NCT00005349|Completed
Epidemiology of Coronary Artery Calcification
ECAC
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ECAC
Sponsor study identifier
Secondary identifiers
observational
1,736
0 countries
N/A
Study Start
April 1991
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
February 2008
Actual (reported)Study Completion
February 2008
Actual (reported)Using subjects from the Rochester Family Heart Study (RFHS), to characterize predictors of coronary artery calcification (CAC), a potent marker of atherosclerosis, among individuals from the general population.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 2008
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 1991
Date type not reportedThis date has not been verified as actual or estimated.
May 25, 2000
Actual (reported)May 26, 2000
Actual (reported)February 2008
Actual (reported)February 2008
Actual (reported)Coronary Artery Calcification
1991-2005
Coronary disease risk factors
1991-2005
coronary artery disease risk factors
1991-2005
817 men and 830 women ages 20 and older recruited from Rochester, MN.
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Bielak LF, Kaufmann RB, Moll PP, McCollough CH, Schwartz RS, Sheedy PF 2nd. Small lesions in the heart identified at electron beam CT: calcification or noise? Radiology. 1994 Sep;192(3):631-6. doi: 10.1148/radiology.192.3.8058926.
Blanco-Vaca F, Gaubatz JW, Bren N, Kottke BA, Morrisett JD, Guevara J Jr. Identification and quantification of apolipoproteins in addition to apo[a] and apo B-100 in human lipoprotein[a]. Chem Phys Lipids. 1994 Jan;67-68:35-42. doi: 10.1016/0009-3084(94)90122-8.
Patricia A Peyser, PhD
University of Michigan
1,736 participants (actual enrollment reported by the registry).
First Submitted
May 25, 2000
First Posted
May 26, 2000
Study Start
April 1991
Date type not reportedThis date has not been verified as actual or estimated.
Rastogi A, Bren ND, Hallaway BJ, Kottke BA. Immunomagnetic separation of subpopulations of apolipoprotein A-I. Mayo Clin Proc. 1994 Feb;69(2):137-43. doi: 10.1016/s0025-6196(12)61040-4.
Kaufmann RB, Sheedy PF 2nd, Breen JF, Kelzenberg JR, Kruger BL, Schwartz RS, Moll PP. Detection of heart calcification with electron beam CT: interobserver and intraobserver reliability for scoring quantification. Radiology. 1994 Feb;190(2):347-52. doi: 10.1148/radiology.190.2.8284380.
Kanaley JA, Andresen-Reid ML, Oenning L, Kottke BA, Jensen MD. Differential health benefits of weight loss in upper-body and lower-body obese women. Am J Clin Nutr. 1993 Jan;57(1):20-6. doi: 10.1093/ajcn/57.1.20.
Peyser PA. Genetic epidemiology of coronary artery disease. Epidemiol Rev. 1997;19(1):80-90. doi: 10.1093/oxfordjournals.epirev.a017949. No abstract available.
Rumberger JA, Sheedy PF, Breen JF, Schwartz RS. Electron beam computed tomographic coronary calcium score cutpoints and severity of associated angiographic lumen stenosis. J Am Coll Cardiol. 1997 Jun;29(7):1542-8. doi: 10.1016/s0735-1097(97)00093-4.
Rumberger JA, Sheedy PF 2nd, Breen JF, Fitzpatrick LA, Schwartz RS. Electron beam computed tomography and coronary artery disease: scanning for coronary artery calcification. Mayo Clin Proc. 1996 Apr;71(4):369-77. doi: 10.4065/71.4.369.
Rumberger JA, Simons DB, Fitzpatrick LA, Sheedy PF, Schwartz RS. Coronary artery calcium area by electron-beam computed tomography and coronary atherosclerotic plaque area. A histopathologic correlative study. Circulation. 1995 Oct 15;92(8):2157-62. doi: 10.1161/01.cir.92.8.2157.
McCollough CH, Kaufmann RB, Cameron BM, Katz DJ, Sheedy PF 2nd, Peyser PA. Electron-beam CT: use of a calibration phantom to reduce variability in calcium quantitation. Radiology. 1995 Jul;196(1):159-65. doi: 10.1148/radiology.196.1.7784560.
Rumberger JA, Sheedy PF 3rd, Breen JF, Schwartz RS. Coronary calcium, as determined by electron beam computed tomography, and coronary disease on arteriogram. Effect of patient's sex on diagnosis. Circulation. 1995 Mar 1;91(5):1363-7. doi: 10.1161/01.cir.91.5.1363.
