NCT00005349

Brief Summary

Using subjects from the Rochester Family Heart Study (RFHS), to characterize predictors of coronary artery calcification (CAC), a potent marker of atherosclerosis, among individuals from the general population.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,736

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Apr 1991

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 1991

Completed
9.2 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
7.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2008

Completed
Last Updated

June 19, 2013

Status Verified

June 1, 2013

Enrollment Period

16.8 years

First QC Date

May 25, 2000

Last Update Submit

June 18, 2013

Conditions

Cardiovascular DiseasesAtherosclerosisCoronary ArteriosclerosisHeart DiseasesCoronary Disease

Outcome Measures

Primary Outcomes (1)

  • Coronary Artery Calcification

    1991-2005

Secondary Outcomes (1)

  • Coronary disease risk factors

    1991-2005

Other Outcomes (1)

  • coronary artery disease risk factors

    1991-2005

Eligibility Criteria

Age20 Years - 91 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

817 men and 830 women ages 20 and older recruited from Rochester, MN.

Individuals were recruited to participate if they had participated in the Rochester Family Heart Study or were siblings of those already in the ECAC study or had been in the GENOA Study or were identified to be at higher risk for having CAC. Potential participants were eligible if they were not pregnant, not lactating, and had never had coronary or non-coronary heart surgery. Eligibility for inclusion was independent of race, ethnicity, and country of birth.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (36)

  • Bielak LF, Kaufmann RB, Moll PP, McCollough CH, Schwartz RS, Sheedy PF 2nd. Small lesions in the heart identified at electron beam CT: calcification or noise? Radiology. 1994 Sep;192(3):631-6. doi: 10.1148/radiology.192.3.8058926.

    PMID: 8058926BACKGROUND

  • Blanco-Vaca F, Gaubatz JW, Bren N, Kottke BA, Morrisett JD, Guevara J Jr. Identification and quantification of apolipoproteins in addition to apo[a] and apo B-100 in human lipoprotein[a]. Chem Phys Lipids. 1994 Jan;67-68:35-42. doi: 10.1016/0009-3084(94)90122-8.

    PMID: 8187234BACKGROUND

  • Rastogi A, Bren ND, Hallaway BJ, Kottke BA. Immunomagnetic separation of subpopulations of apolipoprotein A-I. Mayo Clin Proc. 1994 Feb;69(2):137-43. doi: 10.1016/s0025-6196(12)61040-4.

    PMID: 8309265BACKGROUND

  • Kaufmann RB, Sheedy PF 2nd, Breen JF, Kelzenberg JR, Kruger BL, Schwartz RS, Moll PP. Detection of heart calcification with electron beam CT: interobserver and intraobserver reliability for scoring quantification. Radiology. 1994 Feb;190(2):347-52. doi: 10.1148/radiology.190.2.8284380.

    PMID: 8284380BACKGROUND

  • Kanaley JA, Andresen-Reid ML, Oenning L, Kottke BA, Jensen MD. Differential health benefits of weight loss in upper-body and lower-body obese women. Am J Clin Nutr. 1993 Jan;57(1):20-6. doi: 10.1093/ajcn/57.1.20.

    PMID: 8416660BACKGROUND

  • Peyser PA. Genetic epidemiology of coronary artery disease. Epidemiol Rev. 1997;19(1):80-90. doi: 10.1093/oxfordjournals.epirev.a017949. No abstract available.

    PMID: 9360905BACKGROUND

  • Rumberger JA, Sheedy PF, Breen JF, Schwartz RS. Electron beam computed tomographic coronary calcium score cutpoints and severity of associated angiographic lumen stenosis. J Am Coll Cardiol. 1997 Jun;29(7):1542-8. doi: 10.1016/s0735-1097(97)00093-4.

    PMID: 9180117BACKGROUND

  • Rumberger JA, Sheedy PF 2nd, Breen JF, Fitzpatrick LA, Schwartz RS. Electron beam computed tomography and coronary artery disease: scanning for coronary artery calcification. Mayo Clin Proc. 1996 Apr;71(4):369-77. doi: 10.4065/71.4.369.

    PMID: 8637260BACKGROUND

  • Rumberger JA, Simons DB, Fitzpatrick LA, Sheedy PF, Schwartz RS. Coronary artery calcium area by electron-beam computed tomography and coronary atherosclerotic plaque area. A histopathologic correlative study. Circulation. 1995 Oct 15;92(8):2157-62. doi: 10.1161/01.cir.92.8.2157.

    PMID: 7554196BACKGROUND

  • McCollough CH, Kaufmann RB, Cameron BM, Katz DJ, Sheedy PF 2nd, Peyser PA. Electron-beam CT: use of a calibration phantom to reduce variability in calcium quantitation. Radiology. 1995 Jul;196(1):159-65. doi: 10.1148/radiology.196.1.7784560.

    PMID: 7784560BACKGROUND

  • Rumberger JA, Sheedy PF 3rd, Breen JF, Schwartz RS. Coronary calcium, as determined by electron beam computed tomography, and coronary disease on arteriogram. Effect of patient's sex on diagnosis. Circulation. 1995 Mar 1;91(5):1363-7. doi: 10.1161/01.cir.91.5.1363.

