Biomedical Research Informatics Centre for Cardiovascular Sciences (The BRICCS Study)
1 other identifier
observational
9,500
1 country
1
Brief Summary
This project will examine the diagnosis and prognosis of patients with cardiovascular disease in hospital in- and outpatients and compare their characteristics with normal controls from the community. The cardiovascular diseases studied include coronary artery disease, heart failure, heart attacks, valve disease, cardiac surgery, dysrhythmias, aneurysms, embolism, strokes, peripheral vascular disease and hypertension. Current methods for diagnosis and predicting outcome in patients are limited and may lack accuracy. This study will collect clinical details, and blood and urine samples from patients for analysis of proteins, chemicals and genetic biomarkers which will enable an examination of the pathological mechanisms involved in cardiovascular disease. The data will also be used to improve diagnosis and also improve prediction of outcome in patients (future clinical events such as death, further hospitalisation with cardiovascular disease and the effects of any therapy given to the patients). In this way, we can develop accurate ways of assessing a patient's condition and how it could be effectively managed. The study will last for 20 years.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2010
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 17, 2010
CompletedFirst Submitted
Initial submission to the registry
May 13, 2020
CompletedFirst Posted
Study publicly available on registry
May 14, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 31, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
March 31, 2027
June 11, 2026
June 1, 2026
16.8 years
May 13, 2020
June 10, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
To improve understanding of disease mechanisms in cardiovascular disease
The principal objective is to improve upon our understanding of disease mechanisms in cardiovascular disease, using plasma and urine proteins or chemicals and a patient's genetic makeup, which may impact on the diagnosis and assessment of prognosis of cardiovascular disease.
20 Years
Secondary Outcomes (1)
To improve prediction of responses to different treatments, using blood proteins or chemicals and a patient's genetic makeup
20 Years
Study Arms (1)
1
Interventions
Eligibility Criteria
Participants recruited from secondary care, inpatient and outpatient departments.
You may qualify if:
- All outpatients and inpatients with cardiovascular disease, of either gender
- Aged 18-90 years old
- Examples of conditions include: coronary artery disease, heart failure, heart attacks (myocardial infarction), valve disease, cardiac surgery, dysrhythmias (including atrial fibrillation), aneurysms, embolism, strokes, peripheral vascular disease, hypertension (and its complications, such as left ventricular hypertrophy) or those presenting with chest pain
- Healthy volunteers
- Aged 18-90 years old
- From the community without cardiovascular or other diseases
You may not qualify if:
- Any patient who is unable to give consent
- Any patient with non-cardiovascular comorbidity likely to cause death within 6 months
- Patients know to be infected with HIV, Hepatitis B or any other agent posing an infection risk from unfixed material
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University Hospitals, Leicesterlead
- University of Leicestercollaborator
Study Sites (1)
University Hospitals Leicester
Leicester, United Kingdom
MeSH Terms
Conditions
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Nilesh J Samani, Professor
NIHR Leicester Biomedical Research Centre
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 13, 2020
First Posted
May 14, 2020
Study Start
June 17, 2010
Primary Completion (Estimated)
March 31, 2027
Study Completion (Estimated)
March 31, 2027
Last Updated
June 11, 2026
Record last verified: 2026-06
Data Sharing
- IPD Sharing
- Will not share