Kaufmann RB, Sheedy PF 2nd, Maher JE, Bielak LF, Breen JF, Schwartz RS, Peyser PA. Quantity of coronary artery calcium detected by electron beam computed tomography in asymptomatic subjects and angiographically studied patients. Mayo Clin Proc. 1995 Mar;70(3):223-32. doi: 10.4065/70.3.223.
Kaufmann RB, Peyser PA, Sheedy PF, Rumberger JA, Schwartz RS. Quantification of coronary artery calcium by electron beam computed tomography for determination of severity of angiographic coronary artery disease in younger patients. J Am Coll Cardiol. 1995 Mar 1;25(3):626-32. doi: 10.1016/0735-1097(94)00435-S.
Maher JE, Raz JA, Bielak LF, Sheedy PF 2nd, Schwartz RS, Peyser PA. Potential of quantity of coronary artery calcification to identify new risk factors for asymptomatic atherosclerosis. Am J Epidemiol. 1996 Nov 15;144(10):943-53. doi: 10.1093/oxfordjournals.aje.a008864.
Kardia SL, Haviland MB, Ferrell RE, Sing CF. The relationship between risk factor levels and presence of coronary artery calcification is dependent on apolipoprotein E genotype. Arterioscler Thromb Vasc Biol. 1999 Feb;19(2):427-35. doi: 10.1161/01.atv.19.2.427.
Maher JE, Bielak LF, Raz JA, Sheedy PF 2nd, Schwartz RS, Peyser PA. Progression of coronary artery calcification: a pilot study. Mayo Clin Proc. 1999 Apr;74(4):347-55. doi: 10.4065/74.4.347.
Rumberger JA, Behrenbeck T, Breen JF, Sheedy PF 2nd. Coronary calcification by electron beam computed tomography and obstructive coronary artery disease: a model for costs and effectiveness of diagnosis as compared with conventional cardiac testing methods. J Am Coll Cardiol. 1999 Feb;33(2):453-62. doi: 10.1016/s0735-1097(98)00583-x.
Bielak LF, Sheedy PF 2nd, Peyser PA. Coronary artery calcification measured at electron-beam CT: agreement in dual scan runs and change over time. Radiology. 2001 Jan;218(1):224-9. doi: 10.1148/radiology.218.1.r01ja34224.
Bielak LF, Klee GG, Sheedy PF 2nd, Turner ST, Schwartz RS, Peyser PA. Association of fibrinogen with quantity of coronary artery calcification measured by electron beam computed tomography. Arterioscler Thromb Vasc Biol. 2000 Sep;20(9):2167-71. doi: 10.1161/01.atv.20.9.2167.
Bielak LF, Rumberger JA, Sheedy PF 2nd, Schwartz RS, Peyser PA. Probabilistic model for prediction of angiographically defined obstructive coronary artery disease using electron beam computed tomography calcium score strata. Circulation. 2000 Jul 25;102(4):380-5. doi: 10.1161/01.cir.102.4.380.
Lange LA, Lange EM, Bielak LF, Langefeld CD, Kardia SL, Royston P, Turner ST, Sheedy PF 2nd, Boerwinkle E, Peyser PA. Autosomal genome-wide scan for coronary artery calcification loci in sibships at high risk for hypertension. Arterioscler Thromb Vasc Biol. 2002 Mar 1;22(3):418-23. doi: 10.1161/hq0302.105721.
Ellsworth DL, Bielak LF, Turner ST, Sheedy PF 2nd, Boerwinkle E, Peyser PA. Gender- and age-dependent relationships between the E-selectin S128R polymorphism and coronary artery calcification. J Mol Med (Berl). 2001 Jul;79(7):390-8. doi: 10.1007/s001090100235.
Turner ST, Bielak LF, Narayana AK, Sheedy PF 2nd, Schwartz GL, Peyser PA. Ambulatory blood pressure and coronary artery calcification in middle-aged and younger adults. Am J Hypertens. 2002 Jun;15(6):518-24. doi: 10.1016/s0895-7061(02)02271-9.
