NCT00005679

Brief Summary

To conduct a multicenter prevalence survey for characterizing pathologically the extent of atherosclerosis in the aortas and coronary arteries of young persons dying from accidental causes, suicide, or homicide.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Jun 1985

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 1985

Completed
8.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 1993

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 1993

Completed
6.9 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
Last Updated

February 18, 2016

Status Verified

January 1, 2008

Enrollment Period

8.1 years

First QC Date

May 25, 2000

Last Update Submit

February 17, 2016

Conditions

Cardiovascular DiseasesAtherosclerosisHeart DiseasesCoronary DiseaseCoronary Arteriosclerosis

Eligibility Criteria

Age15 Years - 34 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (52)

  • Relationship of atherosclerosis in young men to serum lipoprotein cholesterol concentrations and smoking. A preliminary report from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. JAMA. 1990 Dec 19;264(23):3018-24. doi: 10.1001/jama.1990.03450230054029.

    PMID: 2243430BACKGROUND

  • Hixson JE, McMahan CA, McGill HC Jr, Strong JP. Apo B insertion/deletion polymorphisms are associated with atherosclerosis in young black but not young white males. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Arterioscler Thromb. 1992 Sep;12(9):1023-9. doi: 10.1161/01.atv.12.9.1023.

    PMID: 1525116BACKGROUND

  • Hixson JE. Apolipoprotein E polymorphisms affect atherosclerosis in young males. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Arterioscler Thromb. 1991 Sep-Oct;11(5):1237-44. doi: 10.1161/01.atv.11.5.1237.

    PMID: 1680392BACKGROUND

  • Wissler RW. Theories and new horizons in the pathogenesis of atherosclerosis and the mechanisms of clinical effects. Arch Pathol Lab Med. 1992 Dec;116(12):1281-91.

    PMID: 1456873BACKGROUND

  • Wissler RW. USA Multicenter Study of the pathobiology of atherosclerosis in youth. Ann N Y Acad Sci. 1991;623:26-39. doi: 10.1111/j.1749-6632.1991.tb43716.x. No abstract available.

    PMID: 2042833BACKGROUND

  • Wissler RW, Vesselinovitch D, Komatsu A. The contribution of studies of atherosclerotic lesions in young people to future research. Ann N Y Acad Sci. 1990;598:418-34. doi: 10.1111/j.1749-6632.1990.tb42313.x. No abstract available.

    PMID: 2248455BACKGROUND

  • Wissler RW, Vesselinovitch D. An update on the pathogenesis of atherosclerosis (principles of prevention, intervention, retardation, and regression). Hawaii Med J. 1990 Jul;49(7):237-40, 261.

    PMID: 2397997BACKGROUND

  • McGill HC Jr, Strong JP, Tracy RE, McMahan CA, Oalmann MC. Relation of a postmortem renal index of hypertension to atherosclerosis in youth. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Arterioscler Thromb Vasc Biol. 1995 Dec;15(12):2222-8. doi: 10.1161/01.atv.15.12.2222.

    PMID: 7489246BACKGROUND

  • Cornhill JF, Herderick EE, Vince DG. The clinical morphology of human atherosclerotic lesions. Lessons from the PDAY Study. Pathobiological Determinants of Atherosclerosis in Youth. Wien Klin Wochenschr. 1995;107(18):540-3.

    PMID: 7483640BACKGROUND

  • McGill HC Jr, McMahan CA, Malcom GT, Oalmann MC, Strong JP. Relation of glycohemoglobin and adiposity to atherosclerosis in youth. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Arterioscler Thromb Vasc Biol. 1995 Apr;15(4):431-40. doi: 10.1161/01.atv.15.4.431.

    PMID: 7749853BACKGROUND

  • Strong JP. Natural history and risk factors for early human atherogenesis. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Clin Chem. 1995 Jan;41(1):134-8.

    PMID: 7813067BACKGROUND

  • Wissler RW. New insights into the pathogenesis of atherosclerosis as revealed by PDAY. Pathobiological Determinants of Atherosclerosis in Youth. Atherosclerosis. 1994 Aug;108 Suppl:S3-20. doi: 10.1016/0021-9150(94)90149-x.

    PMID: 7802726BACKGROUND

  • Natural history of aortic and coronary atherosclerotic lesions in youth. Findings from the PDAY Study. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Arterioscler Thromb. 1993 Sep;13(9):1291-8. doi: 10.1161/01.atv.13.9.1291.

    PMID: 8364013BACKGROUND

  • Kuo CC, Grayston JT, Campbell LA, Goo YA, Wissler RW, Benditt EP. Chlamydia pneumoniae (TWAR) in coronary arteries of young adults (15-34 years old). Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6911-4. doi: 10.1073/pnas.92.15.6911.

