Behavior During Experimentally Induced Pain

NCT01594528 | Completed Results

• 1 other identifier: 2012-A00048-35
• Study Type: interventional
• Target: 49
• Locations: 1 country
• Sites: 1

Brief Summary

Numerous factors can influence the processing of pain message: the affective or emotional, the sensorial and the cognitive components. Interindividual variations at the emotional and cognitive levels may interfere with the pain message and the consecutive behavior. Some modifications in these components are observed in psychiatric troubles, but their influences on the behavior to pain have not been studied, although they have been studied in some populations characterized as non communicating, with obvious cognitive degradations (subject with dementia, older, newborns,…).In an other study in course, the past pain experience is explored in relation to results to experimental pain tests, emotional and anxious characteristics. This present pilot study aims at studying the infra-verbal behavioural signs during experimentally induced pain in subjects with schizophrenia, major depression, and controls.

Conditions

Schizophrenia; Major Depression

Keywords

schizophrenia; major depression; pain; behavior

Outcome Measures

Primary Outcomes (1)

• Indicators / Minute

  number of corporal mobility, facial expression and sound indicators

  during pain tests (average 1 hour)

Study Arms (3)

SC

EXPERIMENTAL

behavior as defined with facial, corporal and vocal indicators during experimental pain tests for subjects with schizophrenia

Other: pain tests

controls

EXPERIMENTAL

behavior as defined with facial, corporal and vocal indicators during experimental pain tests for subjects without any psychiatric trouble

Other: pain tests

MD

EXPERIMENTAL

behavior as defined with facial, corporal and vocal indicators during experimental pain tests for subjects with major depression

Other: pain tests

Interventions

pain tests OTHER

pain induction with pressure application or ischemia on the arm

MD; SC; controls

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• subjects with psychiatric trouble : diagnosis of schizophrenia or major depression according to the DSM-IV-TR criteria.
• control subjects : without known psychiatric history.
• age between 18 and 60.

You may not qualify if:

• absence of consent, hospitalization under constraint, absence of health insurance.
• inability to answer the questionnaires
• pregnancy
• antalgic or analgesic treatment
• allergy to latex
• non stabilized high blood pressure, bad blood coagulation,
• peripheral neuropathy, nerve lesion, dermatosis at the superior extremities, muscular lesion or pathology at the upper member level
• non treated alcohol dependence
• illegal substance consumption in the past 48 hours

Sponsors & Collaborators

• Centre Hospitalier Esquirol: lead

Study Sites (1)

Centre Hospitalier Esquirol

Limoges, 87025, France

Location

MeSH Terms

Conditions

Schizophrenia; Depressive Disorder, Major; Pain; Behavior

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Depressive Disorder; Mood Disorders; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: Dr Murielle Girard
• Organization: Centre Hospitalier Esquirol

murielle.girard@ch-esquirol-limoges.fr

0033555431028

Study Officials

• Dominique Malauzat, MD

  Centre Hospitalier Esquirol

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, Head of Research Department

Study Record Dates

• First Submitted: March 13, 2012
• First Posted: May 9, 2012
• Study Start: April 1, 2012
• Primary Completion: December 1, 2013
• Study Completion: December 1, 2013
• Last Updated: March 22, 2019
• Results First Posted: March 22, 2019

Record last verified: 2018-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)