Past Pain Experience and Perception of Experimental Pain

NCT01575912 | Completed Results

• 1 other identifier: 2012-A00047-36
• Study Type: observational
• Target: 92
• Locations: 1 country
• Sites: 1

Brief Summary

Differences in pain perception between subjects with and without psychiatric illness may be influenced by the individual experience, and not primarily by the pathology, although the pathological frame may amplify it.The aim of this study is to establish if the characteristics of experimental pain feeling are influenced by the past pain experience, anxiety and emotion, independently from the diagnosis. The pain experience will be evaluated by an inventory of the potentially painful situations that one can come across through the life, to determine the following points : Number of painful events in the past, number of painful points during the last 6 months, number of painful events lasting more than 6 months, sum of pain intensities (graduated with Visual Analogic Scale VAS from 0 to 10), sum of gravity (evaluated from 0 to 5), the category of pain experience qualification (mostly affective, mostly sensorial, or both). Schizophrenic, depressed and control participants will be recruited, and their pain experience throughout life will be put it in relation to experimental pain tests results (pressure application, ischemia induction), anxiety and emotion (Hospital Anxiety and Depression scale HAD), catastrophizing (Pain Catastrophizing Scale PCS), Heart Rate (HR) variation, Blood Pressure (BP) variation.

Conditions

Schizophrenia; Major Depression

Keywords

Schizophrenia; Major depression; Pain; Past pain experience

Outcome Measures

Primary Outcomes (1)

• Visual Analog Scale Evaluation for the Pre-fixed Pressure Test

  pain tests will be realized during the first week of hospitalization for the persons hospitalized for major depression, and during the period of hospitalization (after stabilization) for the persons presenting schizophrenia. The controls are tested within one month of the study information. total range : 0 - 10. The intensity of pain increases with the value of VAS. 10 corresponds to an unbearable pain.

  one month

Study Arms (3)

schizophrenia SC

subjects with a diagnosis of schizophrenia (SC) according to the DSM-IV-TR, submitted to experimental pain tests

Other: experimental pain tests

major depression MD

subjects with a diagnosis of major depression (MD) according to the DSM-IV-TR, submitted to experimental pain tests

Other: experimental pain tests

controls C

subjects without any diagnosis of psychiatric disorder (C) submitted to experimental pain tests

Other: experimental pain tests

Interventions

experimental pain tests OTHER

controls C; major depression MD; schizophrenia SC

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Subjects hospitalized in the Esquirol Hospital center with schizophrenia or major depression according to the DSM-IV-TR criteria. Subjects without without known psychiatric history. Recruited persons will be matched according to age classes.

You may qualify if:

• subjects with psychiatric trouble : diagnosis of schizophrenia or major depression according to the DSM-IV-TR criteria.
• control subjects : without known psychiatric history.
• age between 18 and 60.

You may not qualify if:

• absence of consent, hospitalization under constraint, absence of health insurance.
• inability to answer the questionnaires
• pregnancy
• antalgic or analgesic treatment
• allergy to latex
• non stabilized high blood pressure, bad blood coagulation,
• peripheral neuropathy, nerve lesion, dermatosis at the superior extremities, muscular lesion or pathology at the upper member level
• non treated alcohol dependence
• illegal substance consumption in the past 48 hours

Sponsors & Collaborators

• Centre Hospitalier Esquirol: lead

Study Sites (1)

Centre Hospitalier Esquirol

Limoges, 87025, France

Location

Related Publications (1)

• Girard M, Plansont B, Bonnabau H, Malauzat D. Experimental pain hypersensitivity in schizophrenic patients. Clin J Pain. 2011 Nov-Dec;27(9):790-5. doi: 10.1097/AJP.0b013e31821d904c.

  PMID: 21593663 BACKGROUND

MeSH Terms

Conditions

Schizophrenia; Depressive Disorder, Major; Pain

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Depressive Disorder; Mood Disorders; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: Dr Murielle Girard
• Organization: Centre Hospitalier Esquirol

murielle.girard@ch-esquirol-limoges.fr

0033555431028

Study Officials

• Dominique Malauzat, MD

  Centre Hospitalier Esquirol

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: March 13, 2012
• First Posted: April 12, 2012
• Study Start: March 1, 2012
• Primary Completion: January 1, 2014
• Study Completion: January 1, 2014
• Last Updated: June 12, 2017
• Results First Posted: May 3, 2017

Record last verified: 2017-06

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)