    PMID: 7867174BACKGROUND

  • Kaufmann RB, Sheedy PF 2nd, Maher JE, Bielak LF, Breen JF, Schwartz RS, Peyser PA. Quantity of coronary artery calcium detected by electron beam computed tomography in asymptomatic subjects and angiographically studied patients. Mayo Clin Proc. 1995 Mar;70(3):223-32. doi: 10.4065/70.3.223.

    PMID: 7861809BACKGROUND

  • Kaufmann RB, Peyser PA, Sheedy PF, Rumberger JA, Schwartz RS. Quantification of coronary artery calcium by electron beam computed tomography for determination of severity of angiographic coronary artery disease in younger patients. J Am Coll Cardiol. 1995 Mar 1;25(3):626-32. doi: 10.1016/0735-1097(94)00435-S.

    PMID: 7860906BACKGROUND

  • Maher JE, Raz JA, Bielak LF, Sheedy PF 2nd, Schwartz RS, Peyser PA. Potential of quantity of coronary artery calcification to identify new risk factors for asymptomatic atherosclerosis. Am J Epidemiol. 1996 Nov 15;144(10):943-53. doi: 10.1093/oxfordjournals.aje.a008864.

    PMID: 8916505BACKGROUND

  • Kardia SL, Haviland MB, Ferrell RE, Sing CF. The relationship between risk factor levels and presence of coronary artery calcification is dependent on apolipoprotein E genotype. Arterioscler Thromb Vasc Biol. 1999 Feb;19(2):427-35. doi: 10.1161/01.atv.19.2.427.

    PMID: 9974428BACKGROUND

  • Maher JE, Bielak LF, Raz JA, Sheedy PF 2nd, Schwartz RS, Peyser PA. Progression of coronary artery calcification: a pilot study. Mayo Clin Proc. 1999 Apr;74(4):347-55. doi: 10.4065/74.4.347.

    PMID: 10221462BACKGROUND

  • Rumberger JA, Behrenbeck T, Breen JF, Sheedy PF 2nd. Coronary calcification by electron beam computed tomography and obstructive coronary artery disease: a model for costs and effectiveness of diagnosis as compared with conventional cardiac testing methods. J Am Coll Cardiol. 1999 Feb;33(2):453-62. doi: 10.1016/s0735-1097(98)00583-x.

    PMID: 9973026BACKGROUND

  • Bielak LF, Sheedy PF 2nd, Peyser PA. Coronary artery calcification measured at electron-beam CT: agreement in dual scan runs and change over time. Radiology. 2001 Jan;218(1):224-9. doi: 10.1148/radiology.218.1.r01ja34224.

    PMID: 11152806BACKGROUND

  • Bielak LF, Klee GG, Sheedy PF 2nd, Turner ST, Schwartz RS, Peyser PA. Association of fibrinogen with quantity of coronary artery calcification measured by electron beam computed tomography. Arterioscler Thromb Vasc Biol. 2000 Sep;20(9):2167-71. doi: 10.1161/01.atv.20.9.2167.

    PMID: 10978265BACKGROUND

  • Bielak LF, Rumberger JA, Sheedy PF 2nd, Schwartz RS, Peyser PA. Probabilistic model for prediction of angiographically defined obstructive coronary artery disease using electron beam computed tomography calcium score strata. Circulation. 2000 Jul 25;102(4):380-5. doi: 10.1161/01.cir.102.4.380.

    PMID: 10908208BACKGROUND

  • Lange LA, Lange EM, Bielak LF, Langefeld CD, Kardia SL, Royston P, Turner ST, Sheedy PF 2nd, Boerwinkle E, Peyser PA. Autosomal genome-wide scan for coronary artery calcification loci in sibships at high risk for hypertension. Arterioscler Thromb Vasc Biol. 2002 Mar 1;22(3):418-23. doi: 10.1161/hq0302.105721.

    PMID: 11884284BACKGROUND

  • Ellsworth DL, Bielak LF, Turner ST, Sheedy PF 2nd, Boerwinkle E, Peyser PA. Gender- and age-dependent relationships between the E-selectin S128R polymorphism and coronary artery calcification. J Mol Med (Berl). 2001 Jul;79(7):390-8. doi: 10.1007/s001090100235.

    PMID: 11466561BACKGROUND

  • Turner ST, Bielak LF, Narayana AK, Sheedy PF 2nd, Schwartz GL, Peyser PA. Ambulatory blood pressure and coronary artery calcification in middle-aged and younger adults. Am J Hypertens. 2002 Jun;15(6):518-24. doi: 10.1016/s0895-7061(02)02271-9.

    PMID: 12074353BACKGROUND

  • Peyser PA, Bielak LF, Chu JS, Turner ST, Ellsworth DL, Boerwinkle E, Sheedy PF 2nd. Heritability of coronary artery calcium quantity measured by electron beam computed tomography in asymptomatic adults. Circulation. 2002 Jul 16;106(3):304-8. doi: 10.1161/01.cir.0000022664.21832.5d.

