NCT00154518

Brief Summary

The purpose of this study is to test whether the two MMPs can be up-regulated during orthodontic treatment. Alveolar bone samples will be collected from partially impacted third molars after orthodontic uprighting for different periods of time in volunteers.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
12

participants targeted

Target at below P25 for phase_1

Timeline
Completed

Started Jan 2004

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2004

Completed
1.7 years until next milestone

First Submitted

Initial submission to the registry

September 9, 2005

Completed
3 days until next milestone

First Posted

Study publicly available on registry

September 12, 2005

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2005

Completed
Last Updated

February 22, 2013

Status Verified

February 1, 2013

First QC Date

September 9, 2005

Last Update Submit

February 20, 2013

Conditions

Tooth, ImpactedMolar, Third

Keywords

orthodontic tooth movementmatrix metalloproteinaseOrthodontics

Outcome Measures

Primary Outcomes (1)

  • Tissue staining with antibody

Interventions

Orthodontic treatmentPROCEDURE

Eligibility Criteria

Age18 Years - 35 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Two mandibular third molars containing at least one mesially angular impaction with crown exposed to oral cavity

You may not qualify if:

  • Pregnancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Dentistry, National Taiwan University Hospital

Taipei, Taiwan

Location

MeSH Terms

Conditions

Tooth, Impacted

Interventions

Orthodontics

Condition Hierarchy (Ancestors)

Tooth DiseasesStomatognathic Diseases

Intervention Hierarchy (Ancestors)

Dentistry

Study Officials

  • Chung-Chen Yao, DDS, PhD

    National Taiwan University Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 1
Allocation
NON RANDOMIZED
Masking
SINGLE
Purpose
TREATMENT
Intervention Model
FACTORIAL
Sponsor Type
OTHER

Study Record Dates

First Submitted

September 9, 2005

First Posted

September 12, 2005

Study Start

January 1, 2004

Study Completion

December 1, 2005

Last Updated

February 22, 2013

Record last verified: 2013-02

Locations

TW(1)