Effect of Prolonged Military Exercises With High Load Carriage, on Neuromuscular Fatigue and Physiological/Biomechanical Responses

NCT01127191 | Completed DMC

• 2 other identifiers: 09011102009-A01346-51
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Land military missions generally combine prolonged walking/moderate-pace-running and other physical actions such as creeping, jumping, shooting,… which are associated with the direct carrying of high to severe loads of equipment and supplies (20-30 to 50 kg) by soldiers. For an infantry section, "typical" intervention phases last about 20-24 h and combine variable intensity grades. Consequently, military mission characteristics are an interesting investigation field of human fatigue. Previous studies have investigated human neuromuscular alterations after prolonged "normal" locomotion exercises \[Millet et al., 2004, 2009\], thus the aim of this study is to characterize the neuromuscular determinants of fatigue induced by a 24-h Simulated Military Effort (SME) and a 4-h Military Road March (MM), both performed with high load carriage. Additionally, the consequences of fatigue on physiological and biomechanical parameters of locomotion will be investigated.

Conditions

Healthy

Keywords

military exercises; neuromuscular fatigue; physiological responses; biomechanical responses; simulated military effort; high load carriage; Healthy voluntary

Outcome Measures

Primary Outcomes (2)

• Central fatigue quantification based on voluntary and electrically-induced force measurement on activated muscle.

  after a a military exercise of 24 hours

• Peripheral fatigue based on electrically-induced force measurement on the same muscle in relaxed condition.

  after a a military exercise of 24 hours

Secondary Outcomes (8)

• Oxygen uptake, carbon-dioxide output, energetic-cost of locomotion and respiratory ratio, based on subject's gas exchanges.

  after a a military exercise of 24 hours

• Lactatemia, based on subject's arterialized capillary blood samples analysis

  after a a military exercise of 24 hours

• Muscular electrical activities, based on subject's surface EMG analysis

  after a a military exercise of 24 hours

• Heart rate frequence

  after a a military exercise of 24 hours

• Walking and running mechanics, measured by an instrumented treadmill

  after a a military exercise of 24 hours

Study Arms (1)

Military

Other: military equipment

Interventions

military equipment OTHER

Military exercise of 24 hours

Military

Eligibility Criteria

• Age: 30 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

military retreated from national army

You may qualify if:

• to be a male
• to have a VO2max \> 45ml/min/kg (mean observed value in military subjects)
• to be aged from 30 to 45
• to be recently retreated from National Army
• to be highly experienced in military efforts
• to be trained in exercises involving load carrying
• to benefit from a social security insurance

You may not qualify if:

• All subjects with recent (\< 3 month) bone, articular or muscle diseases.
• All subjects presenting a clinic sign of intolerance to testing procedures, especially subjects with knee, ankle, hip or back diseases.
• All subjects intolerant to muddy or wooded environment.
• All subjects presenting a clinic sign of intolerance to exercise, and particularly to running or walking while carrying a load
• All subjects involved at the same time in another medical research
• All subjects militarily active
• All subjects with cardiac or pulmonary identified and known diseases

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Saint Etienne: lead

Study Sites (1)

CHU de Saint-Etienne

Saint-Etienne, 42055, France

Location

Related Publications (1)

• Grenier JG, Millet GY, Peyrot N, Samozino P, Oullion R, Messonnier L, Morin JB. Effects of extreme-duration heavy load carriage on neuromuscular function and locomotion: a military-based study. PLoS One. 2012;7(8):e43586. doi: 10.1371/journal.pone.0043586. Epub 2012 Aug 22.

  PMID: 22927995 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Lactatemia, based on subject's arterialized capillary blood samples analysis.

Study Officials

• Roger OULLION, Dr

  CHU SAINT-ETIENNE

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 11, 2010
• First Posted: May 20, 2010
• Study Start: March 1, 2010
• Primary Completion: April 1, 2010
• Study Completion: April 1, 2010
• Last Updated: July 25, 2012

Record last verified: 2012-07

Locations

FR (1)