S0124: Cisplatin Combined With Irinotecan or Etoposide For Extensive-Stage Small Cell Lung Cancer
Randomized Phase III Trial of Cisplatin and Irinotecan (NSC-616348) Versus Cisplatin and Etoposide in Patients With Extensive Stage Small Cell Lung Cancer (E-SCLC)
3 other identifiers
interventional
671
2 countries
408
Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known whether cisplatin combined with irinotecan is more effective than cisplatin combined with etoposide in treating extensive-stage small cell lung cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of cisplatin combined with either irinotecan or etoposide in treating patients who have extensive-stage small cell lung cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 lung-cancer
Started Nov 2002
Typical duration for phase_3 lung-cancer
408 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 6, 2002
CompletedStudy Start
First participant enrolled
November 1, 2002
CompletedFirst Posted
Study publicly available on registry
January 27, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2009
CompletedResults Posted
Study results publicly available
July 9, 2013
CompletedJuly 31, 2018
July 1, 2018
5.3 years
September 6, 2002
April 16, 2013
July 3, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Overall Survival
Overall survival was defined as the duration between the date of randomization( enrollment) and the date of death due to any cause. Patients last known to be alive were censored at the date of last contact.
Weekly while on treatment, then every 3 months for first year, then every 6 months unitl a maximum of 3 years from enrollment.
Secondary Outcomes (3)
Progression-free Survival
Every 6 weeks until disease progression or a maximum of 3 years from the date of enrollment.
Confirmed and Unconfirmed Complete and Partial Responses.
Every 6 weeks while on protocol treatment for a maximum of 12 weeks
Number of Patients With a Given Type and Grade of Adverse Event.
Every 4 weeks while subject on protocol treatment for a maximum of 12 weeks.
Study Arms (2)
1
ACTIVE COMPARATOR2
ACTIVE COMPARATORInterventions
Arm 1: 60 mg/m2 IV (over 30-60 min) on Day 1, Q 4 weeks x 4 Cycles Arm 2: 80 mg/m2 IV (over 30-60 min) on Day 1, Q 4 weeks x 4 Cycles
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
- SWOG Cancer Research Networklead
- National Cancer Institute (NCI)collaborator
- North Central Cancer Treatment Groupcollaborator
- Cancer and Leukemia Group Bcollaborator
Study Sites (408)
Northeast Alabama Regional Medical Center
Anniston, Alabama, 36202, United States
Huntsville Hospital
Huntsville, Alabama, 35801, United States
Mobile Infirmary Medical Center
Mobile, Alabama, 36652-2144, United States
East Alabama Medical Center
Opelika, Alabama, 36801-5452, United States
Alaska Regional Hospital Cancer Center
Anchorage, Alaska, 99508, United States
Mayo Clinic Scottsdale
Scottsdale, Arizona, 85259-5499, United States
Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson, Arizona, 85724-5024, United States
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
Fort Smith, Arkansas, 72903, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
Providence Saint Joseph Medical Center - Burbank
Burbank, California, 91505, United States
Cancer Care Center at John Muir Health - Concord Campus
Concord, California, 94524-4110, United States
Washington Township Hospital
Fremont, California, 94538, United States
California Cancer Center - Woodward Park Office
Fresno, California, 93720, United States
USC/Norris Comprehensive Cancer Center and Hospital
Los Angeles, California, 90089-9181, United States
Desert Regional Medical Center Comprehensive Cancer Center
Palm Springs, California, 92262, United States
Shasta Regional Medical Center
Redding, California, 96001, United States
Sutter Cancer Center at Roseville Medical Center
Roseville, California, 95661, United States
