NCT00962117|CompletedDMC
Relationship Between Dopamine Genetics, Food Reinforcement, Energy Intake and Obesity
Food Reinforcement Genotype Interactions and Eating
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Food Reinforcement Genotype Interactions and Eating
Sponsor study identifier
Secondary identifiers
observational
310
0 countries
N/A
Study Start
February 2008
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
June 2011
Actual (reported)Study Completion
June 2011
Actual (reported)The purpose of the study is to determine whether the presentation of various foods produces an increase or decrease in responses on a motivational computer task. In addition, the study determines if energy intake or motivation to obtain food is related to the dopamine receptor genotype.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 2011
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 2008
Date type not reportedThis date has not been verified as actual or estimated.
August 17, 2009
Actual (reported)August 19, 2009
Actual (reported)June 2011
Actual (reported)June 2011
Actual (reported)Subjects will be recruited from newspaper ads, posters on campus and in community settings, web based recruitment (ads on Craig's list and on the department's website) and direct mail targeted to community residents between 18-50 years of age.
Lin H, Carr KA, Fletcher KD, Epstein LH. Food reinforcement partially mediates the effect of socioeconomic status on body mass index. Obesity (Silver Spring). 2013 Jul;21(7):1307-12. doi: 10.1002/oby.20158. Epub 2013 Jun 11.
Epstein LH, Carr KA, Lin H, Fletcher KD, Roemmich JN. Usual energy intake mediates the relationship between food reinforcement and BMI. Obesity (Silver Spring). 2012 Sep;20(9):1815-9. doi: 10.1038/oby.2012.2. Epub 2012 Jan 13.
Saliva DNA samples will be collected from all participants
Leonard H Epstein, Ph.D.
SUNY Buffalo
310 participants (actual enrollment reported by the registry).
First Submitted
August 17, 2009
First Posted
August 19, 2009
Study Start
February 2008
Date type not reportedThis date has not been verified as actual or estimated.
Discordance of Obesity in Adolescent Sibilngs
Contact the study team to confirm eligibility.
Epstein LH, Lin H, Carr KA, Fletcher KD. Food reinforcement and obesity. Psychological moderators. Appetite. 2012 Feb;58(1):157-62. doi: 10.1016/j.appet.2011.09.025. Epub 2011 Oct 8.
Epstein LH, Carr KA, Lin H, Fletcher KD. Food reinforcement, energy intake, and macronutrient choice. Am J Clin Nutr. 2011 Jul;94(1):12-8. doi: 10.3945/ajcn.110.010314. Epub 2011 May 4.
Primary Completion
June 2011
Actual (reported)Study Completion
June 2011
Actual (reported)Last Updated
June 13, 2012
Record last verified: 2012-06
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Source: ClinicalTrials.gov.
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