NCT06602518

Brief Summary

Aim of the study: is to compare the changes in the sagittal pharyngeal airway dimension (SPAD) and mandibular position before and after the levelling and alignment stage of orthodontic treatment in Class II division 2 patients.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
27

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jun 2024

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 20, 2024

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

September 15, 2024

Completed
4 days until next milestone

First Posted

Study publicly available on registry

September 19, 2024

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2025

Completed
Last Updated

September 19, 2024

Status Verified

September 1, 2024

Enrollment Period

7 months

First QC Date

September 15, 2024

Last Update Submit

September 15, 2024

Conditions

Outcome Measures

Primary Outcomes (1)

  • Changes in the sagittal pharyngeal airway space (SPAD)

    6 months

Secondary Outcomes (3)

  • Changes in the mandibular position

    6 months

  • Sagittal skeletal measurements

    6 months

  • Vertical skeletal measurements

    6 months

Study Arms (1)

Levelling and alignment

EXPERIMENTAL
Procedure: Orthodontic Treatment

Interventions

All the enrolled patients will undergo conventional fixed appliance therapy by bonding straight wire Roth appliance in the maxillary arch. The bonding procedure will be standardized in all patients and performed by the same operator using light-cured composite. Levelling and alignment will then be started using the following wire sequence: 0.014-in nickel titanium (NiTi), 0.018-in NiTi, 17×25-in Niti, and 19×25-in Niti arch wires. The upper arch will then be stabilized using a 19×25-in stainless steel (SS) arch wire for 2 months. This stage will require approximately 6 months of treatment.

Levelling and alignment

Eligibility Criteria

Age12 Years - 16 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Class II/2 subjects as per the British Standard Institute Classification.
  • Age ranging from 12-16 years, with Cervical Vertebral Maturational Index (CVMI) stages 4, and 5.
  • Contact between maxillary and mandibular incisors, with the presence of a deep bite of at least 70%.
  • Full permanent dentition, aside from the third molars

You may not qualify if:

  • Previous orthodontic treatment.
  • Patients with severe transverse problems, pain and/or clicking sound in the temporomandibular joint (TMJ).
  • Patients with craniofacial anomalies or diagnosed syndromes

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of Dentistry, Alexandria University

Alexandria, Egypt

RECRUITING

MeSH Terms

Conditions

Malocclusion, Angle Class II

Interventions

Orthodontics

Condition Hierarchy (Ancestors)

MalocclusionTooth DiseasesStomatognathic Diseases

Intervention Hierarchy (Ancestors)

Dentistry

Study Officials

  • Farah Y Eid, PhD

    Faculty of Dentistry, Alexandria University, Egypt

    PRINCIPAL INVESTIGATOR
  • Dina Elfouly, PhD

    Faculty of Dentistry, Alexandria University, Egypt

    STUDY DIRECTOR
  • Ahmed Madian, PhD

    Faculty of Dentistry, Alexandria University, Egypt

    STUDY CHAIR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Assistant Lecturer of Dental Public Health

Study Record Dates

First Submitted

September 15, 2024

First Posted

September 19, 2024

Study Start

June 20, 2024

Primary Completion

January 1, 2025

Study Completion

January 1, 2025

Last Updated

September 19, 2024

Record last verified: 2024-09

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