Cognitive Control of Language

NCT03124173 | Completed

• 1 other identifier: 69HCL16_0684
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

The cognitive control of speech is central to human social communication. Two frontal brain regions seem to have a critical role: 1) Broca's area (BA) and 2) the mid-cingulate cortex (MCC). Current rehabilitation strategy is clearly based on therapies promoting language performance. However, there is few evidence that rehabilitation strategies based on nonlinguistic aspects of brain function may enhance recovery. Such strategies may benefit from knowledge about the primary -nonlinguistic- function of the BA-MCC network. The aim of LANGUAGE is to identify this primary function. One hypothesis is that, in non-speaking primates, this network is involved in cognitive control of voluntary vocal/orofacial production. Specifically, whereas BA may be responsible for the high-level selection of orofacial and vocal responses during learning, the face motor representation within the MCC may be responsible for performance monitoring, a process inherently required in learning. LANGUAGE aims to test this hypothesis by determining in human the anatomo-functional organization of the BA-MCC network thanks to functional magnetic resonance imaging (fMRI).

Conditions

Healthy

Keywords

fMRI; cingulate cortex; adaptation; frontal cortex

Outcome Measures

Primary Outcomes (2)

• Behavioral data: performance in the task

  Performance in the task will be assessed. If performance in the task is \<80%, subjects will be excluded in the final analysis

  3 years

• fMRI data

  BOLD signal will be analyzed in relation to the events of the task. Images must be not too much distorted to allow data analysis. As such, if a subject moved too much (translation\>10mm; rotation\>5°) the corresponding data will be excluded from the analysis.

  3 years

Study Arms (1)

Behavioral Tasks

OTHER

Each subject will conduct 4 sessions, i.e. a training session and three fMRI sessions. The first session will consist in training the subject to carry out the different behavioral tasks that he will then have to perform during the sessions of fMRI.

Other: Training session; Other: First fMRI session; Other: Second fMRI session; Other: Third session of fMRI

Interventions

Training session OTHER

The subjects will be trained to realize several versions of a learning task of conditional visuo-motor associations.

Behavioral Tasks

First fMRI session OTHER

In this session (involving a condition specific to man and a condition that we are certain to obtain in the monkey), subjects will have to learn by trial and error during successive trials, the conditional associations between three abstract stimuli and three Manual responses (3 MRI-compatible mouse buttons).

Behavioral Tasks

Second fMRI session OTHER

In this session (involving a condition specific to man and a condition that we are almost certain to obtain in monkeys), subjects will have to learn by trial and error during successive trials, the conditional associations between three abstract stimuli and Three orofacial responses (3 movements of the mouth).

Behavioral Tasks

Third session of fMRI OTHER

In this session (involving a human-specific condition and a condition we hope to achieve in the monkey), subjects will have to learn by trial-error in successive trials, conditional associations between three abstract stimuli and three verbal or Vocals.

Behavioral Tasks

Eligibility Criteria

• Age: 20 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• being able to provide a written consent form
• having a social insurance
• have a normal vision (with or without corrections)
• Right-handed

You may not qualify if:

• Subjects with MRI contraindications (e.g. pacemaker, claustrophobia, metal in the body, etc…).
• Subjects must be willing to be advise in case of discovery of brain abnormality.
• History of known neurological or psychiatric illness
• Pregnant or nursing women
• Persons under guardianship, curators or any other administrative or judicial measure of deprivation of rights

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Hôpital Henri Mondor

Créteil, 94000, France

Location

Related Publications (3)

• Loh KK, Procyk E, Neveu R, Lamberton F, Hopkins WD, Petrides M, Amiez C. Cognitive control of orofacial motor and vocal responses in the ventrolateral and dorsomedial human frontal cortex. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4994-5005. doi: 10.1073/pnas.1916459117. Epub 2020 Feb 14.

  PMID: 32060124 BACKGROUND

• Loh KK, Hadj-Bouziane F, Petrides M, Procyk E, Amiez C. Rostro-Caudal Organization of Connectivity between Cingulate Motor Areas and Lateral Frontal Regions. Front Neurosci. 2018 Jan 11;11:753. doi: 10.3389/fnins.2017.00753. eCollection 2017.

  PMID: 29375293 BACKGROUND

• Hillis AE. Magnetic resonance perfusion imaging in the study of language. Brain Lang. 2007 Aug;102(2):165-75. doi: 10.1016/j.bandl.2006.04.016. Epub 2006 Jun 6.

  PMID: 16757020 BACKGROUND

Study Officials

• Philippe Domenech, MD

  Henri Mondor University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 9, 2017
• First Posted: April 21, 2017
• Study Start: January 14, 2015
• Primary Completion: May 19, 2016
• Study Completion: May 19, 2016
• Last Updated: September 9, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)