    PMID: 7624342BACKGROUND

  • Miller EJ, Malcom GT, McMahan CA, Strong JP. Atherosclerosis in young white males: arterial collagen and cholesterol. Matrix. 1993 Jul;13(4):289-96. doi: 10.1016/s0934-8832(11)80024-7.

    PMID: 8412986BACKGROUND

  • Strong JP, Malcom GT, Oalmann MC. Environmental and genetic risk factors in early human atherogenesis: lessons from the PDAY study. Pathobiological Determinants of Atherosclerosis in Youth. Pathol Int. 1995 Jun;45(6):403-8. doi: 10.1111/j.1440-1827.1995.tb03476.x.

    PMID: 7581930BACKGROUND

  • Strong JP. Atherosclerotic lesions. Natural history, risk factors, and topography. Arch Pathol Lab Med. 1992 Dec;116(12):1268-75.

    PMID: 1456871BACKGROUND

  • Strong JP, Malcom GT, Newman WP 3rd, Oalmann MC. Early lesions of atherosclerosis in childhood and youth: natural history and risk factors. J Am Coll Nutr. 1992 Jun;11 Suppl:51S-54S. doi: 10.1080/07315724.1992.10737984.

    PMID: 1619200BACKGROUND

  • Scanlon CE, Berger B, Malcom G, Wissler RW. Evidence for more extensive deposits of epitopes of oxidized low density lipoprotein in aortas of young people with elevated serum thiocyanate levels. PDAY Research Group. Atherosclerosis. 1996 Mar;121(1):23-33. doi: 10.1016/0021-9150(95)05672-6.

    PMID: 8678921BACKGROUND

  • Botti TP, Amin H, Hiltscher L, Wissler RW. A comparison of the quantitation of macrophage foam cell populations and the extent of apolipoprotein E deposition in developing atherosclerotic lesions in young people: high and low serum thiocyanate groups as an indication of smoking. PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth. Atherosclerosis. 1996 Aug 2;124(2):191-202. doi: 10.1016/0021-9150(96)05825-x.

    PMID: 8830932BACKGROUND

  • Komatsu A, Sakurai I. A study of the development of atherosclerosis in childhood and young adults: risk factors and the prevention of progression in Japan and the USA. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Pathol Int. 1996 Aug;46(8):541-7. doi: 10.1111/j.1440-1827.1996.tb03652.x.

    PMID: 8893222BACKGROUND

  • Wissler RW, Group PD. Atheroarteritis: a combined immunological and lipid imbalance. Int J Cardiol. 1996 Aug;54 Suppl:S37-49. doi: 10.1016/s0167-5273(96)88772-9.

    PMID: 9119526BACKGROUND

  • Strong JP, Malcom GT, Oalmann MC, Wissler RW. The PDAY Study: natural history, risk factors, and pathobiology. Pathobiological Determinants of Atherosclerosis in Youth. Ann N Y Acad Sci. 1997 Apr 15;811:226-35; discussion 235-7. doi: 10.1111/j.1749-6632.1997.tb52004.x. No abstract available.

    PMID: 9186600BACKGROUND

  • Malcom GT, Oalmann MC, Strong JP. Risk factors for atherosclerosis in young subjects: the PDAY Study. Pathobiological Determinants of Atherosclerosis in Youth. Ann N Y Acad Sci. 1997 May 28;817:179-88. doi: 10.1111/j.1749-6632.1997.tb48205.x. No abstract available.

    PMID: 9239187BACKGROUND

  • Kuhn H, Heydeck D, Hugou I, Gniwotta C. In vivo action of 15-lipoxygenase in early stages of human atherogenesis. J Clin Invest. 1997 Mar 1;99(5):888-93. doi: 10.1172/JCI119253.

    PMID: 9062346BACKGROUND

  • McGill HC Jr, McMahan CA, Malcom GT, Oalmann MC, Strong JP. Effects of serum lipoproteins and smoking on atherosclerosis in young men and women. The PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth. Arterioscler Thromb Vasc Biol. 1997 Jan;17(1):95-106. doi: 10.1161/01.atv.17.1.95.

    PMID: 9012643BACKGROUND

  • Zieske AW, Takei H, Fallon KB, Strong JP. Smoking and atherosclerosis in youth. Atherosclerosis. 1999 Jun;144(2):403-8. doi: 10.1016/s0021-9150(98)00326-8.

    PMID: 10407501BACKGROUND

  • Rainwater DL, McMahan CA, Malcom GT, Scheer WD, Roheim PS, McGill HC Jr, Strong JP. Lipid and apolipoprotein predictors of atherosclerosis in youth: apolipoprotein concentrations do not materially improve prediction of arterial lesions in PDAY subjects. The PDAY Research Group. Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):753-61. doi: 10.1161/01.atv.19.3.753.

