Sleep Inertia and Functional Connectivity
1 other identifier
interventional
55
1 country
1
Brief Summary
The aim of the study is to investigate the functional connectivity between the brain regions of the default mode network before and after a 40 min nap slot in the afternoon. The hypothesis is that connectivity between brain regions will be decreased after the nap as compared to before the nap.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable healthy
Started Mar 2015
Longer than P75 for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 5, 2015
CompletedFirst Submitted
Initial submission to the registry
February 9, 2017
CompletedFirst Posted
Study publicly available on registry
February 20, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 24, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
July 3, 2017
CompletedSeptember 3, 2025
August 1, 2025
2.2 years
February 9, 2017
August 26, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Measure: Change of correlation values between the BOLD (Blood Oxygenation Level Dependent) signal time series of the brain regions of the default mode network (DMN) between the scans before and after the nap slot.
The hypothesis is that connectivity between the brain regions of the default mode network will be decreased after the nap as compared to before the nap and that it will be more the case for subjects with a high dream recall frequency as compared to subjects with a law dream recall frequency. fMRI scans will be acquired before and after a 40 min nap slot in the afternoon. Functional connectivity between brain region will be assessed analyzing the scans with the functional connectivity toolbox (CONN) of the Statistical Parametric Mapping (SPM) software.
fMRI scans will be acquired 5 min before, 5 min after and 25min after the nap slot.
Study Arms (2)
Subjects with a high dream recall frequency
OTHERSubjects with a law dream recall frequency
OTHERInterventions
fMRI scans will be acquired before and after a 40 min nap slot in the afternoon. Functional connectivity between brain region will be assessed analyzing the scans with the CONN toolbox of the Statistical Parametric Mapping (SPM) software.
Eligibility Criteria
You may qualify if:
- \> age \> 18
- high or law dream recall frequency
You may not qualify if:
- history of psychiatric or neurologic or sleep pathologies
- counter indication for MRI
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
CH le VINATIER
Bron, 69500, France
Related Publications (1)
Vallat R, Meunier D, Nicolas A, Ruby P. Hard to wake up? The cerebral correlates of sleep inertia assessed using combined behavioral, EEG and fMRI measures. Neuroimage. 2019 Jan 1;184:266-278. doi: 10.1016/j.neuroimage.2018.09.033. Epub 2018 Sep 14.
PMID: 30223060BACKGROUND
Study Officials
- PRINCIPAL INVESTIGATOR
Alain NICOLAS, MD
CH le VINATIER
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 9, 2017
First Posted
February 20, 2017
Study Start
March 5, 2015
Primary Completion
May 24, 2017
Study Completion
July 3, 2017
Last Updated
September 3, 2025
Record last verified: 2025-08
Data Sharing
- IPD Sharing
- Will not share