Developmental Adaptation to an Obesogenic Environment
Developmental Contribution to Macronutrient Selection and Appetite Control in Adult Survivors of Kwashiorkor and Marasmus
1 other identifier
interventional
63
0 countries
N/A
Brief Summary
The purpose of this study was to evaluate whether birth weight is related to the demand for dietary protein in adult survivors of severe acute malnutrition (Kwashiorkor and Marasmus), and that leveraging of protein intake is associated with total energy intake and weight change in the survivors consuming foods with different percentages of energy as protein (PEP).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable obesity
Started May 2009
Typical duration for not_applicable obesity
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2012
CompletedFirst Submitted
Initial submission to the registry
October 1, 2014
CompletedFirst Posted
Study publicly available on registry
October 6, 2014
CompletedOctober 6, 2014
October 1, 2014
3.1 years
October 1, 2014
October 3, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Energy intake (Protein leverage)
Total energy intake when placed on 10, 15 or 25% protein energy diet
5 days
Secondary Outcomes (1)
Weight change
5 days
Other Outcomes (1)
Protein intake (protein target)
3 days
Study Arms (3)
10 % Protein
EXPERIMENTAL10% Dietary protein energy
15% Protein
EXPERIMENTAL15% Dietary protein energy
25% Protein
EXPERIMENTAL25% Dietary protein energy
Interventions
Persons were fed Participants were randomized to one of three arms, each of which received 10%, 15% or 25% of total energy derived from protein
Eligibility Criteria
You may qualify if:
- Adults who were treated for severe childhood malnutrition at the Tropical Metabolism Research Unit
You may not qualify if:
- Diabetes, hypertension, pregnancy,
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (2)
Gosby AK, Soares-Wynter S, Campbell C, Badaloo A, Antonelli M, Hall RM, Martinez-Cordero C, Jebb SA, Brand-Miller J, Caterson ID, Conigrave AD, Forrester TG, Raubenheimer D, Simpson SJ. Design and testing of foods differing in protein to energy ratios. Appetite. 2010 Oct;55(2):367-70. doi: 10.1016/j.appet.2010.06.009. Epub 2010 Jun 19.
PMID: 20600416BACKGROUNDForrester TE, Badaloo AV, Boyne MS, Osmond C, Thompson D, Green C, Taylor-Bryan C, Barnett A, Soares-Wynter S, Hanson MA, Beedle AS, Gluckman PD. Prenatal factors contribute to the emergence of kwashiorkor or marasmus in severe undernutrition: evidence for the predictive adaptation model. PLoS One. 2012;7(4):e35907. doi: 10.1371/journal.pone.0035907. Epub 2012 Apr 30.
PMID: 22558267BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Terrence G Forrester, MBBS, PhD
University of the West Indies, Mona
- PRINCIPAL INVESTIGATOR
David Raubenheimer, PhD
University of Aukland
- PRINCIPAL INVESTIGATOR
Claudia P Campbell, PhD
University of the West Indies, Mona
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr. Claudia Patricia Campbell
Study Record Dates
First Submitted
October 1, 2014
First Posted
October 6, 2014
Study Start
May 1, 2009
Primary Completion
June 1, 2012
Study Completion
June 1, 2012
Last Updated
October 6, 2014
Record last verified: 2014-10