NCT00091754

Brief Summary

To identify new cellular, metabolic, and genomic correlates of atherosclerotic plaque and early pathologic changes in the vascular wall and determine their consequences for coronary heart disease and stroke.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Sep 2004

Typical duration for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2004

Completed
15 days until next milestone

First Submitted

Initial submission to the registry

September 16, 2004

Completed
4 days until next milestone

First Posted

Study publicly available on registry

September 20, 2004

Completed
3.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2008

Completed
Last Updated

October 1, 2021

Status Verified

September 1, 2021

Enrollment Period

3.8 years

First QC Date

September 16, 2004

Last Update Submit

September 29, 2021

Conditions

AtherosclerosisCardiovascular DiseasesHeart DiseasesCerebrovascular AccidentCoronary ArteriosclerosisCoronary Disease

Eligibility Criteria

Age45 Years - 64 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)
Sampling MethodProbability Sample
Study Population

The current study collects new and novel risk factors and performs carotid magnetic resonance imaging (MRI) examinations on a stratified random sample of 1,200 ARIC participants with high (\>85th percentile) carotid intimal-medial thickness \[IMT\] by ultrasound and 800 participants with \<85th percentile IMT.

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Biospecimen

Retention: SAMPLES WITH DNA

Stored DNA in Atherosclerosis Risk in Communities (ARIC) cohort study to test the ability of the genomic correlates of plaque characteristics to predict incident coronary heart disease and stroke.

MeSH Terms

Conditions

AtherosclerosisCardiovascular DiseasesHeart DiseasesStrokeCoronary Artery DiseaseCoronary Disease

Condition Hierarchy (Ancestors)

ArteriosclerosisArterial Occlusive DiseasesVascular DiseasesCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesMyocardial Ischemia

Study Officials

  • Eric Boerwinkle, Ph.D

    University of Texas

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
OTHER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor - School of Public Health

Study Record Dates

First Submitted

September 16, 2004

First Posted

September 20, 2004

Study Start

September 1, 2004

Primary Completion

June 1, 2008

Study Completion

June 1, 2008

Last Updated

October 1, 2021

Record last verified: 2021-09