Sutter Cancer Center
Sacramento, California, 95816, United States
University of California Davis Cancer Center
Sacramento, California, 95817, United States
CCOP - Santa Rosa Memorial Hospital
Santa Rosa, California, 95405, United States
John Muir/Mt. Diablo Comprehensive Cancer Center
Walnut Creek, California, 94598, United States
Memorial Hospital
Colorado Springs, Colorado, 80909, United States
Eastern Connecticut Hematology and Oncology Associates
Norwich, Connecticut, 06360, United States
Halifax Medical Center - Daytona Beach
Daytona Beach, Florida, 32115, United States
Broward General Medical Center Cancer Center
Fort Lauderdale, Florida, 33316, United States
West Florida Cancer Institute at West Florida Hospital - Pensacola
Pensacola, Florida, 32514, United States
Piedmont Hospital
Atlanta, Georgia, 30309, United States
Northside Hospital Cancer Center
Atlanta, Georgia, 30342-1611, United States
Saint Joseph's Hospital of Atlanta
Atlanta, Georgia, 30342-1701, United States
CCOP - Atlanta Regional
Atlanta, Georgia, 30342, United States
Augusta Oncology Associates - Walton Way
Augusta, Georgia, 30901, United States
WellStar Cobb Hospital
Austell, Georgia, 30106, United States
Charles B. Eberhart Cancer Center at DeKalb Medical Center
Decatur, Georgia, 30033, United States
Gwinnett Medical Center
Lawrenceville, Georgia, 30045, United States
Kennestone Cancer Center at Wellstar Kennestone Hospital
Marietta, Georgia, 30060, United States
Southern Regional Medical Center
Riverdale, Georgia, 30274-2600, United States
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
Savannah, Georgia, 31403-3089, United States
Pearlman Comprehensive Cancer Center at South Georgia Medical Center
Valdosta, Georgia, 31603, United States
Tripler Army Medical Center
Honolulu, Hawaii, 96859, United States
Hematology Oncology Associates of Eastern Idaho
Idaho Falls, Idaho, 83404, United States
Saint Anthony's Hospital at Saint Anthony's Health Center
Alton, Illinois, 62002, United States
Rush-Copley Cancer Care Center
Aurora, Illinois, 60507, United States
Decatur Memorial Hospital Cancer Care Institute
Decatur, Illinois, 62526, United States
Elmhurst Memorial Hospital
Elmhurst, Illinois, 60126, United States
Veterans Affairs Medical Center - Hines
Hines, Illinois, 60141, United States
Joliet Oncology-Hematology Associates, Limited - West
Joliet, Illinois, 60435, United States
La Grange Memorial Hospital
La Grange, Illinois, 60525, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center
Maywood, Illinois, 60153, United States
Trinity Medical Center - East
Moline, Illinois, 61265, United States
Unknown Facility
Moline, Illinois, 61265, United States
Good Samaritan Regional Health Center
Mount Vernon, Illinois, 62864, United States
West Suburban Center for Cancer Care
River Forest, Illinois, 60305, United States
Swedish-American Regional Cancer Center
Rockford, Illinois, 61104-2315, United States
Regional Cancer Center at Memorial Medical Center
Springfield, Illinois, 62781-0001, United States
Carle Cancer Center at Carle Foundation Hospital
Urbana, Illinois, 61801, United States
CCOP - Carle Cancer Center
Urbana, Illinois, 61801, United States
St. Francis Hospital and Health Centers - Beech Grove Campus
Beech Grove, Indiana, 46107, United States
Elkhart General Hospital
Elkhart, Indiana, 46515, United States
Howard Community Hospital at Howard Regional Health System
Kokomo, Indiana, 46904, United States
Center for Cancer Therapy at LaPorte Hospital and Health Services
La Porte, Indiana, 46350, United States
Saint Anthony Memorial Health Centers
Michigan City, Indiana, 46360, United States
Reid Hospital & Health Care Services, Incorporated
Richmond, Indiana, 47374, United States
CCOP - Northern Indiana CR Consortium
South Bend, Indiana, 46601, United States
Memorial Hospital of South Bend
South Bend, Indiana, 46601, United States
