Relationship Between Dopamine Genetics, Food Reinforcement, Energy Intake and Obesity

NCT00962117 | Completed DMC

• 2 other identifiers: 10669371066937-1-44786
• Study Type: observational
• Target: 310
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of the study is to determine whether the presentation of various foods produces an increase or decrease in responses on a motivational computer task. In addition, the study determines if energy intake or motivation to obtain food is related to the dopamine receptor genotype.

Conditions

Obesity

Keywords

Food Reinforcement; Energy Intake; Obesity; Dopamine

Study Arms (1)

Obese/Non-obese

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Subjects will be recruited from newspaper ads, posters on campus and in community settings, web based recruitment (ads on Craig's list and on the department's website) and direct mail targeted to community residents between 18-50 years of age.

You may qualify if:

• Non-smokers
• years of age
• No known eating disorder
• Moderate liking for study foods
• No current diagnosis of psychiatric disorder (e.g., anxiety or depression)
• Not on medications that would interfere with appetite (e.g., methylphenidate) or dopaminergic activity
• Non-diabetics

You may not qualify if:

• Smoker
• Pregnant women
• Current diagnosis of a psychiatric or eating disorder
• Dietary restrictions that would interfere with participation
• On medications that could interfere with appetite or olfactory responsiveness or use of antidepressants or any medication or dietary supplement that could affect appetite or dopaminergic activity
• Excessive use of alcohol (\>21 drinks/week), alcoholism,current addiction to opiates, cocaine or stimulants

Sponsors & Collaborators

• State University of New York at Buffalo: lead

Related Publications (4)

• Lin H, Carr KA, Fletcher KD, Epstein LH. Food reinforcement partially mediates the effect of socioeconomic status on body mass index. Obesity (Silver Spring). 2013 Jul;21(7):1307-12. doi: 10.1002/oby.20158. Epub 2013 Jun 11.

  PMID: 23754824 DERIVED

• Epstein LH, Carr KA, Lin H, Fletcher KD, Roemmich JN. Usual energy intake mediates the relationship between food reinforcement and BMI. Obesity (Silver Spring). 2012 Sep;20(9):1815-9. doi: 10.1038/oby.2012.2. Epub 2012 Jan 13.

  PMID: 22245983 DERIVED

• Epstein LH, Lin H, Carr KA, Fletcher KD. Food reinforcement and obesity. Psychological moderators. Appetite. 2012 Feb;58(1):157-62. doi: 10.1016/j.appet.2011.09.025. Epub 2011 Oct 8.

  PMID: 22005184 DERIVED

• Epstein LH, Carr KA, Lin H, Fletcher KD. Food reinforcement, energy intake, and macronutrient choice. Am J Clin Nutr. 2011 Jul;94(1):12-8. doi: 10.3945/ajcn.110.010314. Epub 2011 May 4.

  PMID: 21543545 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Saliva DNA samples will be collected from all participants

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Leonard H Epstein, Ph.D.

  SUNY Buffalo

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: SUNY Distinguished Professor of Pediatrics and Social and Preventive Medicine

Study Record Dates

• First Submitted: August 17, 2009
• First Posted: August 19, 2009
• Study Start: February 1, 2008
• Primary Completion: June 1, 2011
• Study Completion: June 1, 2011
• Last Updated: June 13, 2012

Record last verified: 2012-06