Motivation and Executive Control in Schizophrenia

NCT02734927 | Completed DMC

• 1 other identifier: 2012-A00026-37
• Study Type: interventional
• Target: 41
• Locations: 1 country
• Sites: 1

Brief Summary

In order to control a behaviour, investigators need to realise goal directed actions and to priories some actions. This control is required in unusual situation. Appropriate actions are selected and coordinated according to context and aim. Several studies try to draw a model of executive function. Recently, Koechlin has suggested a three levelled organisation to explain how the prefrontal cortex controls actions. Contextual control is useful to answer appropriately with the immediate context. Episodic control allows selecting the action according to specific information given before. Sensorial control is the automatic response when a stimulus is presented. Some diseases like schizophrenia are associated with neurological dysfunction in prefrontal cortex. Chambon and al (2008) have identified a dysfunction of contextual control in schizophrenia. As the prefrontal cortex is involved in motivational process, it seems interesting to study potential links between executive function and motivation. A study from Kouneiher shows contextual and episodic activation of motivation in healthy population. Investigators aim to study the way motivational process are recruited in schizophrenia.

Conditions

Schizophrenia

Keywords

schizophrenia; motivation; executive control

Outcome Measures

Primary Outcomes (1)

• reaction time

  reaction time is recorded when the subject press the key (subject should press a key function of the characteristics of the letter submitted)Reaction time should vary with the level of executive control (episodic, contextual, and motivation control (episodic or contextual motivation). Responses will be compared across patients and control.

  24 hours

Study Arms (2)

schizophrenia group

ACTIVE COMPARATOR

Schizophrenia patients suffering

Other: realization of computerized exercises

control group

SHAM COMPARATOR

subjects showing no psychological or neurological disorder

Other: realization of computerized exercises

Interventions

realization of computerized exercises OTHER

control group; schizophrenia group

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18-45 years old
• schizophrenia
• french native speaker

You may not qualify if:

• Neurological disease
• Motor or visual deficit
• Somatic treatment with neurological impact
• Drug abuse

Sponsors & Collaborators

• Hôpital le Vinatier: lead

Study Sites (1)

Professeur FRANCK Nicolas

Bron, Auvergne-Rhône-Alpes, 69678, France

Location

MeSH Terms

Conditions

Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 7, 2016
• First Posted: April 12, 2016
• Study Start: November 1, 2012
• Primary Completion: April 24, 2018
• Study Completion: April 24, 2018
• Last Updated: April 26, 2018

Record last verified: 2018-04

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)