    PMID: 10073983BACKGROUND

  • McGill HC Jr, McMahan CA, Tracy RE, Oalmann MC, Cornhill JF, Herderick EE, Strong JP. Relation of a postmortem renal index of hypertension to atherosclerosis and coronary artery size in young men and women. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Arterioscler Thromb Vasc Biol. 1998 Jul;18(7):1108-18. doi: 10.1161/01.atv.18.7.1108.

    PMID: 9672071BACKGROUND

  • McGill HC Jr, McMahan CA. Determinants of atherosclerosis in the young. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Am J Cardiol. 1998 Nov 26;82(10B):30T-36T. doi: 10.1016/s0002-9149(98)00720-6.

    PMID: 9860371BACKGROUND

  • Wissler RW, Strong JP. Risk factors and progression of atherosclerosis in youth. PDAY Research Group. Pathological Determinants of Atherosclerosis in Youth. Am J Pathol. 1998 Oct;153(4):1023-33. doi: 10.1016/s0002-9440(10)65647-7. No abstract available.

    PMID: 9777934BACKGROUND

  • Strong JP, Malcom GT, McMahan CA, Tracy RE, Newman WP 3rd, Herderick EE, Cornhill JF. Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study. JAMA. 1999 Feb 24;281(8):727-35. doi: 10.1001/jama.281.8.727.

    PMID: 10052443BACKGROUND

  • Sloop GD, Perret RS, Brahney JS, Oalmann M. A description of two morphologic patterns of aortic fatty streaks, and a hypothesis of their pathogenesis. Atherosclerosis. 1998 Nov;141(1):153-60. doi: 10.1016/s0021-9150(98)00167-1.

    PMID: 9863548BACKGROUND

  • Wissler RW. An overview of the quantitative influence of several risk factors on progression of atherosclerosis in young people in the United States. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Am J Med Sci. 1995 Dec;310 Suppl 1:S29-36. doi: 10.1097/00000441-199512000-00006.

    PMID: 7503120BACKGROUND

  • McGill HC Jr, McMahan CA, Zieske AW, Tracy RE, Malcom GT, Herderick EE, Strong JP. Association of Coronary Heart Disease Risk Factors with microscopic qualities of coronary atherosclerosis in youth. Circulation. 2000 Jul 25;102(4):374-9. doi: 10.1161/01.cir.102.4.374.

    PMID: 10908207BACKGROUND

  • McGill HC Jr, McMahan CA, Herderick EE, Tracy RE, Malcom GT, Zieske AW, Strong JP. Effects of coronary heart disease risk factors on atherosclerosis of selected regions of the aorta and right coronary artery. PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth. Arterioscler Thromb Vasc Biol. 2000 Mar;20(3):836-45. doi: 10.1161/01.atv.20.3.836.

    PMID: 10712411BACKGROUND

  • Zieske AW, Malcom GT, Strong JP. Pathobiological determinants of atherosclerosis in youth (PDAY) cardiovascular specimen and data library. J La State Med Soc. 2000 Jun;152(6):296-301.

    PMID: 10935370BACKGROUND

  • McGill HC Jr, McMahan CA, Zieske AW, Malcom GT, Tracy RE, Strong JP. Effects of nonlipid risk factors on atherosclerosis in youth with a favorable lipoprotein profile. Circulation. 2001 Mar 20;103(11):1546-50. doi: 10.1161/01.cir.103.11.1546.

    PMID: 11257083BACKGROUND

  • McGill HC Jr, McMahan CA, Zieske AW, Sloop GD, Walcott JV, Troxclair DA, Malcom GT, Tracy RE, Oalmann MC, Strong JP. Associations of coronary heart disease risk factors with the intermediate lesion of atherosclerosis in youth. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Arterioscler Thromb Vasc Biol. 2000 Aug;20(8):1998-2004. doi: 10.1161/01.atv.20.8.1998.

    PMID: 10938023BACKGROUND

  • Rao RN, Falls DG, Gerrity RG, Sethuraman SN, Thiruvaiyaru DS. Intimal thickness and layering, and smooth muscle cell phenotypes in aorta of youth. Pathobiology. 2000 Jan-Feb;68(1):18-28. doi: 10.1159/000028111.

    PMID: 10859527BACKGROUND

  • Zieske AW, Malcom GT, Strong JP. Natural history and risk factors of atherosclerosis in children and youth: the PDAY study. Pediatr Pathol Mol Med. 2002 Mar-Apr;21(2):213-37. doi: 10.1080/15227950252852104.

    PMID: 11942537BACKGROUND

  • Millonig G, Malcom GT, Wick G. Early inflammatory-immunological lesions in juvenile atherosclerosis from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY)-study. Atherosclerosis. 2002 Feb;160(2):441-8. doi: 10.1016/s0021-9150(01)00596-2.

