NCT00087893

Brief Summary

To investigate the relationship of vascular cell phenotypes to atherosclerosis.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
931

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jul 2004

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2004

Completed
14 days until next milestone

First Submitted

Initial submission to the registry

July 15, 2004

Completed
4 days until next milestone

First Posted

Study publicly available on registry

July 19, 2004

Completed
3.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2008

Completed
Last Updated

September 27, 2013

Status Verified

September 1, 2013

Enrollment Period

3.9 years

First QC Date

July 15, 2004

Last Update Submit

September 26, 2013

Conditions

AtherosclerosisCardiovascular DiseasesHeart DiseasesCoronary ArteriosclerosisCoronary DiseaseCerebral ArteriosclerosisCerebrovascular Accident

Outcome Measures

Primary Outcomes (1)

  • T helper bias

    T helper bias is a stable phenotype in people, with few environmental drives; the main environmental driver appears to be anti-CMV titer; this has led to our view that genetics probably plays a role, and our current GWAS efforts using our unique MESA-Inflammation cellular phenotypes.

    2008

Secondary Outcomes (1)

  • T helper bias toward Th1 cells

    2008

Other Outcomes (1)

  • atherosclerosis

    2008

Eligibility Criteria

Age45 Years - 84 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

1,000 men and women aged 45-84 years

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

MeSH Terms

Conditions

AtherosclerosisCardiovascular DiseasesHeart DiseasesCoronary Artery DiseaseCoronary DiseaseIntracranial ArteriosclerosisStroke

Condition Hierarchy (Ancestors)

ArteriosclerosisArterial Occlusive DiseasesVascular DiseasesMyocardial IschemiaIntracranial Arterial DiseasesCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System Diseases

Study Officials

  • Russell Tracy

    University of Vermont

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor of Pathology

Study Record Dates

First Submitted

July 15, 2004

First Posted

July 19, 2004

Study Start

July 1, 2004

Primary Completion

June 1, 2008

Study Completion

June 1, 2008

Last Updated

September 27, 2013

Record last verified: 2013-09