Lifestyle Intervention for Heart Failure
Take Heart: Exercise & Diet Intervention for Heart Failure in Cancer Survivors
2 other identifiers
interventional
85
1 country
2
Brief Summary
The goal of this behavioral research study is to learn if education and training about exercise can help to change the lifestyle of cancer survivors with symptoms of heart failure.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable heart-failure
Started Feb 2008
Longer than P75 for not_applicable heart-failure
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 11, 2008
CompletedFirst Submitted
Initial submission to the registry
March 5, 2008
CompletedFirst Posted
Study publicly available on registry
March 12, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 31, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
May 31, 2026
CompletedJanuary 14, 2026
January 1, 2026
18.3 years
March 5, 2008
January 13, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Recruitment/Attendance/Drop-Out Rates
1 Year
Study Arms (2)
Group 1
OTHERUsual Care
Group 2
EXPERIMENTALExercise Training + Dietary Counseling
Interventions
Monthly visits with the cardiology team and a booklet about coping with heart failure.
Food log, booklet, and a cookbook to help decrease the salt content in your diet.
Eligibility Criteria
You may qualify if:
- diagnosis of NYHA I, II or III heart failure (as identified by any of the following physical findings of heart failure (jugular venous distension, crackles, edema, S3); pulmonary edema on chest x-ray; BNP \> 100 pg/ml; or at least two of the following symptoms: paroxysmal nocturnal dyspnea, shortness of breath, swelling, fatigue;
- previous chemotherapy that contributed to the development of heart failure (i.e., heart failure develops or worsens after receiving chemotherapy, with no other obvious explanation);
- oriented to person, place, and time;
- living in the Houston area (Harris county or a contiguous county), or planning to stay in the area for at least the next 16 weeks.
- years of age or older.
- diagnosis of cancer
- have completed treatment, or are on long-term adjuvant or maintenance chemotherapy only
You may not qualify if:
- remain in NYHA class IV heart failure despite therapy;
- have health problems or current treatments that would make exercise unsafe, as determined by the cardiologist;
- cannot provide informed consent;
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
The University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78249, United States
Related Publications (1)
Tsai E, Mouhayar E, Lenihan D, Song J, Durand JB, Fadol A, Massey M, Harrison C, Basen-Engquist K. Feasibility and Outcomes of an Exercise Intervention for Chemotherapy-Induced Heart Failure. J Cardiopulm Rehabil Prev. 2019 May;39(3):199-203. doi: 10.1097/HCR.0000000000000388.
PMID: 31022003DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Karen Basen-Engquist, PhD
M.D. Anderson Cancer Center
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 5, 2008
First Posted
March 12, 2008
Study Start
February 11, 2008
Primary Completion
May 31, 2026
Study Completion
May 31, 2026
Last Updated
January 14, 2026
Record last verified: 2026-01