NCT00488631

Brief Summary

The purpose of this study is to assess the safety and efficacy of golimumab administered subcutaneously (under the skin) injections in maintenance therapy.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
1,228

participants targeted

Target at P75+ for phase_3

Timeline
Completed

Started Sep 2007

Longer than P75 for phase_3

Geographic Reach
24 countries

292 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 18, 2007

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 20, 2007

Completed
2 months until next milestone

Study Start

First participant enrolled

September 1, 2007

Completed
4.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2011

Completed
2.1 years until next milestone

Results Posted

Study results publicly available

November 11, 2013

Completed
1.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2015

Completed
Last Updated

April 26, 2016

Status Verified

March 1, 2016

Enrollment Period

4.1 years

First QC Date

June 18, 2007

Results QC Date

May 1, 2013

Last Update Submit

March 24, 2016

Conditions

Keywords

Colitis, UlcerativeGolimumabCNTO 148

Outcome Measures

Primary Outcomes (1)

  • Number of Participants in Clinical Response Through Week 54

    Clinical response is defined as decrease from induction baseline in Mayo score by greater than or equal to (\>=) 30 percent and \>= 3, with either decrease from induction baseline in rectal bleeding subscore of \>= 1 or rectal bleeding subscore of 0 or 1. Participants who lost clinical response prior to Week 54 were considered not to meet endpoint. Mayo score is sum of 4 subscores (ie, stool frequency, rectal bleeding, endoscopic findings, physician's global assessment); each rated on scale from 0 to 3, with higher scores indicating more severe disease. Total Mayo score value ranges from 0 to 12.

    Induction Baseline, Week 0 through Week 54

Secondary Outcomes (4)

  • Number of Participants With Clinical Remission at Both Week 30 and Week 54

    Week 30 and Week 54

  • Number of Participants With Mucosal Healing at Both Week 30 and Week 54

    Week 30 and Week 54

  • Number of Participants With Clinical Remission at Both Week 30 and 54 Among Participants With Clinical Remission at Week 0 of Maintenance Study

    Week 30 and Week 54

  • Number of Participants With Clinical Remission at Week 54 and Not Receiving Concomitant Corticosteroids Among Participants on Corticosteroids at Week 0 of Maintenance Study

    Week 54

Study Arms (6)

Golimumab induction responders (GLM-I-Rsp)-Placebo Maintenance

PLACEBO COMPARATOR

Participants in clinical response to golimumab at Week 6 of induction study C0524T16 (NCT00488774) or C0524T17 (NCT00487539) and randomized to placebo subcutaneous (under the skin) injection matching to golimumab administered every 4 weeks through Week 52 in maintenance study C0524T18 (NCT00488631). Participants with loss of clinical response will have their dose increased to golimumab 100 mg subcutaneous injection administered every 4 weeks through Week 52.

Biological: PlaceboBiological: Golimumab 100 mg

GLM-I-Rsp-Golimumab 50 mg Maintenance

EXPERIMENTAL

Participants in clinical response to golimumab at Week 6 of induction study C0524T16 (NCT00488774) or C0524T17 (NCT00487539) and randomized to golimumab 50 mg subcutaneous injection administered every 4 weeks through Week 52 in maintenance study C0524T18 (NCT00488631). Participants with loss of clinical response will be re-randomized to receive golimumab 50 mg or 100 mg subcutaneous injections every 4 weeks through Week 52.

Biological: Golimumab 50 mgBiological: Golimumab 100 mg

GLM-I-Rsp-Golimumab 100 mg Maintenance

EXPERIMENTAL

Participants in clinical response to golimumab at Week 6 of induction study C0524T16 (NCT00488774) or C0524T17 (NCT00487539) and randomized to golimumab 100 mg subcutaneous injection administered every 4 weeks through Week 52 in maintenance study C0524T18 (NCT00488631). Participants with loss of clinical response will be re-randomized to receive golimumab 100 mg or 200 mg subcutaneous injections every 4 weeks through Week 52.

Biological: Golimumab 100 mgBiological: Golimumab 200 mg

Placebo induction responders (PBO-I-Rsp)-Placebo Maintenance

PLACEBO COMPARATOR

Participants in clinical response to placebo at Week 6 of induction study C0524T16 (NCT00488774) or C0524T17 (NCT00487539) and received placebo subcutaneous injection matching to golimumab administered every 4 weeks through Week 52 in maintenance study C0524T18 (NCT00488631); not randomized. Participants with loss of clinical response will have their dose increased to golimumab 100 mg subcutaneous injection administered every 4 weeks through Week 52.

