SLeep and IMagery Correlates (SOMMEIL-IMAGERIE)

NCT03130322 | Completed

• 1 other identifier: 69HCL16_0676
• Study Type: interventional
• Target: 51
• Locations: 1 country
• Sites: 1

Brief Summary

This study is designed to determine the neural networks underlying the sleep-related motor consolidation process following motor imagery practice. While beneficial effects of sleep are expected for sequential movement but not for adaptation motor tasks, the corresponding neuroanatomical correlates have not yet been investigated when participants acquired the motor tasks through mental practice. Data should substantially promote how designing motor imagery interventions targeting (re)learning and/or motor recovery in patients suffering from motor disorders.

Conditions

Healthy

Outcome Measures

Primary Outcomes (2)

• Evidence of MEG correlates of sleep motor consolidation (day 1)

  The investigator will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.

  Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)

• Evidence of MEG correlates of sleep motor consolidation (day 2)

  The investigator will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.

  Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)

Secondary Outcomes (5)

• Time needed to complete the motor tasks (day 1)

  Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)

• Evidence of MEG correlates of sleep motor consolidation

  Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)

• Accuracy of the motor tasks

  Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)

• Time needed to complete the motor tasks

  Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)

• Accuracy of the motor tasks 2

  Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)

Study Arms (4)

NightPP

EXPERIMENTAL

Participants of the NightPP will be subjected to one MRI session and two MEG recording sessions: the first one before a physical practice session of the two motor tasks investigated in the study, and second MEG session right after practice.

Other: Imagery and Sleep questionnaires; Other: MEG recordings (pre-test); Other: Practice session; Other: MEG recordings (Post-test); Other: MRI

NightMI

EXPERIMENTAL

Participants of the NightMI will be subjected to one MRI session and two MEG recording sessions: the first one before a motor imagery practice session of the two motor tasks investigated in the study, and second MEG session right after practice.

Other: Imagery and Sleep questionnaires; Other: MEG recordings (pre-test); Other: Practice session; Other: MEG recordings (Post-test); Other: MRI

NightCtrl

EXPERIMENTAL

Participants of the NightCtrl will be subjected to one MRI session and two MEG recording sessions: the first one before a mental rotation practice session, a second MEG session right after practice,and second MEG session right after practice.

Other: Imagery and Sleep questionnaires; Other: MEG recordings (pre-test); Other: Practice session; Other: MEG recordings (Post-test); Other: MRI

Day

EXPERIMENTAL

Participants of the NightMI will be subjected to one MRI session and two MEG recording sessions: the first one before a motor imagery practice session of the two motor tasks investigated in the study, and second MEG session right after practice.

Other: Imagery and Sleep questionnaires; Other: MEG recordings (pre-test); Other: Practice session; Other: MEG recordings (Post-test); Other: MRI

Interventions

Imagery and Sleep questionnaires OTHER

Participants complete a motor imagery questionnaire to assess their ability to form vivid mental images, as well as sleep questionnaires to control the quality of their sleep

Day; NightCtrl; NightMI; NightPP

MEG recordings (pre-test) OTHER

Participants of the Day group perform two motor tasks (a finger sequential motor task and an adaptation motor task using a trackball) in the MEG, during a pre-test (Day 1 - 9h). Task 1: Participants perform an 8-digit motor sequential task where each finger (except the thumb) is used twice. Performance is assessed by using a 4-keys keyboard. Participants are required to keep their fingers on the keys to minimize amplitude are instructed to tap the sequence as few errors as possible Task 2: Participants perform a motor adaptation task requiring scrolling a trackball to superimpose a geometric shape on another one, strictly similar but presented from another angle, as fast as possible.

Day; NightCtrl; NightMI; NightPP

Practice session OTHER

Participants of the Day group perform a block of motor imagery practice of the two motor tasks.

Day; NightCtrl; NightMI; NightPP

MEG recordings (Post-test) OTHER

Participants perform the two motor tasks in the MEG (post-test, strictly similar to the pre-test)

Day; NightCtrl; NightMI; NightPP

MRI OTHER

The registration of the brain anatomy of each participant will be done by MRI 3D / T the week before the first experimental session.

Day; NightCtrl; NightMI; NightPP

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy right-handed persons without neurologic disease
• Persons having signed informed consent for a neuroimagery study

You may not qualify if:

• Persons under curatorship or any administrative/judicial measure
• Participants refusing to be informed of the results of the experiment
• Pregnant women
• Participants with contraindications to the MEG examination: head size, presence of a neurostimulator, steel pivot for the root canal, metallic fragments, ear implants, metal screws in the body or mouth.
• Persons using a pacemaker, insulin pump, or working regularly with iron filings
• Claustrophobic persons

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

CH le Vinatier

Bron, 69500, France

Location

Related Publications (1)

• Di Rienzo F, Debarnot U, Daligault S, Delpuech C, Doyon J, Guillot A. Brain plasticity underlying sleep-dependent motor consolidation after motor imagery. Cereb Cortex. 2023 Nov 27;33(23):11431-11445. doi: 10.1093/cercor/bhad379.

  PMID: 37814365 BACKGROUND

Study Officials

• Alain Nicolas, MD

  CH le Vinatier

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 10, 2017
• First Posted: April 26, 2017
• Study Start: December 9, 2015
• Primary Completion: December 9, 2017
• Study Completion: July 4, 2018
• Last Updated: September 15, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)