NCT03094624|Completed
Auditory Deficits in Congenital Amusia (AMUSIE CONGENITALE)
Auditory Perceptual and Memory Deficits in Congenital Amusia: Studies of Cerebral Correlates With MEG, Anatomical MRI and Functional MRI
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Auditory Perceptual and Memory Deficits in Congenital Amusia: Studies of Cerebral Correlates With MEG, Anatomical MRI and Functional MRI
Sponsor study identifier
interventional
230
1 country
1
Study Start
January 13, 2013
Actual (reported)Primary Completion
May 23, 2019
Actual (reported)Study Completion
May 23, 2019
Actual (reported)The project studies auditory deficits in congenital amusia at the behavioral and neurophysiological levels. The auditory processes investigated are pitch discrimination, short-term memory, sound-induced emotions. To characterize auditory deficits in the amusic population, neuropsychological assessments are combined with neurophysiological markers (Electro-encephalography: EEG, Magneto-encephalography: MEG, Magnetic Resonance Imaging: MRI).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 23, 2019
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 13, 2013
Actual (reported)March 20, 2017
Actual (reported)March 29, 2017
Actual (reported)May 23, 2019
Actual (reported)May 23, 2019
Actual (reported)Correct answers to the neuropsychological tests
Percentages of correct responses
Day 1
Neuropsychological tests reaction times
Neuropsychological tests reaction times
Day 1
Neurophysiological tests EEG
Event-Related Potentials (EEG)
Day 1
Neurophysiological tests MEG
Event-Related Fields (MEG)
Day 1
Neurophysiological tests MRI
Since 2006, recruitment of amusia participants has been organized in the Lyon region, and some 20 participants (and their matched controls in terms of age, sex, laterality, musical practice, number of years of study) have already taken part various studies conducted at the CRNL. The recruitment of amusia participants and controls is continued in order to maintain a sufficient number of participants and compensate for the withdrawals within the cohort already constituted (lack of availability, geographical distance, etc.).
Matched controls of age, sex, laterality, musical practice, number of years of studies.
Neuropsychological tests consist in listening to sounds in various contexts and providing behavioral responses with response-buttons. Neurophysiological tests consist in the recording of EEG and/or MEG signals or MRI images while realizing the neuropsychological tests, as well as anatomical MRI scanning to characterize the participants' brain anatomy and reconstruct the brain sources of surface EEG/MEG signals.
Hospices Civils de Lyon, Hôpital Edouard Herriot
Lyon, 69003, France
Albouy P, Peretz I, Bermudez P, Zatorre RJ, Tillmann B, Caclin A. Specialized neural dynamics for verbal and tonal memory: fMRI evidence in congenital amusia. Hum Brain Mapp. 2019 Feb 15;40(3):855-867. doi: 10.1002/hbm.24416. Epub 2018 Nov 1.
Julien JUNG, MD
Hospices Civils de Lyon
230 participants (actual enrollment reported by the registry).
First Submitted
March 20, 2017
First Posted
March 29, 2017
Study Start
January 13, 2013
Actual (reported)(18)F-FDG PET Database of Adult Healthy Individuals
MRI images
Day 1
Experiment 1 are interested in perception and musical memory vs. Language and contribute to our understanding of the functional and structural organization of the brain to perceive and memorize music and language.
Experiment 2 focuses on perception and musical memory vs. Language and contribute to our understanding of the functional and structural organization of the brain to perceive and memorize music and language. The second experiment will also study short-term memory networks for musical and verbal materials, but the specificity will be the inclusion of a verbal material sung, thus representing the combination of both information. Experiment 2 is divided into two sub-parts. Indeed, the investigators will develop the musical and verbal materials during a first experimental part in experiment (experiment 2a) and then apply them in experimentation MEG (experiment 2b). Experiment 2a will allow us to test new equipment in a short term memory task under conditions that are less restrictive for the participants. Then the investigators will apply the optimal material that emerges for the MEG experiment.
Experiment 3 will use Discordant Negativity (MMN; Mismatch Negativity) protocols in coupled EEG-MEG (experiment 3a) and EEG alone (experiment 3b) to investigate memory traces of sensory information. The MMN is used to probe auditory sensory memory (pre-requisite for short- or long-term storage), and has the advantage of being measured without requiring an active task from the participant.
Experiment 4 will study the neural correlates of long-term memory for musical and verbal material with fMRI. The testimonies of the amusicians suggest a deficit of the "musical lexicon" which contrasts with that the musical lexicon elaborated of the non-musician listeners.
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Primary Completion
May 23, 2019
Actual (reported)Study Completion
May 23, 2019
Actual (reported)Last Updated
September 10, 2025
Record last verified: 2025-09
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Source: ClinicalTrials.gov.
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