Altruistic Decisions

NCT03116581 | Terminated

• 1 other identifier: 69HCL16_0680
• Study Type: interventional
• Target: 159
• Locations: 1 country
• Sites: 1

Brief Summary

The study aimed to understand how payoffs for others influence perceptual decision making. The research consists in testing how varying monetary payoffs for another modify the perceptual decision making processes. The use of drift diffusion models on a random dots task enable the characterization of the decision parameter(s) that are modulated when a decision is made to win payoffs for others as compared to decisions for self-benefits. Once the parameter revealed through behavioral experiment, neuroimaging is applied to find the neural correlates of the effects of taking others into account in the decision making process.

Conditions

Healthy

Keywords

Perceptual Decision; Social Cognition; Motivation

Outcome Measures

Primary Outcomes (2)

• Modulation of the decisional parameter by the payoff conditions

  behavioral data (reaction-times and accuracy) are collected and the decision parameter can be estimated from them using Drift Diffusion Models

  1 hour

• Modulation of the decisional parameter by the beneficiary conditions

  behavioral data (reaction-times and accuracy) are collected and the decision parameter can be estimated from them using Drift Diffusion Models

  1 hour

Secondary Outcomes (3)

• Event-Related potentials

  1 hour

• Time-frequency brain responses

  1 hour

• BOLD

  1 hour

Study Arms (2)

Vicarious reward

OTHER

If a decision influences the well-being of another (through monetary payoff), the decision making processes should differ from a decision that would influences only oneself. The difference will be reflected in the reaction-times and in the accuracy of the response to the task. The drift diffusion models care then used to estimate le decision parameter in each condition and understand which parameter is influenced by the beneficiary of the payoff associated with a decision. Once the decision parameter characterized with behavioral experiment, the study aims to better understand the neural network sustaining the influence of others on the decision making process, by assessing the neural activity related to the decision making processes. Also, the research compares how the brain responses for payoff for others and payoffs for oneself, specially to confirm that these responses are located in different areas of the Anterior cingulate Cortex.

Other: Behavior; Other: fMRI (functional Magnetic Resonance Imagery); Other: MEG (MagnetoEncephaloGraphy)

Audience effect

OTHER

In order to clarify the complex changes in the decision-making processes induced by simple observation by others (audience) , the experiment have two levels of difficulty . These levels of difficulty will be determined in such a way as to achieve better 'public' performance than 'private' when the task is easy (high level of consistency) and poor performance when the task is difficult (low level of coherence) As described in the literature in psychology. Drift diffusion models will be used to better understand the variations in performance, to decipher between a modulation of the diffusion velocity and or of the decision threshold. This study will help characterize how observation by others modulates performance. Once the decision parameter characterized with behavioral experiment, the study aims to better understand the neural network sustaining the impact of observation by others on the decision making process.

Other: Behavior; Other: fMRI (functional Magnetic Resonance Imagery); Other: MEG (MagnetoEncephaloGraphy)

Interventions

Behavior OTHER

Random-dots tasks: dots appear and move, most have a random trajectory but a given proportion of them move coherently to the same direction. * Vicarious reward Each trial begins with a cue, showing 'me' or 'him' and filled rectangle filled proportionally to the payoff. The cue and the square are depicted in yellow (oneself) or blue (other), depending on the beneficiary. The moving dots are then presented and the subjects respond. At the end of dots motion, the feedback is presented. If the response was correct, a pile of coins proportional to the payoff is shown. For incorrect responses and misses, a red-colored cross is displayed. * Audience effect Each trial begins with the display of two eyes (public) or a padlock (private). The moving dots are shown and the participant answers. Audience condition changes the information available on accuracy when submitting comments. In the observed condition, an arrow shows the response. In the observed condition, no feedback is displayed.

Audience effect; Vicarious reward

fMRI (functional Magnetic Resonance Imagery) OTHER

Both behavioral task (audience effect and vicarious reward) will be studied in fMRI (functional Magnetic Resonance Imagery). The same paradigms used in the behavioral experiment will be adapted for fMRI. Audience Effect experiment: trials will last for 10 seconds maximum. With 80 trials for each condition (public easy, public difficult, private easy and private difficult), the task will count a total of 320 trials and have a 54 minutes duration, in 3 runs of 17 minutes each. Vicarious Reward experiment: trials will have a 10 seconds maximum duration. Using 40 trials for each condition (other low payoff, other high payoff, self low payoff, self high payoff, control condition), the task will have a total of 200 trials and last for 54 minutes, in 6 runs of 9 minutes each.

Audience effect; Vicarious reward

MEG (MagnetoEncephaloGraphy) OTHER

Both behavioral task (audience effect and vicarious reward) will be studied in MEG (MagnetoEncephaloGraphy). The same paradigms used in the behavioral experiment will be used in MEG. Audience Effect experiment: trials will last for 7 seconds maximum. With 100 trials for each condition (public easy, public difficult, private easy and private difficult), the task will count a total of 400 trials and have a 47 minutes duration. Every 100 trials (about 12 minutes of tasks), a break will be proposed to the participants. Vicarious Reward experiment: trials will have a 7.2 seconds maximum duration. Using 75 trials for each condition (other low payoff, other high payoff, self low payoff, self high payoff, control condition), the task will have a total of 375 trials and last for 45 minutes. Every 125 trials (every 15 minutes), a break will be proposed to the participants.

Audience effect; Vicarious reward

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Aged between 18 and 35
• Right-handed
• French
• Normal vision or corrected by contact lenses

You may not qualify if:

• Contraindications to the MEG examination
• Presence of a perceptual disorder (vision) or motor impairing the capacity to carry out the tasks requested (including dyschromatopsia and achromatopsia).
• Taking of medical treatment in progress (excluding contraceptive pill).
• Known neurological or psychiatric history or disorders.
• Participants who do not benefit from social protection.
• Participants refusing to be informed of the results of the medical examination.
• Participants who refuse to be informed of the possible detection of an anomaly.
• Participants with MRI contraindications

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

CH le Vinatier

Bron, 69677, France

Location

MeSH Terms

Interventions

Magnetoencephalography

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Neurological; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis; Magnetometry; Investigative Techniques

Study Officials

• Caroline DEMILY, MD

  CH le Vinatier

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 7, 2017
• First Posted: April 17, 2017
• Study Start: February 3, 2014
• Primary Completion: July 22, 2016
• Study Completion: July 22, 2016
• Last Updated: November 28, 2017

Record last verified: 2017-11

Locations

FR (1)