    PMID: 12119244BACKGROUND

  • Bielak LF, Peyser PA, Sheedy PF 2nd. Electron-beam computed tomography screening for asymptomatic coronary artery disease. Semin Roentgenol. 2003 Jan;38(1):39-53. doi: 10.1016/s0037-198x(03)00008-7. No abstract available.

    PMID: 12698590BACKGROUND

  • Jamjoum LS, Bielak LF, Turner ST, Sheedy II PF, Boerwinkle E, Raghunathan TE, Peyser PA. Relationship of blood pressure measures with coronary artery calcification. Med Sci Monit. 2002 Dec;8(12):CR775-81.

    PMID: 12503034BACKGROUND

  • Kullo IJ, McConnell JP, Bailey KR, Kardia SL, Bielak LF, Peyser PA, Sheedy PF 2nd, Boerwinkle E, Turner ST. Relation of C-reactive protein and fibrinogen to coronary artery calcium in subjects with systemic hypertension. Am J Cardiol. 2003 Jul 1;92(1):56-8. doi: 10.1016/s0002-9149(03)00466-1. No abstract available.

    PMID: 12842247BACKGROUND

  • Christian RC, Dumesic DA, Behrenbeck T, Oberg AL, Sheedy PF 2nd, Fitzpatrick LA. Prevalence and predictors of coronary artery calcification in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2003 Jun;88(6):2562-8. doi: 10.1210/jc.2003-030334.

    PMID: 12788855BACKGROUND

  • Kardia SL, Modell SM, Peyser PA. Family-centered approaches to understanding and preventing coronary heart disease. Am J Prev Med. 2003 Feb;24(2):143-51. doi: 10.1016/s0749-3797(02)00587-1.

    PMID: 12568820BACKGROUND

  • Keelan PC, Bielak LF, Ashai K, Jamjoum LS, Denktas AE, Rumberger JA, Sheedy II PF, Peyser PA, Schwartz RS. Long-term prognostic value of coronary calcification detected by electron-beam computed tomography in patients undergoing coronary angiography. Circulation. 2001 Jul 24;104(4):412-7. doi: 10.1161/hc2901.093112.

    PMID: 11468202BACKGROUND

  • Nallamothu BK, Saint S, Bielak LF, Sonnad SS, Peyser PA, Rubenfire M, Fendrick AM. Electron-beam computed tomography in the diagnosis of coronary artery disease: a meta-analysis. Arch Intern Med. 2001 Mar 26;161(6):833-8. doi: 10.1001/archinte.161.6.833.

    PMID: 11268225BACKGROUND

  • Messika-Zeitoun D, Aubry MC, Detaint D, Bielak LF, Peyser PA, Sheedy PF, Turner ST, Breen JF, Scott C, Tajik AJ, Enriquez-Sarano M. Evaluation and clinical implications of aortic valve calcification measured by electron-beam computed tomography. Circulation. 2004 Jul 20;110(3):356-62. doi: 10.1161/01.CIR.0000135469.82545.D0. Epub 2004 Jul 12.

    PMID: 15249504BACKGROUND

  • Bielak LF, Turner ST, Franklin SS, Sheedy PF 2nd, Peyser PA. Age-dependent associations between blood pressure and coronary artery calcification in asymptomatic adults. J Hypertens. 2004 Apr;22(4):719-25. doi: 10.1097/00004872-200404000-00014.

    PMID: 15126913BACKGROUND

  • Kullo IJ, Cassidy AE, Peyser PA, Turner ST, Sheedy PF 2nd, Bielak LF. Association between metabolic syndrome and subclinical coronary atherosclerosis in asymptomatic adults. Am J Cardiol. 2004 Dec 15;94(12):1554-8. doi: 10.1016/j.amjcard.2004.08.038.

    PMID: 15589016BACKGROUND

  • Cassidy AE, Bielak LF, Kullo IJ, Klee GG, Turner ST, Sheedy PF 2nd, Peyser PA. Sex-specific associations of lipoprotein(a) with presence and quantity of coronary artery calcification in an asymptomatic population. Med Sci Monit. 2004 Sep;10(9):CR493-503. Epub 2004 Aug 20.

    PMID: 15328481BACKGROUND

  • Cassidy AE, Bielak LF, Zhou Y, Sheedy PF 2nd, Turner ST, Breen JF, Araoz PA, Kullo IJ, Lin X, Peyser PA. Progression of subclinical coronary atherosclerosis: does obesity make a difference? Circulation. 2005 Apr 19;111(15):1877-82. doi: 10.1161/01.CIR.0000161820.40494.5D.

    PMID: 15837939BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesAtherosclerosisCoronary Artery DiseaseHeart DiseasesCoronary Disease

Condition Hierarchy (Ancestors)

ArteriosclerosisArterial Occlusive DiseasesVascular DiseasesMyocardial Ischemia

Study Officials

  • Patricia A Peyser, PhD

    University of Michigan

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
ECOLOGIC OR COMMUNITY
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

April 1, 1991

Primary Completion

February 1, 2008

Study Completion

February 1, 2008

Last Updated

June 19, 2013

Record last verified: 2013-06