NCT02483663|Completed
Brain Regulation of Appetite in Twins
BRAT
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BRAT
Sponsor study identifier
observational
122
1 country
1
Study Start
August 2010
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
August 2015
Actual (reported)Study Completion
August 2015
Actual (reported)Scientists are examining the genetic and environmental influences on appetite and weight gain. The main purpose of this study is to look at how genetic and environmental factors may influence how the brain regulates appetite and food intake. Understanding how the brain regulates appetite and food intake may eventually lead to new ways to help people avoid obesity or lose weight.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 2015
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 2010
Date type not reportedThis date has not been verified as actual or estimated.
June 17, 2015
Actual (reported)June 29, 2015
Actual (reported)August 2015
Actual (reported)August 2015
Actual (reported)Meal-induced nutrient and hormonal changes in plasma (insulin, GLP-1, ghrelin, glucose)
Baseline
Brain activation during fMRI in satiety-related regions
Baseline
Body composition: fasting leptin and dual energy X-ray absorptiometry (DXA)
Baseline
DNA evaluation of FTO genotypes
Baseline
Objective satiety: caloric and macronutrient intake
Baseline
Subjective satiety: visual analog scale (VAS) scores and appeal ratings
Baseline
Measure brain activity.
Body composition measurements.
Monozygotic and dizygotic twins recruited from the University of Washington Twin Registry
University of Washington
Seattle, Washington, 98195, United States
Melhorn SJ, Askren MK, Chung WK, Kratz M, Bosch TA, Tyagi V, Webb MF, De Leon MRB, Grabowski TJ, Leibel RL, Schur EA. FTO genotype impacts food intake and corticolimbic activation. Am J Clin Nutr. 2018 Feb 1;107(2):145-154. doi: 10.1093/ajcn/nqx029.
Mestre ZL, Melhorn SJ, Askren MK, Tyagi V, Gatenby C, Young L, Mehta S, Webb MF, Grabowski TJ, Schur EA. Effects of Anxiety on Caloric Intake and Satiety-Related Brain Activation in Women and Men. Psychosom Med. 2016 May;78(4):454-64. doi: 10.1097/PSY.0000000000000299.
Ellen Schur, MD, MS
University of Washington
122 participants (actual enrollment reported by the registry).
First Submitted
June 17, 2015
First Posted
June 29, 2015
Study Start
August 2010
Date type not reportedThis date has not been verified as actual or estimated.
Neural Response to Eating and Weight Status
Questionnaires related to: health, weight, sleep, mood, dietary habits, attitudes towards eating, how you describe yourself.
Answer questions about how you are feeling at the moment.
Breakfast, a snack, and lunch provided during study visit.
Perform a series of computer tests to determine reaction time.
Blood samples collected throughout regular intervals during the study visit day to measure levels of hormones involved in regulating appetite and body weight. We will also determine if twins are fraternal or identical and will examine DNA to see if participants carry two genes that affect appetite or body weight, the FTO gene and the MC4R gene.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Melhorn SJ, Mehta S, Kratz M, Tyagi V, Webb MF, Noonan CJ, Buchwald DS, Goldberg J, Maravilla KR, Grabowski TJ, Schur EA. Brain regulation of appetite in twins. Am J Clin Nutr. 2016 Feb;103(2):314-22. doi: 10.3945/ajcn.115.121095. Epub 2016 Jan 6.
Primary Completion
August 2015
Actual (reported)Study Completion
August 2015
Actual (reported)Last Updated
October 27, 2017
Record last verified: 2017-10
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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