Saint Joseph Regional Medical Center
South Bend, Indiana, 46617, United States
Hematology Oncology Associates of the Quad Cities
Bettendorf, Iowa, 52722, United States
Unknown Facility
Bettendorf, Iowa, 52722, United States
St. Luke's Hospital
Cedar Rapids, Iowa, 52402, United States
Cedar Rapids Oncology Associates
Cedar Rapids, Iowa, 52403, United States
Mercy Regional Cancer Center at Mercy Medical Center
Cedar Rapids, Iowa, 52403, United States
Heartland Oncology & Hematology
Council Bluffs, Iowa, 51503, United States
Genesis Regional Cancer Center at Genesis Medical Center
Davenport, Iowa, 52803, United States
Genesis Medical Center - West Campus
Davenport, Iowa, 52804, United States
Mercy Capitol Hospital
Des Moines, Iowa, 50307, United States
CCOP - Iowa Oncology Research Association
Des Moines, Iowa, 50309, United States
John Stoddard Cancer Center at Iowa Methodist Medical Center
Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates at John Stoddard Cancer Center
Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates at Mercy Cancer Center
Des Moines, Iowa, 50314, United States
Mercy Cancer Center at Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314, United States
John Stoddard Cancer Center at Iowa Lutheran Hospital
Des Moines, Iowa, 50316-2301, United States
Mercy Cancer Center at Mercy Medical Center - North Iowa
Mason City, Iowa, 50401, United States
McCreery Cancer Center at Ottumwa Regional
Ottumwa, Iowa, 52501, United States
Siouxland Hematology-Oncology Associates, LLP
Sioux City, Iowa, 51101, United States
Siouxland Regional Cancer Center
Sioux City, Iowa, 51101, United States
Mercy Medical Center - Sioux City
Sioux City, Iowa, 51104, United States
St. Luke's Regional Medical Center
Sioux City, Iowa, 51104, United States
Cedar Valley Medical Specialists, PC - West Ridgeway Avenue
Waterloo, Iowa, 50702, United States
Covenant Cancer Treatment Center
Waterloo, Iowa, 50702, United States
Cancer Center of Kansas, PA - Chanute
Chanute, Kansas, 66720, United States
Cancer Center of Kansas, PA - Dodge City
Dodge City, Kansas, 67801, United States
Cancer Center of Kansas, PA - El Dorado
El Dorado, Kansas, 67042, United States
Veterans Affairs Medical Center - Kansas City
Kansas City, Kansas, 64128, United States
Cancer Center of Kansas, PA - Kingman
Kingman, Kansas, 67068, United States
Southwest Medical Center
Liberal, Kansas, 67901, United States
Cancer Center of Kansas, PA - Newton
Newton, Kansas, 67114, United States
Cancer Center of Kansas, PA - Parsons
Parsons, Kansas, 67357, United States
Cancer Center of Kansas, PA - Pratt
Pratt, Kansas, 67124, United States
Cancer Center of Kansas, PA - Salina
Salina, Kansas, 67042, United States
Tammy Walker Cancer Center at Salina Regional Health Center
Salina, Kansas, 67401, United States
Stormont-Vail Cancer Center
Topeka, Kansas, 66604, United States
Cancer Center of Kansas, PA - Wellington
Wellington, Kansas, 67152, United States
Associates in Womens Health, PA - North Review
Wichita, Kansas, 67203, United States
Cancer Center of Kansas, PA - Medical Arts Tower
Wichita, Kansas, 67208, United States
Cancer Center of Kansas, PA - Wichita
Wichita, Kansas, 67214, United States
CCOP - Wichita
Wichita, Kansas, 67214, United States
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita, Kansas, 67214, United States
Cancer Center of Kansas, PA - Winfield
Winfield, Kansas, 67156, United States
Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County
Madisonville, Kentucky, 42431, United States
Tulane Cancer Center
Alexandria, Louisiana, 71315-3198, United States
Louisiana State University Health Sciences Center - Monroe
Monroe, Louisiana, 71210, United States
Christus Schumpert Cancer Treatment Center
Shreveport, Louisiana, 71101, United States
Veterans Affairs Medical Center - Shreveport
Shreveport, Louisiana, 71101, United States
