NCT01310920

Brief Summary

Evidence has been documented for the close relationship between the arrhythmia pathogenesis and the gene expression in renin-angiotensin system. However, it remains unclear for involvement of RAS in the pathogenesis of non-familial sick sinus syndrome. The researchers thus investigated the possible relationship between non-familial sick sinus syndrome and the polymorphism and haplotype of the AGT promoter.

Trial Health

55
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
400

participants targeted

Target at P75+ for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2011

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

March 6, 2011

Completed
3 days until next milestone

First Posted

Study publicly available on registry

March 9, 2011

Completed
Last Updated

March 9, 2011

Status Verified

March 1, 2011

First QC Date

March 6, 2011

Last Update Submit

March 8, 2011

Conditions

Sick Sinus Syndrome

Study Arms (2)

sick sinus syndrome

Other: observation

control

Interventions

observationOTHER

genotyping

sick sinus syndrome

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

The case group includes 200 patients and the control group includes 200 patients.

You may qualify if:

  • sick sinus syndrome

You may not qualify if:

  • Severe systemic disease.
  • Acute coronary syndrome.
  • bradycardia with reversible cause.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

China Medical University Hospital

Dawan, Taiwan, 404, Taiwan

RECRUITING

Related Publications (1)

  • Mangrum JM, DiMarco JP. The evaluation and management of bradycardia. N Engl J Med. 2000 Mar 9;342(10):703-9. doi: 10.1056/NEJM200003093421006. No abstract available.

    PMID: 10706901BACKGROUND

MeSH Terms

Conditions

Sick Sinus Syndrome

Interventions

Observation

Condition Hierarchy (Ancestors)

Arrhythmia, SinusArrhythmias, CardiacHeart DiseasesCardiovascular DiseasesHeart BlockCardiac Conduction System DiseasePathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

MethodsInvestigative Techniques

Study Officials

  • Jan-Yow Chen, M.D.

    China Medical University Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Jan-Yow Chen, MD

CONTACT

+886-4-22062121janyow@ms77.hinet.net

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Sponsor Type
OTHER

Study Record Dates

First Submitted

March 6, 2011

First Posted

March 9, 2011

Study Start

February 1, 2011

Last Updated

March 9, 2011

Record last verified: 2011-03

Locations

TW(1)