Can we Forget? Directed Forgetting and Embodied Cognition in Schizophrenia

NCT02538445 | Completed

• 2 other identifiers: 10011562010-A01372-37
• Study Type: interventional
• Target: 96
• Locations: 1 country
• Sites: 1

Brief Summary

Based on the theory of embodied cognition, which focuses on the influence of sensory and motor processes on cognition, researchers propose to study the influence of the action on memorization and inhibition in patients suffering from schizophrenia, using a directed forgetting paradigm. The directed forgetting paradigm is used, composed of two lists of action verbs. The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug. Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)). A recognition task is performed at the end. The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only. 48 schizophrenic patients were included in this study. Patients were randomized to have 10 participants per condition. 48 controls matched by age, gender, laterality and education are also included and randomized in the same modality. This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.

Conditions

Schizophrenia

Keywords

Schizophrenia; Memory; Cognition

Outcome Measures

Primary Outcomes (1)

• Number of items recalled TBR and TBF

  It is asked to the participants to recall orally, only TBR verbs (task of reminder). The experimenter notes the given verbs.

  Day 1

Secondary Outcomes (2)

• Number of recognized items

  Day 1

• Reaction time (ms) on the recognition of TBR and TBF

  Day 1

Study Arms (8)

Patients group 1

EXPERIMENTAL

Memorization of the verbs by miming the action

Other: Memorization of the verbs by miming the action

Patients group 2

EXPERIMENTAL

Memorization of the verbs by imagining the action

Other: Memorization of the verbs by imagining the action

Patients group 3

EXPERIMENTAL

Memorization of the action verbs by means of another word

Other: Memorization of the action verbs by means of another word

Patients group 4

EXPERIMENTAL

Simple memorization of the verbs

Other: Simple memorization of the verbs

Healthy volonteers group 1

ACTIVE COMPARATOR

Memorization of the verbs by miming the action

Other: Memorization of the verbs by miming the action

Healthy volonteers group 2

ACTIVE COMPARATOR

Memorization of the verbs by imagining the action

Other: Memorization of the verbs by imagining the action

Healthy volonteers group 3

ACTIVE COMPARATOR

Memorization of the action verbs by means of another word

Other: Memorization of the action verbs by means of another word

Healthy volonteers group 4

ACTIVE COMPARATOR

Simple memorization of the verbs

Other: Simple memorization of the verbs

Interventions

Memorization of the verbs by miming the action OTHER

The participant reads aloud the verbs that appear on the screen, by performing the corresponding action verb.

Healthy volonteers group 1; Patients group 1

Memorization of the verbs by imagining the action OTHER

The participant reads aloud the verbs that appear on the screen, by imagining the corresponding action verb.

Healthy volonteers group 2; Patients group 2

Memorization of the action verbs by means of another word OTHER

The participant reads aloud the verbs that appear on the screen. Then, he reads, without memorizing it, a word associated with the action verb to be learnt to favor the memorization of that one. The word is written near the action verb.

Healthy volonteers group 3; Patients group 3

Simple memorization of the verbs OTHER

The participant reads aloud the verbs that appear on the screen, without additional instructions (control condition).

Healthy volonteers group 4; Patients group 4

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Schizophrenic patients as defined in Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV)
• Stabilized a therapeutic point of view for at least one month.
• Consent form signed
• Affiliated to a Security Health Program
• Consent form signed
• Affiliated to a Security Health Program

You may not qualify if:

• Not having a history of head trauma, neurological disease or not stabilized serious somatic illness,
• Not to use psychoactive substance, as defined by the DSM IV.
• The Intelligence Quotient must not be less than 70 (Progressive Matrices Standard score (PM38), Raven Progressive Matrix).

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Saint Etienne: lead

Study Sites (1)

CHU de SAINT-ETIENNE

Saint-Etienne, 42000, France

Location

MeSH Terms

Conditions

Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Officials

• Anne GROSSELIN, MD

  CHU de Saint-Etienne

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 31, 2015
• First Posted: September 2, 2015
• Study Start: May 1, 2011
• Primary Completion: December 1, 2012
• Study Completion: December 1, 2012
• Last Updated: March 23, 2016

Record last verified: 2015-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)