NCT00837694

Brief Summary

Food reinforcement, motivation to obtain food, is associated with energy intake and obesity. Finding ways to decrease the reinforcing value of unhealthy foods may help with adherence to diets and weight loss. Our previous study in non-obese adults showed that daily consumption of the same snack food (food typically consumed outside of meals) for 14 days significantly decreased its reinforcing value. The purpose of this study was to replicate and extend these findings to obese individuals as well as to examine effects of different portion sizes of snack foods on food reinforcement. Thirty-one obese (body mass index \> 30 kg/m2) and 27 non-obese (BMI \< 30 kg/m2) women had food reinforcement and liking tested at baseline and after two weeks of daily consumption of either 0 kcal, 100 kcals, or 300 kcals daily of the same snack food.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
65

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started May 2007

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2007

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2008

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

February 3, 2009

Completed
2 days until next milestone

First Posted

Study publicly available on registry

February 5, 2009

Completed
10.5 years until next milestone

Results Posted

Study results publicly available

August 1, 2019

Completed
Last Updated

August 1, 2019

Status Verified

June 1, 2019

Enrollment Period

1.1 years

First QC Date

February 3, 2009

Results QC Date

March 24, 2011

Last Update Submit

June 7, 2019

Conditions

Obesity

Keywords

BMIobesitysensitizationfood reinforcementsnack foodPortion size of daily snacksWeight status

Outcome Measures

Primary Outcomes (2)

  • Number of Responses Made by Clicking a Mouse Button for Food

    Participants were asked to click a button on a computer mouse and after a certaion number of responses, participants would receive a point. After 5 points, the participants received a portion of snack food.

    During 2nd and 3rd visits

  • Energy Intake

    energy contained in eaten foods and beverages

    visits 1, 2, and 3 plus on the phone throughout the study.

Secondary Outcomes (2)

  • Body Weight

    visit 1 and visit 3

  • Height

    visits 1 and 3

Study Arms (6)

1

Non-obese/0 kcal

2

Non-obese/100 kcal

3

Non-obese/300 kcal

4

Obese/0 kcal

5

Obese/100 kcal

6

Obese/300 kcal

Eligibility Criteria

Age18 Years - 50 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Women ages 18 - 50 years who were obese (body mass index \>/= 30) or non-obese (BMI \< 30)

You may qualify if:

  • women
  • non-smoker
  • not on a diet
  • no restrained eating
  • had to like potential snack foods
  • willing to visit the laboratory 3 times
  • willing to eat snacks provided
  • no medications or medical conditions that affect appetite
  • no food allergies

You may not qualify if:

  • see above

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University at Buffalo

Buffalo, New York, 14214, United States

Location

Related Publications (1)

  • Temple JL, Bulkley AM, Badawy RL, Krause N, McCann S, Epstein LH. Differential effects of daily snack food intake on the reinforcing value of food in obese and nonobese women. Am J Clin Nutr. 2009 Aug;90(2):304-13. doi: 10.3945/ajcn.2008.27283. Epub 2009 May 20.

    PMID: 19458018DERIVED

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Limitations and Caveats

One limitation was that we relied on self-report for energy and snack food intake. It is possible that people were not eating the food that they said they were. Another limitation was that people may have not understood the task.

Results Point of Contact

Title
Jennifer L. Temple
Organization
University at Buffalo
jltemple@buffalo.edu
716-829-5593

Study Officials

  • Jennifer L Temple, Ph.D.

    University at Buffalo

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

February 3, 2009

First Posted

February 5, 2009

Study Start

May 1, 2007

Primary Completion

June 1, 2008

Study Completion

June 1, 2008

Last Updated

August 1, 2019

Results First Posted

August 1, 2019

Record last verified: 2019-06

Locations

US(1)