Peyser PA, Bielak LF, Chu JS, Turner ST, Ellsworth DL, Boerwinkle E, Sheedy PF 2nd. Heritability of coronary artery calcium quantity measured by electron beam computed tomography in asymptomatic adults. Circulation. 2002 Jul 16;106(3):304-8. doi: 10.1161/01.cir.0000022664.21832.5d.
Bielak LF, Peyser PA, Sheedy PF 2nd. Electron-beam computed tomography screening for asymptomatic coronary artery disease. Semin Roentgenol. 2003 Jan;38(1):39-53. doi: 10.1016/s0037-198x(03)00008-7. No abstract available.
Jamjoum LS, Bielak LF, Turner ST, Sheedy II PF, Boerwinkle E, Raghunathan TE, Peyser PA. Relationship of blood pressure measures with coronary artery calcification. Med Sci Monit. 2002 Dec;8(12):CR775-81.
Kullo IJ, McConnell JP, Bailey KR, Kardia SL, Bielak LF, Peyser PA, Sheedy PF 2nd, Boerwinkle E, Turner ST. Relation of C-reactive protein and fibrinogen to coronary artery calcium in subjects with systemic hypertension. Am J Cardiol. 2003 Jul 1;92(1):56-8. doi: 10.1016/s0002-9149(03)00466-1. No abstract available.
Christian RC, Dumesic DA, Behrenbeck T, Oberg AL, Sheedy PF 2nd, Fitzpatrick LA. Prevalence and predictors of coronary artery calcification in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2003 Jun;88(6):2562-8. doi: 10.1210/jc.2003-030334.
Kardia SL, Modell SM, Peyser PA. Family-centered approaches to understanding and preventing coronary heart disease. Am J Prev Med. 2003 Feb;24(2):143-51. doi: 10.1016/s0749-3797(02)00587-1.
Keelan PC, Bielak LF, Ashai K, Jamjoum LS, Denktas AE, Rumberger JA, Sheedy II PF, Peyser PA, Schwartz RS. Long-term prognostic value of coronary calcification detected by electron-beam computed tomography in patients undergoing coronary angiography. Circulation. 2001 Jul 24;104(4):412-7. doi: 10.1161/hc2901.093112.
Nallamothu BK, Saint S, Bielak LF, Sonnad SS, Peyser PA, Rubenfire M, Fendrick AM. Electron-beam computed tomography in the diagnosis of coronary artery disease: a meta-analysis. Arch Intern Med. 2001 Mar 26;161(6):833-8. doi: 10.1001/archinte.161.6.833.
Messika-Zeitoun D, Aubry MC, Detaint D, Bielak LF, Peyser PA, Sheedy PF, Turner ST, Breen JF, Scott C, Tajik AJ, Enriquez-Sarano M. Evaluation and clinical implications of aortic valve calcification measured by electron-beam computed tomography. Circulation. 2004 Jul 20;110(3):356-62. doi: 10.1161/01.CIR.0000135469.82545.D0. Epub 2004 Jul 12.
Bielak LF, Turner ST, Franklin SS, Sheedy PF 2nd, Peyser PA. Age-dependent associations between blood pressure and coronary artery calcification in asymptomatic adults. J Hypertens. 2004 Apr;22(4):719-25. doi: 10.1097/00004872-200404000-00014.
Kullo IJ, Cassidy AE, Peyser PA, Turner ST, Sheedy PF 2nd, Bielak LF. Association between metabolic syndrome and subclinical coronary atherosclerosis in asymptomatic adults. Am J Cardiol. 2004 Dec 15;94(12):1554-8. doi: 10.1016/j.amjcard.2004.08.038.
Cassidy AE, Bielak LF, Kullo IJ, Klee GG, Turner ST, Sheedy PF 2nd, Peyser PA. Sex-specific associations of lipoprotein(a) with presence and quantity of coronary artery calcification in an asymptomatic population. Med Sci Monit. 2004 Sep;10(9):CR493-503. Epub 2004 Aug 20.
Cassidy AE, Bielak LF, Zhou Y, Sheedy PF 2nd, Turner ST, Breen JF, Araoz PA, Kullo IJ, Lin X, Peyser PA. Progression of subclinical coronary atherosclerosis: does obesity make a difference? Circulation. 2005 Apr 19;111(15):1877-82. doi: 10.1161/01.CIR.0000161820.40494.5D.
Primary Completion
February 2008
Actual (reported)Study Completion
February 2008
Actual (reported)Last Updated
June 19, 2013
Record last verified: 2013-06
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