Biological: PlaceboBiological: Golimumab 100 mg

PBO-I-nonRsp-Golimumab 100 mg Maintenance

EXPERIMENTAL

Participants not in clinical response to placebo at Week 6 induction study C0524T16 (NCT00488774) or C0524T17 (NCT00487539) and received golimumab 100 mg subcutaneous injection administered every 4 weeks through Week 52 in maintenance study C0524T18 (NCT00488631); not randomized.

Biological: Golimumab 100 mg

GLM-I-nonRsp-Golimumab 100 mg Maintenance

EXPERIMENTAL

Participants not in clinical response to golimumab at Week 6 of induction study and received golimumab 100 mg subcutaneous injection administered every 4 weeks through Week 52 in maintenance study C0524T18 (NCT00488631); not randomized.

Biological: Golimumab 100 mg

Interventions

PlaceboBIOLOGICAL

Participants receive placebo subcutaneous injection matching to golimumab administered every 4 weeks through Week 52 in the maintenance study C0524T18 (NCT00488631).

Golimumab induction responders (GLM-I-Rsp)-Placebo MaintenancePlacebo induction responders (PBO-I-Rsp)-Placebo Maintenance
Golimumab 50 mgBIOLOGICAL

Participants receive golimumab 50 mg subcutaneous injection administered every 4 weeks through Week 52 in the maintenance study C0524T18 (NCT00488631).

GLM-I-Rsp-Golimumab 50 mg Maintenance

Participants receive golimumab 100 mg subcutaneous injection administered every 4 weeks through Week 52 in the maintenance study C0524T18 (NCT00488631) initially or after dose adjustment following loss of clinical response.

GLM-I-Rsp-Golimumab 100 mg MaintenanceGLM-I-Rsp-Golimumab 50 mg MaintenanceGLM-I-nonRsp-Golimumab 100 mg MaintenanceGolimumab induction responders (GLM-I-Rsp)-Placebo MaintenancePBO-I-nonRsp-Golimumab 100 mg MaintenancePlacebo induction responders (PBO-I-Rsp)-Placebo Maintenance

Participants receiving golimumab 100 mg initially who on loss of clinical response receive golimumab 200 mg administered every 4 weeks through Week 52.

GLM-I-Rsp-Golimumab 100 mg Maintenance

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Participants who received all study agent administrations and completed the Week 6 Mayo score evaluation in induction study C0524T16 (NCT00488774) or C0524T17 (NCT00487539)
  • Participants who completed the Week 0 visit for this maintenance study C0524T18 (NCT00488631) on the same day as the Week 6 visit of the induction study C0524T16 (NCT00488774) or C0524T17 (NCT00487539)

You may not qualify if:

  • Participants who increased the dose of their concomitant (given at the same time) UC medications since Week 0 of induction study C0524T16 (NCT00488774) or C0524T17 (NCT00487539)
  • Participants who initiated a concomitant UC medication since Week 0 of an induction study C0524T16 (NCT00488774) or C0524T17 (NCT00487539)
  • Participants who had a partial or total colectomy (surgery to remove part or all of the colon) or an ostomy (surgical construction of an artificial opening (stoma) for external fistulization of a duct or vessel by insertion of a tube with or without a supportive stent) since Week 0 of an induction study C0524T16 (NCT00488774) or C0524T17 (NCT00487539)
  • Participants with signs or symptoms of latent or active granulomatous infection (including TB); a nontuberculous mycobacterial infection or opportunistic infection; or infection with HIV (Human Immunodeficiency Virus), hepatitis B, or hepatitis C
  • Participants with signs and symptoms of any malignancy or suggestive of a possible lymphoproliferative disease (disorders characterized by proliferation of lymphoid tissue, general or unspecified)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (297)

Unknown Facility

Birmingham, Alabama, United States

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Little Rock, Arkansas, United States

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Anaheim, California, United States

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Merced, California, United States

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Orange, California, United States

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Roseville, California, United States

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San Diego, California, United States

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Lakewood, Colorado, United States