    PMID: 11849669BACKGROUND

  • Ishikawa Y, Ishii T, Akasaka Y, Masuda T, Strong JP, Zieske AW, Takei H, Malcom GT, Taniyama M, Choi-Miura NH, Tomita M. Immunolocalization of apolipoproteins in aortic atherosclerosis in American youths and young adults: findings from the PDAY study. Atherosclerosis. 2001 Sep;158(1):215-25. doi: 10.1016/s0021-9150(01)00416-6.

    PMID: 11500194BACKGROUND

  • Homma S, Ishii T, Malcom GT, Zieske AW, Strong JP, Tsugane S, Hirose N. Histopathological modifications of early atherosclerotic lesions by risk factors--findings in PDAY subjects. Atherosclerosis. 2001 Jun;156(2):389-99. doi: 10.1016/s0021-9150(00)00669-9.

    PMID: 11395036BACKGROUND

  • McGill HC Jr, McMahan CA, Herderick EE, Zieske AW, Malcom GT, Tracy RE, Strong JP; Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Obesity accelerates the progression of coronary atherosclerosis in young men. Circulation. 2002 Jun 11;105(23):2712-8. doi: 10.1161/01.cir.0000018121.67607.ce.

    PMID: 12057983BACKGROUND

  • McGill HC Jr, Herderick EE, McMahan CA, Zieske AW, Malcolm GT, Tracy RE, Strong JP. Atherosclerosis in youth. Minerva Pediatr. 2002 Oct;54(5):437-47.

    PMID: 12244281BACKGROUND

  • Strong JP, Zieske AW, Malcom GT. Lipoproteins and atherosclerosis in children: an early marriage? Nutr Metab Cardiovasc Dis. 2001 Oct;11 Suppl 5:16-22.

    PMID: 12063771BACKGROUND

  • Cohen HW, Sloop GD; PDAY Study. Glucose interaction magnifies atherosclerotic risk from cholesterol. Findings from the PDAY Study. Atherosclerosis. 2004 Jan;172(1):115-20. doi: 10.1016/j.atherosclerosis.2003.09.010.

    PMID: 14709364BACKGROUND

  • McMahan CA, Gidding SS, Fayad ZA, Zieske AW, Malcom GT, Tracy RE, Strong JP, McGill HC Jr. Risk scores predict atherosclerotic lesions in young people. Arch Intern Med. 2005 Apr 25;165(8):883-90. doi: 10.1001/archinte.165.8.883.

    PMID: 15851639BACKGROUND

  • Zieske AW, McMahan CA, McGill HC Jr, Homma S, Takei H, Malcom GT, Tracy RE, Strong JP. Smoking is associated with advanced coronary atherosclerosis in youth. Atherosclerosis. 2005 May;180(1):87-92. doi: 10.1016/j.atherosclerosis.2004.10.039. Epub 2004 Dec 15.

    PMID: 15823279BACKGROUND

  • Scheer WD, Boudreau DA, Hixson JE, McGill HC, Newman WP 3rd, Tracy RE, Zieske AW, Strong JP. ACE insert/delete polymorphism and atherosclerosis. Atherosclerosis. 2005 Feb;178(2):241-7. doi: 10.1016/j.atherosclerosis.2004.09.019.

    PMID: 15694930BACKGROUND

  • Wissler RW. Update on the pathogenesis of atherosclerosis. Am J Med. 1991 Jul 31;91(1B):3S-9S. doi: 10.1016/0002-9343(91)90050-8.

    PMID: 1867233BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesAtherosclerosisHeart DiseasesCoronary DiseaseCoronary Artery Disease

Condition Hierarchy (Ancestors)

ArteriosclerosisArterial Occlusive DiseasesVascular DiseasesMyocardial Ischemia

Study Officials

  • Arthur Chandler

    Augusta University

  • J. Cornhill

    Ohio State University

  • Asaad Daoud

    Albany Medical College

  • Morton Friedman

    Ohio State University

  • Steffen Gay

    University of Alabama at Birmingham

  • James Hixson

    Southwest Foundation for Biomedical Research

  • Singanallur Jagannathan

    West Virginia University Medical Center

  • C. McMahan

    University of Texas

  • Wolfgang Mergner

    University of Maryland

  • Edward Miller

    University of Alabama at Birmingham

  • Stanley Radio

    University of Nebraska

  • Dennis Reichebach

    University of Washington

  • Abel Robertson

    University of Illinois at Chicago

  • Louis Smith

    Baylor College of Medicine

  • Jack Strong

    Louisiana State University Medical Center

  • Renu Virmani

    Vanderbilt University School of Medicine

  • Robert Wissler

    University of Chicago

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

June 1, 1985

Primary Completion

July 1, 1993

Study Completion

July 1, 1993

Last Updated

February 18, 2016

Record last verified: 2008-01