Effect of Medium Chain Triglyceride Consumption on Appetite
MCT
1 other identifier
interventional
17
1 country
1
Brief Summary
The purpose of this study is to test the effects of medium chain triglyceride consumption, relative to long chain triglycerides, on hormones involved in appetite regulation and food intake in overweight men. We expect medium chain triglycerides to reduce appetite and food intake and to do so by increasing levels of hormones known to be involved in satiety and reduce levels of those involved in appetite.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable obesity
Started Jun 2010
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2011
CompletedFirst Submitted
Initial submission to the registry
September 25, 2013
CompletedFirst Posted
Study publicly available on registry
September 30, 2013
CompletedSeptember 30, 2013
September 1, 2013
1.2 years
September 25, 2013
September 27, 2013
Conditions
Outcome Measures
Primary Outcomes (1)
Food intake
Intake at an ad libitum meal 3 h after test oil consumption (Study 1) or 1 h after a pre-load containing the test oil (Study 2)
up to 3 hours
Secondary Outcomes (6)
Ghrelin
3 hours
Peptide YY
3 hours
Glucagon-like peptide 1
3 hours
Insulin
3 hours
Triglycerides
3 hours
- +1 more secondary outcomes
Study Arms (2)
MCT
ACTIVE COMPARATORMCT oil (20 g) was included in the test breakfast
LCT
PLACEBO COMPARATORCorn oil (20 g) was included in the test breakfast
Interventions
Eligibility Criteria
You may qualify if:
- Males
- Weight stable (\<10 lb over previous 3 months)
- Overweight (body mass index 25-29.9)
You may not qualify if:
- Smokers
- Excessive caffeine users
- Severe health conditions
- Allergy to food products/ingredients in the study
- Taking medications known to affect energy expenditure or gastrointestinal function
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
New York Obesity Nutrition Research Center
New York, New York, 10025, United States
Related Publications (1)
St-Onge MP, Mayrsohn B, O'Keeffe M, Kissileff HR, Choudhury AR, Laferrere B. Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men. Eur J Clin Nutr. 2014 Oct;68(10):1134-40. doi: 10.1038/ejcn.2014.145. Epub 2014 Jul 30.
PMID: 25074387DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Marie-Pierre St-Onge, Ph.D
New York Obesity Nutrition Research Center
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Research Associate
Study Record Dates
First Submitted
September 25, 2013
First Posted
September 30, 2013
Study Start
June 1, 2010
Primary Completion
August 1, 2011
Study Completion
August 1, 2011
Last Updated
September 30, 2013
Record last verified: 2013-09