Protocol of Virtual Interactive Memory-Training Program

NCT02462135 | Completed DMC

• 1 other identifier: 201301045
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study sought to investigate the changes in objective memory performance (including immediate recall and delayed recall), subjective memory complaints and degree of depression in older adults with mild cognitive impairment after Virtual interactive memory training (VIMT).

Conditions

Mild Cognitive Impairment

Keywords

Mild cognitive impairment; Memory training; Randomized controlled study

Outcome Measures

Primary Outcomes (1)

• Change in objective memory performance as measured by the Chinese version of the Wechsler Memory Scale-III (WMS-III).

  Change from baseline in objective memory performance at Immediate post-test, 3 months, 6 months and one year after intervention.

Secondary Outcomes (1)

• Change in subjective memory complaints as measured by the Multifactorial Memory Questionnaire (MMQ).

  Change from baseline in subjective memory complaints at Immediate post-test, 3 months, 6 months and one year after intervention.

Study Arms (2)

Virtual interactive memory training

EXPERIMENTAL

Training sessions of the VIMT group are divided into initial training and booster training. Each training session is 45 minutes/day, 3 sessions/week, for 12 weeks for both initial training and booster training (36 sessions each).

Behavioral: Virtual interactive memory training

Passive information activities

ACTIVE COMPARATOR

The training of active control group is the same as VIMT group (45 min/day, 3 days/week, for 12 weeks, for a total of 36 sessions). The active control group receives only the initial training.

Behavioral: Passive information activities

Interventions

Virtual interactive memory training BEHAVIORAL

Training sessions of the VIMT group are divided into initial training and booster training. Each training session is 45 minutes/day, 3 sessions/week, for 12 weeks for both initial training and booster training (36 sessions each). The training content of the four memory training include: (1) spatial encoding memory training task, (2) updating-spatial memory training task, (3) updating-visual memory training task, and (4) rehearsal-visuospatial memory training task.

Also known as: Memory training

Virtual interactive memory training

Passive information activities BEHAVIORAL

The active control group (Passive information activities) only accepts the initial training phase, which training content of the two types to include: (1) listening to audio books, and (2) reading online newspaper.

Also known as: Active control group

Passive information activities

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Participants must endorse at least two items from a list of frequent subjective memory complaints by patient and/or an informant
• Objective memory impairment on neuropsychological tests of memory 1.5 SD or more below age/education norms
• Clinical neurologic examination by the Mini-Mental State Examination (MMSE) score of 24 or higher, and cut-off score of 23/24 on the Montreal Cognitive Assessment (MoCA)
• No impairment in personal activities of daily living (P-ADL) as determined by clinical interview with participant and family

You may not qualify if:

• The clinical diagnosis of dementia was based on the DSM-IV-TR
• Active in another cognitive or memory-related training in the past year
• Comorbid medical conditions that would predispose them to imminent functional decline or cognitive impairment
• A diagnosis of major neurological or psychiatric illness history and/or behavioral problems that would sufficiently impair performance to make participation impossible
• Severe losses in vision, hearing, or communicative ability

Sponsors & Collaborators

• Ministry of Science and Technology, Taiwan: lead

Study Sites (1)

Residential care facilities

Taipei, 22176, Taiwan

Location

Related Publications (1)

• Yang HL, Chu H, Kao CC, Chiu HL, Tseng IJ, Tseng P, Chou KR. Development and effectiveness of virtual interactive working memory training for older people with mild cognitive impairment: a single-blind randomised controlled trial. Age Ageing. 2019 Jul 1;48(4):519-525. doi: 10.1093/ageing/afz029.

  PMID: 30989165 DERIVED

MeSH Terms

Conditions

Cognitive Dysfunction

Interventions

Cognitive Training

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Neurological Rehabilitation; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Study Officials

• Hui-Ling Yang, PhD

  Taipei Medical University

  PRINCIPAL INVESTIGATOR

• Kuei-Ru Chou, Professor

  Taipei Medical University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Ph.D. candidate

Study Record Dates

• First Submitted: May 28, 2015
• First Posted: June 3, 2015
• Study Start: March 1, 2014
• Primary Completion: December 1, 2017
• Study Completion: December 1, 2017
• Last Updated: December 15, 2017

Record last verified: 2017-12

Locations

TW (1)