Molecular Screening for Lynch Syndrome in Southern Denmark
2 other identifiers
observational
2,000
1 country
7
Brief Summary
A clinically applicably strategy for molecular screening for Lynch Syndrome has been implemented in the Region of Southern Denmark. Based on sequential analysis with immunohistochemistry and methylation analysis, patients with possible hereditary colorectal cancer are identified. These patients are offered genetic risk assessment and counselling. The study hypothesis is that molecular screening will identify more patients with Lynch Syndrome than the family history alone. Prospective data collection is performed using established clinical databases.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2010
Longer than P75 for all trials
7 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2010
CompletedFirst Submitted
Initial submission to the registry
October 6, 2010
CompletedFirst Posted
Study publicly available on registry
October 7, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2015
CompletedSeptember 14, 2015
September 1, 2015
2 years
October 6, 2010
September 11, 2015
Conditions
Study Arms (1)
All colorectal cancer patients
Interventions
Eligibility Criteria
All colorectal cancer patients in the geographical region of southern Denmark
You may qualify if:
- Histological diagnosis of colorectal adenocarcinoma
- Diagnosed at one of the five departments of pathology in the region
You may not qualify if:
- None
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Vejle Hospitallead
Study Sites (7)
Department of Pathology
Esbjerg, Denmark
Department of Clinical Genetics
Odense, Denmark
Department of Pathology
Odense, Denmark
Department of Pahology
Svendborg, Denmark
Department of Pathology
Sønderborg, Denmark
Department of Clinical Genetics
Vejle, Denmark
Department of Pathology
Vejle, Denmark
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 6, 2010
First Posted
October 7, 2010
Study Start
October 1, 2010
Primary Completion
October 1, 2012
Study Completion
September 1, 2015
Last Updated
September 14, 2015
Record last verified: 2015-09