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

March 24, 2017

Completed
6 days until next milestone

First Posted

Study publicly available on registry

March 30, 2017

Completed
Last Updated

November 28, 2017

Status Verified

November 1, 2017

Enrollment Period

1.5 years

First QC Date

March 24, 2017

Last Update Submit

November 24, 2017

Conditions

Outcome Measures

Primary Outcomes (1)

  • Brain activation associated with decision-making (fMRI, non-invasive measure)

    1 hour in a fMRI scanner

    Day 1

Study Arms (1)

neural mechanisms of decision making

EXPERIMENTAL

Previous studies on how brain manages a value-based decision have been bounded to individual decisions. The current study will extend the understanding of social dimensions by answering four questions.

Other: How people learn another's value preference during decision under riskOther: Neural mechanism of making a group decision under risk that influences on in-group membersOther: Neural mechanism of making a group decision that influences on out-group membersOther: fMRI

Interventions

The aim of this study is to investigate how an agent learns another's value preference when they should make decisions on behalf of another. This experiment consists of 3 parts(i) measuring individual's loss aversion; (ii) feedback based learning of another's value preference; (iii) and decisions on behalf of others.

neural mechanisms of decision making

how individuals evaluate the risk and the outcome when they should make a single agreement decision in a group that will influence every member's payoff regardless of individuals' decisions. For the first part of the experiment, we will measure the individual level of loss aversion which will be used as the parameter for controlling individual differences.

neural mechanisms of decision making

Human is decimated with other species by delegation of one responsibility. Although the person who has no-interests with the outcome of decision, they should make a delegated decision. Therefore, this decision has influences on others who are not part of the group. The third party punishment (Juries decision making) is one example of the decision made by a group influencing the out group members.

neural mechanisms of decision making
fMRIOTHER

For neuroimaging passes, the expected duration of each of the experimental protocols is about 1h30 for tasks 1 and 2 and about 2h for task 3. The maximum period foreseen for neuroimaging tests is 3 years and will start as soon as possible. Completion of the behavioral tests.

neural mechanisms of decision making

Eligibility Criteria

Age20 Years - 30 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • healthy human adult
  • normal vision

You may not qualify if:

  • depression
  • potential addiction to alcohol/ nicotine

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CH le Vinatier

Bron, 69500, France

Location

Study Officials

  • Caroline DEMILY, MD

    CH le Vinatier

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 24, 2017

First Posted

March 30, 2017

Study Start

January 31, 2015

Primary Completion

July 18, 2016

Study Completion

July 18, 2016

Last Updated

November 28, 2017

Record last verified: 2017-11

Locations