Molecular Screening for Lynch Syndrome in Denmark
1 other identifier
observational
5,000
1 country
11
Brief Summary
A clinically applicably strategy for molecular screening for Lynch Syndrome is being implemented in Denmark. Based on sequential analysis with immunohistochemistry and methylation analysis, patients with possible hereditary colorectal cancer are identified. These patients are offered genetic risk assessment and counselling. The study hypothesis is that molecular screening will identify more patients with Lynch Syndrome than the family history alone. Prospective data collection is performed using established clinical databases.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2012
Longer than P75 for all trials
11 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2012
CompletedFirst Submitted
Initial submission to the registry
April 30, 2013
CompletedFirst Posted
Study publicly available on registry
May 3, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2019
CompletedJanuary 23, 2020
January 1, 2020
2.3 years
April 30, 2013
January 22, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Rate of Lynch Syndrome in a population of primary colorectal cancer
1 year
Study Arms (1)
All colorectal cancer patients
Interventions
Eligibility Criteria
All colorectal cancer patients in Denmark
You may qualify if:
- Histological diagnosis of colorectal adenocarcinoma
- Diagnosed at one of the departments of pathology in Denmark
You may not qualify if:
- None
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Vejle Hospitallead
Study Sites (11)
Department of Pathology
Aalborg, Denmark
Department of Clinical Genetics
Aarhus, Denmark
Department of Pathology
Aarhus, Denmark
Department of Pathology
Esbjerg, Denmark
Department of Pathology
Hjørring, Denmark
Department of Clinical Genetics
Odense, Denmark
Department of Pathology
Odense, Denmark
Department of Pathology
Sønderborg, Denmark
Vejle Hospital
Vejle, 7100, Denmark
Department of Clinical Genetics
Vejle, Denmark
Department of Pathology
Vejle, Denmark
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 30, 2013
First Posted
May 3, 2013
Study Start
October 1, 2012
Primary Completion
February 1, 2015
Study Completion
December 31, 2019
Last Updated
January 23, 2020
Record last verified: 2020-01