Family Heart Study - Subclinical Atherosclerosis Network (FHS-SCAN)
2 other identifiers
observational
3,389
0 countries
N/A
Brief Summary
To determine familial and non-familial causes for susceptibility to atherosclerosis and the inflammatory response.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2001
Longer than P75 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2001
CompletedFirst Submitted
Initial submission to the registry
September 21, 2001
CompletedFirst Posted
Study publicly available on registry
September 21, 2001
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2006
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2006
CompletedDecember 22, 2015
December 1, 2015
4.9 years
September 21, 2001
December 21, 2015
Conditions
Study Arms (2)
Caucasian Families
Largest 3-generational Caucasian Families from Family Heart Study (Classic) with average family size of 10 N=2767 Subjects from 512 families. Approximately half are random sample families from FamHS-Classic, and half are high-familial CHD risk families from FamHS-Classic. 4 Field sites were Raleigh-Durham North Carolina; Minneapolis, MN; Framingham MA; and Salt Lake City, UT.
African-American Families
622 subjects from 2-3 generational 212 African-American families originally recruited from the HyperGEN study in Birmingham AL. These are hypertension enriched families.
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
Related Publications (2)
Djousse L, Arnett DK, Carr JJ, Eckfeldt JH, Hopkins PN, Province MA, Ellison RC; Investigators of the NHLBI FHS. Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study. Circulation. 2005 Jun 7;111(22):2921-6. doi: 10.1161/CIRCULATIONAHA.104.489534. Epub 2005 May 31.
PMID: 15927976BACKGROUNDEllison RC, Zhang Y, Wagenknecht LE, Eckfeldt JH, Hopkins PN, Pankow JS, Djousse L, Carr JJ. Relation of the metabolic syndrome to calcified atherosclerotic plaque in the coronary arteries and aorta. Am J Cardiol. 2005 May 15;95(10):1180-6. doi: 10.1016/j.amjcard.2005.01.046.
PMID: 15877990BACKGROUND
Biospecimen
Stored DNA, lymphoblasts
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
John Carr
Wake Forest University
John Eckfeldt
University of Minnesota
R. Ellison
Boston University
Gerardo Heiss
University of North Carolina
James Hixson
University of Texas
Steven Hunt
University of Utah
Cora Lewis
University of Alabama at Birmingham
James Pankow
University of Minnesota
Michael Province
Washington University School of Medicine
Lynne Wagenknecht
Wake Forest University
Study Design
- Study Type
- observational
- Observational Model
- FAMILY BASED
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Genetics and Biostatistics
Study Record Dates
First Submitted
September 21, 2001
First Posted
September 21, 2001
Study Start
September 1, 2001
Primary Completion
August 1, 2006
Study Completion
August 1, 2006
Last Updated
December 22, 2015
Record last verified: 2015-12