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Littleton, Colorado, United States

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Bristol, Connecticut, United States

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Newark, Delaware, United States

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Boca Raton, Florida, United States

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Gainesville, Florida, United States

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Hialeah, Florida, United States

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Hollywood, Florida, United States

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Jacksonville, Florida, United States

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Naples, Florida, United States

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New Port Richey, Florida, United States

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North Miami Beach, Florida, United States

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Port Orange, Florida, United States

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Tampa, Florida, United States

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Winter Park, Florida, United States

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Zephyrhills, Florida, United States

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Atlanta, Georgia, United States

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Decatur, Georgia, United States

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Savannah, Georgia, United States

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Snellville, Georgia, United States

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Arlington Heights, Illinois, United States

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Chicago, Illinois, United States

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Clive, Iowa, United States

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Fort Dodge, Iowa, United States

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Pratt, Kansas, United States

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Topeka, Kansas, United States

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Lexington, Kentucky, United States

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Louisville, Kentucky, United States

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Monroe, Louisiana, United States

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Hagerstown, Maryland, United States

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Hollywood, Maryland, United States

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Laurel, Maryland, United States

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Worcester, Massachusetts, United States

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Ann Arbor, Michigan, United States

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Dearborn, Michigan, United States

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Troy, Michigan, United States

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Plymouth, Minnesota, United States

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Rochester, Minnesota, United States

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Pascagoula, Mississippi, United States

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Tupelo, Mississippi, United States

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Urbana, Missouri, United States

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Las Vegas, Nevada, United States

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Lebanon, New Hampshire, United States

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Egg Harbor, New Jersey, United States

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Great Neck, New York, United States

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Huntington, New York, United States

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New York, New York, United States

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Rochester, New York, United States

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Asheville, North Carolina, United States

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Boone, North Carolina, United States

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Charlotte, North Carolina, United States

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Harrisburg, North Carolina, United States

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Kinston, North Carolina, United States

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Morganton, North Carolina, United States

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New Bern, North Carolina, United States

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Raleigh, North Carolina, United States

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Wilmington, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Fargo, North Dakota, United States

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Cincinnati, Ohio, United States

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Cleveland, Ohio, United States

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Colombus, Ohio, United States

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Norman, Oklahoma, United States

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Oklahoma City, Oklahoma, United States

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Tulsa, Oklahoma, United States

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Portland, Oregon, United States

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Limerick, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Charleston, South Carolina, United States

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Columbia, South Carolina, United States

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Germantown, Tennessee, United States

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Nashville, Tennessee, United States

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Austin, Texas, United States

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Dallas, Texas, United States

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Galveston, Texas, United States

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Houston, Texas, United States

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Logan, Utah, United States

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Ogden, Utah, United States

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Burlington, Vermont, United States

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Chesapeake, Virginia, United States

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Christiansburg, Virginia, United States

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Fairfax, Virginia, United States

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Richmond, Virginia, United States

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Bellevue, Washington, United States

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Seattle, Washington, United States

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Spokane, Washington, United States

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Tacoma, Washington, United States

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Madison, Wisconsin, United States

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Milwaukee, Wisconsin, United States

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Adelaide, Australia

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Bankstown, Australia

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Box Hill, Australia

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Brisbane, Australia

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Cairns, Australia

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Fitzroy, Australia

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Fremantle, Australia

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Herston, Australia

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Launceston, Australia

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Malvern, Australia

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Parkville, Australia

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Prahran, Australia

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Westmead, Australia

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Innsbruck, Austria

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Vienna, Austria

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Bonheiden, Belgium

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Brussels, Belgium

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Ghent, Belgium

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Leuven, Belgium

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Liège, Belgium

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Roeselare, Belgium

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Bulgaria, Bulgaria

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Pleven, Bulgaria

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Plovdiv, Bulgaria

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Rousse, Bulgaria

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Sofia, Bulgaria

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Calgary, Alberta, Canada

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Vancouver, British Columbia, Canada

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Victoria, British Columbia, Canada

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Winnipeg, Manitoba, Canada

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Barrie, Ontario, Canada

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Chatham, Ontario, Canada

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Hamilton, Ontario, Canada

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Kingston, Ontario, Canada

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London, Ontario, Canada

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Vaughan, Ontario, Canada

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Montreal, Quebec, Canada

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Québec, Quebec, Canada

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Saskatoon, Saskatchewan, Canada

