Brain Regulation of Appetite in Twins
BRAT
1 other identifier
observational
122
1 country
1
Brief Summary
Scientists are examining the genetic and environmental influences on appetite and weight gain. The main purpose of this study is to look at how genetic and environmental factors may influence how the brain regulates appetite and food intake. Understanding how the brain regulates appetite and food intake may eventually lead to new ways to help people avoid obesity or lose weight.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Aug 2010
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2010
CompletedFirst Submitted
Initial submission to the registry
June 17, 2015
CompletedFirst Posted
Study publicly available on registry
June 29, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2015
CompletedOctober 27, 2017
October 1, 2017
5 years
June 17, 2015
October 25, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (6)
Meal-induced nutrient and hormonal changes in plasma (insulin, GLP-1, ghrelin, glucose)
Baseline
Brain activation during fMRI in satiety-related regions
Baseline
Body composition: fasting leptin and dual energy X-ray absorptiometry (DXA)
Baseline
DNA evaluation of FTO genotypes
Baseline
Objective satiety: caloric and macronutrient intake
Baseline
Subjective satiety: visual analog scale (VAS) scores and appeal ratings
Baseline
Study Arms (2)
27 Monozygotic Pairs
27 Dizygotic Pairs
Interventions
Measure brain activity.
Body composition measurements.
Questionnaires related to: health, weight, sleep, mood, dietary habits, attitudes towards eating, how you describe yourself.
Answer questions about how you are feeling at the moment.
Breakfast, a snack, and lunch provided during study visit.
Perform a series of computer tests to determine reaction time.
Blood samples collected throughout regular intervals during the study visit day to measure levels of hormones involved in regulating appetite and body weight. We will also determine if twins are fraternal or identical and will examine DNA to see if participants carry two genes that affect appetite or body weight, the FTO gene and the MC4R gene.
Eligibility Criteria
Monozygotic and dizygotic twins recruited from the University of Washington Twin Registry
You may qualify if:
- Ability and willingness to come with their twin to the University of Washington (Seattle)
- Additional Criteria for Aim 1 random sample only: Member of randomly selected MZ pair or
- Additional criteria for Aim 2 random sample only: One member of MZ or same-sex DZ pair with BMI of at least 30 kg/m\^2
- Additional criteria for Aim 3 sample only: Member of randomly selected MZ pair, and not BMI discordant ≥ 5 kg/m\^2
You may not qualify if:
- History of weight loss surgery or active participation in weight loss program
- Major medical problem (e.g., diabetes, cancer)
- Current use of weight loss medications or other medications known to alter appetite
- Pregnancy or menopause
- MRI contraindication (i.e., implanted metal, claustrophobia)
- Lifetime eating disorder
- Current smoking
- Current heavy alcohol use (≥2 drinks per day for females and ≥ 3 drinks per day for males)
- Self-reported weight \>330 pounds at time of phone screening. MRI cannot accommodate all shapes or weights. Inability to have MRI does not exclude subject from participating in other study procedures.
- BMI \< 18.5 or \> 45 kg/m\^2
- Allergies to study foods or inability to taste
- Twins were raised apart
- Co-twin not eligible or not willing to participate
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Washingtonlead
- Fred Hutchinson Cancer Centercollaborator
- Columbia Universitycollaborator
Study Sites (1)
University of Washington
Seattle, Washington, 98195, United States
Related Publications (3)
Melhorn SJ, Askren MK, Chung WK, Kratz M, Bosch TA, Tyagi V, Webb MF, De Leon MRB, Grabowski TJ, Leibel RL, Schur EA. FTO genotype impacts food intake and corticolimbic activation. Am J Clin Nutr. 2018 Feb 1;107(2):145-154. doi: 10.1093/ajcn/nqx029.
PMID: 29529147DERIVEDMestre ZL, Melhorn SJ, Askren MK, Tyagi V, Gatenby C, Young L, Mehta S, Webb MF, Grabowski TJ, Schur EA. Effects of Anxiety on Caloric Intake and Satiety-Related Brain Activation in Women and Men. Psychosom Med. 2016 May;78(4):454-64. doi: 10.1097/PSY.0000000000000299.
PMID: 26867073DERIVEDMelhorn SJ, Mehta S, Kratz M, Tyagi V, Webb MF, Noonan CJ, Buchwald DS, Goldberg J, Maravilla KR, Grabowski TJ, Schur EA. Brain regulation of appetite in twins. Am J Clin Nutr. 2016 Feb;103(2):314-22. doi: 10.3945/ajcn.115.121095. Epub 2016 Jan 6.
PMID: 26739033DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ellen Schur, MD, MS
University of Washington
Study Design
- Study Type
- observational
- Observational Model
- FAMILY BASED
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor, Medicine
Study Record Dates
First Submitted
June 17, 2015
First Posted
June 29, 2015
Study Start
August 1, 2010
Primary Completion
August 1, 2015
Study Completion
August 1, 2015
Last Updated
October 27, 2017
Record last verified: 2017-10