NCT03058133

Brief Summary

Bayesian models of perception represent a promising approach to describe information processing by the brain. Predictive coding hypothesizes a process in which top-down expectations are continuously compared across multiple hierarchical levels with bottom-up sensory inputs and the differences or error signals are propagated in a bottom-up direction. The investigators hypothesize that strong expectations, are best investigated in expert processes such as face and voice recognition in humans. Individuals in complex social systems need to extract socially relevant information in a fast and efficient manner; hence, the majority of humans constitute face, voice and gender experts. Nevertheless, linking such combined abilities to brain activity with regards to the predictive coding hypothesis has not been attempted.Our results suggest asymmetric contributions of visual and auditory signals to the gender classification task. This sensitive psychophysical procedure is implemented in a decoding approach using fMRI and multi-voxel pattern analysis (MVPA). The investigators plan to test whether cortical areas implicated in processing auditory and visual gender signals show similar asymmetries.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
38

participants targeted

Target at P25-P50 for not_applicable healthy

Timeline
Completed

Started May 2016

Longer than P75 for not_applicable healthy

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 20, 2016

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

February 8, 2017

Completed
12 days until next milestone

First Posted

Study publicly available on registry

February 20, 2017

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 28, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 28, 2018

Completed
Last Updated

September 15, 2025

Status Verified

September 1, 2025

Enrollment Period

2 years

First QC Date

February 8, 2017

Last Update Submit

September 9, 2025

Conditions

Healthy

Keywords

fMRI, perception, face-voice processing

Outcome Measures

Primary Outcomes (2)

  • Identify neural correlates (fMRI) of face / voice interaction in a gender classification task

    Classical functional analyses (GLM) and advanced statistical analyses of brain activations (BrainVoyager and Matlab softwares).

    Maximum 90 days between inclusion of the subject and the 1st fMRI session (1h1 / 2). Then maximum 90 days before the 2nd session (1h1 / 2).

  • Identify neural correlates (fMRI) of face / voice respective contribution in a gender classification task

    Classical functional analyses (GLM) and advanced statistical analyses of brain activations

    Maximum 90 days between inclusion of the subject and the 1st fMRI session (1h1 / 2). Then maximum 90 days before the 2nd session (1h1 / 2).

Study Arms (1)

fMRI study

OTHER
Other: fMRI study

Interventions

fMRI studyOTHER

Functional brain activations of face-voice processing during a gender task

fMRI study

Eligibility Criteria

Age18 Years - 40 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy men and women, right-handed
  • No neurological antecedent
  • Signed informed consent

You may not qualify if:

  • Pregnant women
  • Volunteers with MRI contraindications: persons using a pacemaker or insulin pump, persons with a metallic prosthesis or an intracerebral clip, as well as claustrophobic subjects, neurosensory stimulator or implantable defibrillator, cochlear implants, body Foreign ferromagnetic ocular or cerebral close to nerve structures, agitation of the subject (non-cooperating or agitated subjects), ventriculoperitoneal neurosurgical bypass valves, dental apparatus.
  • Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of rights or liberty, as well as persons of legal age protected by law.
  • Participants refusing to be informed of the possible detection of an anomaly.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Le VINATIER

Bron, 69 500, France

Location

Related Publications (8)

  • Abbatecola C, Kennedy H, Knoblauch K. Directed attention influences optimality of top-down and bottom-up multi-modal perceptual integration. Sci Rep. 2025 Jul 16;15(1):25742. doi: 10.1038/s41598-025-09542-6.

    PMID: 40670460BACKGROUND

  • Abbatecola C, Gerardin P, Beneyton K, Kennedy H, Knoblauch K. The Role of Unimodal Feedback Pathways in Gender Perception During Activation of Voice and Face Areas. Front Syst Neurosci. 2021 May 28;15:669256. doi: 10.3389/fnsys.2021.669256. eCollection 2021.

    PMID: 34122023BACKGROUND

  • Gerardin P, Kourtzi Z, Mamassian P. Prior knowledge of illumination for 3D perception in the human brain. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16309-14. doi: 10.1073/pnas.1006285107. Epub 2010 Aug 30.

    PMID: 20805488BACKGROUND

  • Wacongne C, Changeux JP, Dehaene S. A neuronal model of predictive coding accounting for the mismatch negativity. J Neurosci. 2012 Mar 14;32(11):3665-78. doi: 10.1523/JNEUROSCI.5003-11.2012.

    PMID: 22423089BACKGROUND

  • Pegado F, Comerlato E, Ventura F, Jobert A, Nakamura K, Buiatti M, Ventura P, Dehaene-Lambertz G, Kolinsky R, Morais J, Braga LW, Cohen L, Dehaene S. Timing the impact of literacy on visual processing. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5233-42. doi: 10.1073/pnas.1417347111. Epub 2014 Nov 24.

    PMID: 25422460BACKGROUND

  • Markov NT, Ercsey-Ravasz M, Van Essen DC, Knoblauch K, Toroczkai Z, Kennedy H. Cortical high-density counterstream architectures. Science. 2013 Nov 1;342(6158):1238406. doi: 10.1126/science.1238406.

    PMID: 24179228BACKGROUND

  • Charrier C, Knoblauch K, Maloney LT, Bovik AC, Moorthy AK. Optimizing multiscale SSIM for compression via MLDS. IEEE Trans Image Process. 2012 Dec;21(12):4682-94. doi: 10.1109/TIP.2012.2210723. Epub 2012 Jul 30.

    PMID: 22868568BACKGROUND

  • Gerardin P, Devinck F, Dojat M, Knoblauch K. Contributions of contour frequency, amplitude, and luminance to the watercolor effect estimated by conjoint measurement. J Vis. 2014 Apr 10;14(4):9. doi: 10.1167/14.4.9.

    PMID: 24722563BACKGROUND

Study Officials

  • Alain NICOLAS, MD

    Le VINATIER

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 8, 2017

First Posted

February 20, 2017

Study Start

May 20, 2016

Primary Completion

May 28, 2018

Study Completion

May 28, 2018

Last Updated

September 15, 2025

Record last verified: 2025-09

Data Sharing

IPD Sharing
Will not share

Locations

FR(1)