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Toronto, Canada

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Windsor, Canada

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Èeské Budìjovice 1, Czechia

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Hradec Králové, Czechia

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Litoměřice, Czechia

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Ostrava, Czechia

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Aalborg, Denmark

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Aarhus C, Denmark

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Hvidovre, Denmark

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Odense C, Denmark

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Amiens Cedex 1 80, France

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Bordeaux, France

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Clichy, France

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Lille, France

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Marseille, France

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Nice, France

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Paris, France

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Rouen, France

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Aachen, Germany

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Berlin, Germany

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Berlin Be, Germany

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Bochum, Germany

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Frankfurt, Germany

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Hamburg, Germany

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Hanover, Germany

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Heidelberg, Germany

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Herne, Germany

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Jena, Germany

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Kiel, Germany

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Magdeburg, Germany

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Minden, Germany

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München, Germany

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Münster, Germany

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Neustadt, Germany

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Stade, Germany

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Balatonfüred, Hungary

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Budapest, Hungary

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Debrecen, Hungary

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Dunaújváros, Hungary

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Gyõr, Hungary

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Gyula, Hungary

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Gyulai Ut 18, Hungary

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Miskolc, Hungary

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Mosonmagyaróvár, Hungary

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Pécs, Hungary

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Siófok, Hungary

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Sopron, Hungary

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Szeged, Hungary

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Szekszárd, Hungary

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Székesfehérvár, Hungary

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Szombathely, Hungary

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Veszprém, Hungary

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Zalaegerszeg, Hungary

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Bangalore, India

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Chennai, India

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Hyderabad, India

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Hyderabad Andh Prad, India

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Jaipur, India

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Kārnād, India

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Lucknow Gpo, India

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Ludhiana, India

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New Delhi, India

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Pune, India

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Vishakapatanam, India

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Afula, Israel

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Beer Yaakov, Israel

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Beersheba, Israel

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Haifa, Israel

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Hedera, Israel

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Jerusalem, Israel

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Kfar Saba, Israel

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Kiryat Bialik, Israel

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Nazareth, Israel

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Petah-Tikv, Israel

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Rehovot, Israel

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Tel Aviv, Israel

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Tel Litwinsky, Israel

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Bunkyō City, Japan

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Chikushinoshi, Japan

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Fukuoka, Japan

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Hiroshima, Japan

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Kagoshima, Japan

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Kurashiki, Japan

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Kurume, Japan

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Nagoya, Japan

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Nishinomiya, Japan

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Okayama, Japan

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Osaka, Japan

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Sakura, Japan

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Sapporo, Japan

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Tokyo, Japan

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Yokkaichi, Japan

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Balvi, Latvia

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Daugavpils, Latvia

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Riga, Latvia

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Kaunas, Lithuania

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Klaipėda, Lithuania

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Šiauliai, Lithuania

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Vilnius, Lithuania

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Vilnius Lt, Lithuania

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Amsterdam, Netherlands

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Ede Gld, Netherlands

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Groningen, Netherlands

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Leiden, Netherlands

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Nieuwegein, Netherlands

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Rotterdam, Netherlands

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Auckland, New Zealand

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Christchurch, New Zealand

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Dunedin, New Zealand

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Hamilton, New Zealand

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Hastings, New Zealand

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Bialystok, Poland

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Bydgoszcz, Poland

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Częstochowa, Poland

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Elblag, Poland

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Gdansk, Poland

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Krakow, Poland

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Lodz, Poland

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Lublin, Poland

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Opole, Poland

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Skierniewice, Poland

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Sopot, Poland

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Szczecin, Poland

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Torun, Poland

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Warsaw, Poland

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Bucharest, Romania

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Cluj-Napoca, Romania

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Iași, Romania

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Târgu Mureş, Romania

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Timișoara, Romania

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Moscow, Russia

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Novosibirsk, Russia

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Omsk, Russia

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Saint Petersburg, Russia

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Smolensk, Russia

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Yaroslavl, Russia

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Belgrade, Serbia

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Niš, Serbia

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Zemun, Serbia

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Bratislava, Slovakia

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Martin, Slovakia

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Nitra, Slovakia

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Nové Mesto nad Váhom, Slovakia

