NCT00155311

Brief Summary

To test whether levels of OPG can be changed during orthodontic treatment. Alveolar bone samples will be collected from partially impacted third molars after orthodontic uprighting for different period of time in volunteers. In situ hybridization and immunohistochemistry analysis for OPG and RANKL will reveal their roles in this physiological process.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10

participants targeted

Target at below P25 for phase_1

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2005

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

September 8, 2005

Completed
4 days until next milestone

First Posted

Study publicly available on registry

September 12, 2005

Completed
3.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2008

Completed
Last Updated

March 15, 2013

Status Verified

March 1, 2013

Enrollment Period

3.9 years

First QC Date

September 8, 2005

Last Update Submit

March 14, 2013

Conditions

Malocclusion

Keywords

orthodontic tooth movementOPGRANKL

Outcome Measures

Primary Outcomes (1)

  • OPG staining

    at 1, 3, 7 days after orthodontic force application on wisdom teeth, bone covering the tooth will be removed before taking the wisdom tooth out. The tissue section of the bone will be done with immunocytochemistry after de-calicification.

    at most 7 days

Study Arms (1)

days after treatment

EXPERIMENTAL

different days after orthodontic treament, samples will be taken.

Procedure: orthodontic treatment

Interventions

orthodontic treatmentPROCEDURE
days after treatment

Eligibility Criteria

Age18 Years - 35 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • patients with two mandibular impaction third molars containing at least one mesially angular impaction with crown exposed to the oral cavity

You may not qualify if:

  • pregnancy or diseases with abnormal bone metabolism

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Dentistry, National Taiwan University Hospital

Taipei, Taiwan

Location

MeSH Terms

Conditions

Malocclusion

Interventions

Orthodontics

Condition Hierarchy (Ancestors)

Tooth DiseasesStomatognathic Diseases

Intervention Hierarchy (Ancestors)

Dentistry

Study Officials

  • Chung-Chen Yao, DDS, PhD

    National Taiwan University Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 1
Allocation
NON RANDOMIZED
Masking
SINGLE
Who Masked
INVESTIGATOR
Purpose
TREATMENT
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 8, 2005

First Posted

September 12, 2005

Study Start

January 1, 2005

Primary Completion

December 1, 2008

Last Updated

March 15, 2013

Record last verified: 2013-03

Locations

TW(1)