NCT03074253|Unknown
Cardiovascular Imaging and Biomarker Analyses (CIBER)
CIBER
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CIBER
Sponsor study identifier
observational
500
1 country
1
Study Start
December 1, 2014
Actual (reported)Primary Completion
July 1, 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
July 1, 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
"Cardiovascular Imaging and Biomarker Analyses (CIBER)" is a single-center, prospective and observational study evaluating the expression of novel biomarkers in patients undergoing cardiacvascular imaging within clinical routine care. It is aimed to evaluate associations with biomarker expressions with ascertained cardiac imaging parameters.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 1, 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 1, 2014
Actual (reported)March 3, 2017
Actual (reported)March 8, 2017
Actual (reported)July 1, 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
July 1, 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Biomarker levels before cardiac imaging
24 hours before cardiac imaging
Patients are undergoing echocardiography
Patients are undergoing magnetic resonance imaging
Patients undergoing cardiac imaging (i.g. echocardiography, cardiac MRI, cardiac CT) within the clinical routine.
First Department of Medicine, University Medical Centre Mannheim
Mannheim, 68167, Germany
Kim SH, Behnes M, Natale M, Hoffmann J, Reckord N, Hoffmann U, Budjan J, Henzler T, Papavassiliu T, Borggrefe M, Bertsch T, Akin I. Galectin-3 Reflects Mitral Annular Plane Systolic Excursion Being Assessed by Cardiovascular Magnetic Resonance Imaging. Dis Markers. 2016;2016:7402784. doi: 10.1155/2016/7402784. Epub 2016 Dec 1.
Behnes M, Lang S, Breithardt OA, Kaden JJ, Haghi D, Ahmad-Nejad P, Elmas E, Wolpert C, Borggrefe M, Neumaier M, Brueckmann M. Association of NT-proBNP with severity of heart valve disease in a medical patient population presenting with acute dyspnea or peripheral edema. J Heart Valve Dis. 2008 Sep;17(5):557-65.
One peripheral blood withdraws in EDTA, citrate, ammonium heparin, serum tubes within 24 hours before cardiac imaging.
Ibrahim Akin, Prof. Dr.
University Medical Center Mannheim
First Submitted
March 3, 2017
First Posted
March 8, 2017
Study Start
December 1, 2014
Actual (reported)Primary Completion
July 1, 2020
Estimated (date passed)Get Going: Accelerometer-Based Intervention to Promote Physical Activity in Frail Older Adults
Patients are undergoing computed tomography
Peripheral blood samples are being collected from all patients
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Behnes M, Bertsch T, Weiss C, Ahmad-Nejad P, Akin I, Fastner C, El-Battrawy I, Lang S, Neumaier M, Borggrefe M, Hoffmann U. Triple head-to-head comparison of fibrotic biomarkers galectin-3, osteopontin and gremlin-1 for long-term prognosis in suspected and proven acute heart failure patients. Int J Cardiol. 2016 Jan 15;203:398-406. doi: 10.1016/j.ijcard.2015.10.127. Epub 2015 Oct 20.
Behnes M, Brueckmann M, Lang S, Espeter F, Weiss C, Neumaier M, Ahmad-Nejad P, Borggrefe M, Hoffmann U. Diagnostic and prognostic value of osteopontin in patients with acute congestive heart failure. Eur J Heart Fail. 2013 Dec;15(12):1390-400. doi: 10.1093/eurjhf/hft112. Epub 2013 Jul 12.
Ansari U, Behnes M, Hoffmann J, Weidner K, Kuche P, Rusnak J, Kim SH, Natale M, Reckord N, Lang S, Hoffmann U, Bertsch T, Fatar M, Borggrefe M, Akin I. Galectin-3 reflects the echocardiographic quantification of right ventricular failure. Scand Cardiovasc J. 2021 Dec;55(6):362-370. doi: 10.1080/14017431.2021.1995036. Epub 2021 Nov 5.
Hoffmann J, Behnes M, Ansari U, Weidner K, Kuche P, Rusnak J, Kim SH, Natale M, Reckord N, Lang S, Hoffmann U, Bertsch T, Fatar M, Borggrefe M, Akin I. The association of high-sensitivity cardiac troponin I and T with echocardiographic stages of heart failure with preserved ejection fraction. Ann Clin Biochem. 2019 Jul;56(4):431-441. doi: 10.1177/0004563219841644. Epub 2019 May 21. No abstract available.
Rusnak J, Behnes M, Henzler T, Reckord N, Vogler N, Meyer M, Hoffmann U, Natale M, Hoffmann J, Hamed S, Weidner K, Lang S, Mukherji A, Haubenreisser H, Schoenberg SO, Borggrefe M, Bertsch T, Akin I. Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score. Eur J Med Res. 2017 Nov 16;22(1):47. doi: 10.1186/s40001-017-0290-9.
Rusnak J, Behnes M, Reckord N, Hoffmann U, Natale M, Hoffmann J, Weidner K, Lang S, Mukherji A, Kruska M, Henzler T, Schoenberg SO, Borggrefe M, Bertsch T, Akin I. High Sensitivity Troponins Discriminate Different Morphologies of Coronary Artery Plaques Being Assessed by Coronary Computed Tomography Angiography. Dis Markers. 2017;2017:9306409. doi: 10.1155/2017/9306409. Epub 2017 Jul 18.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
July 1, 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
October 31, 2019
Record last verified: 2019-10
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Source: ClinicalTrials.gov.
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