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Prešov, Slovakia

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Trnava, Slovakia

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Cape Town, South Africa

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Cape Town West Cape, South Africa

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Durban, South Africa

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Plumstead West Cape, South Africa

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Pretoria Gauteng, South Africa

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Gothenburg, Sweden

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Stockholm, Sweden

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Donetsk, Ukraine

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Ivano, Ukraine

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Kharkiv, Ukraine

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Kiev, Ukraine

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Kyiv, Ukraine

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Lviv, Ukraine

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Poltava, Ukraine

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Simferopol, Ukraine

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Vinnitsa, Ukraine

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Zhaporozhia 69104, Ukraine

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Related Publications (6)

  • Weinstein CLJ, Meehan AG, Govoni M, Lin J, Reinisch W. Low Occurrence of Colectomy With Long-Term (up to 4 Years) Golimumab Treatment in Patients With Moderate-to-Severe Active Ulcerative Colitis: Data From the PURSUIT Maintenance and Long-Term Extension Studies. Crohns Colitis 360. 2023 Aug 26;5(3):otad044. doi: 10.1093/crocol/otad044. eCollection 2023 Jul.

  • Perrig K, Krupka N, Jordi SBU, Rossel JB, Biedermann L, Greuter T, Schreiner P, Vavricka SR, Juillerat P, Burri E, Zimmermann D, Maillard MH, Sulz MC, Brand S, Rogler G, Misselwitz B. Effectiveness of golimumab in patients with ulcerative colitis: results of a real-life study in Switzerland. Therap Adv Gastroenterol. 2022 Feb 9;15:17562848221074188. doi: 10.1177/17562848221074188. eCollection 2022.

  • Adedokun OJ, Xu Z, Liao S, Strauss R, Reinisch W, Feagan BG, Sandborn WJ. Population Pharmacokinetics and Exposure-Response Modeling of Golimumab in Adults With Moderately to Severely Active Ulcerative Colitis. Clin Ther. 2020 Jan;42(1):157-174.e4. doi: 10.1016/j.clinthera.2019.11.010. Epub 2020 Jan 22.

  • Philip G, Cornillie F, Adedokun JO, Melsheimer R, Rutgeerts P, Colombel JF, Marano C. Early Dose Optimisation of Golimumab in Nonresponders to Induction Treatment for Ulcerative Colitis Is Effective and Supported by Pharmacokinetic Data. J Crohns Colitis. 2019 Sep 27;13(10):1257-1264. doi: 10.1093/ecco-jcc/jjz052.

  • Reinisch W, Gibson PR, Sandborn WJ, Feagan BG, Strauss R, Johanns J, Padgett L, Adedokun OJ, Colombel JF, Collins J, Rutgeerts P, Tarabar D, Marano C. Long-Term Benefit of Golimumab for Patients with Moderately to Severely Active Ulcerative Colitis: Results from the PURSUIT-Maintenance Extension. J Crohns Colitis. 2018 Aug 29;12(9):1053-1066. doi: 10.1093/ecco-jcc/jjy079.

  • Sandborn WJ, Feagan BG, Marano C, Zhang H, Strauss R, Johanns J, Adedokun OJ, Guzzo C, Colombel JF, Reinisch W, Gibson PR, Collins J, Jarnerot G, Rutgeerts P; PURSUIT-Maintenance Study Group. Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcerative colitis. Gastroenterology. 2014 Jan;146(1):96-109.e1. doi: 10.1053/j.gastro.2013.06.010. Epub 2013 Jun 14.

MeSH Terms

Conditions

Colitis, Ulcerative

Interventions

golimumab

Condition Hierarchy (Ancestors)

ColitisGastroenteritisGastrointestinal DiseasesDigestive System DiseasesInflammatory Bowel DiseasesColonic DiseasesIntestinal Diseases

Results Point of Contact

Title
Senior Director
Organization
Janssen Research & Development

Study Officials

  • Janssen Research & Development, LLC Clinical Trial

    Janssen Research & Development, LLC

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 18, 2007

First Posted

June 20, 2007

Study Start

September 1, 2007

Primary Completion

October 1, 2011

Study Completion

February 1, 2015

Last Updated

April 26, 2016

Results First Posted

November 11, 2013

Record last verified: 2016-03

Locations