Feist-Weiller Cancer Center at Louisiana State University Health Sciences
Shreveport, Louisiana, 71130-3932, United States
CancerCare of Maine at Eastern Maine Medial Center
Bangor, Maine, 04401, United States
MaineGeneral Medical Center - Waterville Campus
Waterville, Maine, 04901, United States
Sturdy Memorial Hospital
Attleboro, Massachusetts, 02703, United States
Cancer Research Center at Boston Medical Center
Boston, Massachusetts, 02118, United States
Addison Gilbert Hospital
Gloucester, Massachusetts, 01930, United States
UMASS Memorial Cancer Center - University Campus
Worcester, Massachusetts, 01655, United States
Hickman Cancer Center at Bixby Medical Center
Adrian, Michigan, 49221, United States
Saint Joseph Mercy Cancer Center
Ann Arbor, Michigan, 48106-0995, United States
CCOP - Michigan Cancer Research Consortium
Ann Arbor, Michigan, 48106, United States
Battle Creek Health System Cancer Care Center
Battle Creek, Michigan, 49017, United States
Mecosta County Medical Center
Big Rapids, Michigan, 49307, United States
Josephine Ford Cancer Center at Henry Ford Hospital
Detroit, Michigan, 48202, United States
Green Bay Oncology, Limited - Escanaba
Escanaba, Michigan, 49431, United States
Genesys Hurley Cancer Institute
Flint, Michigan, 48503, United States
Hurley Medical Center
Flint, Michigan, 48503, United States
CCOP - Grand Rapids
Grand Rapids, Michigan, 49503, United States
Lacks Cancer Center at Saint Mary's Health Care
Grand Rapids, Michigan, 49503, United States
Spectrum Health Hospital - Butterworth Campus
Grand Rapids, Michigan, 49503, United States
Metro Health Hospital
Grand Rapids, Michigan, 49506, United States
Van Elslander Cancer Center at St. John Hospital and Medical Center
Grosse Pointe Woods, Michigan, 48236, United States
Holland Community Hospital
Holland, Michigan, 49423, United States
Green Bay Oncology, Limited - Iron Mountain
Iron Mountain, Michigan, 49801, United States
Foote Hospital
Jackson, Michigan, 49201, United States
Borgess Medical Center
Kalamazoo, Michigan, 49001, United States
West Michigan Cancer Center
Kalamazoo, Michigan, 49007-3731, United States
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007, United States
Sparrow Regional Cancer Center
Lansing, Michigan, 48909, United States
Upper Michigan Cancer Center at Marquette General Hospital
Marquette, Michigan, 49855, United States
MidMichigan Medical Center - Midland
Midland, Michigan, 48670, United States
Community Cancer Center of Monroe
Monroe, Michigan, 48162, United States
Mercy Memorial Hospital System
Monroe, Michigan, 48162, United States
Ted B. Wahby Cancer Center at Mount Clemens General Hospital
Mount Clemens, Michigan, 48043, United States
Hackley Hospital
Muskegon, Michigan, 49442, United States
Northern Michigan Hospital
Petoskey, Michigan, 49770, United States
Mercy Regional Cancer Center at Mercy Hospital
Port Huron, Michigan, 48060, United States
Seton Cancer Institute - Saginaw
Saginaw, Michigan, 48601, United States
Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph
Saint Joseph, Michigan, 49085, United States
Munson Medical Center
Traverse City, Michigan, 49684, United States
St. John Macomb Hospital
Warren, Michigan, 48093, United States
Unknown Facility
Alexandria, Minnesota, 56308, United States
MeritCare Clinic - Bemidji
Bemidji, Minnesota, 56601, United States
Fairview Ridges Hospital
Burnsville, Minnesota, 55337, United States
Mercy and Unity Cancer Center at Mercy Hospital
Coon Rapids, Minnesota, 55433, United States
Cancer Care Center at St. Luke's Hospital
Duluth, Minnesota, 55805, United States
CCOP - Duluth
Duluth, Minnesota, 55805, United States
Miller-Dwan Medical Center
Duluth, Minnesota, 55805, United States
St. Mary's - Duluth Clinic Cancer Center
Duluth, Minnesota, 55805, United States
Fairview Southdale Hospital
Edina, Minnesota, 55435, United States
Unknown Facility
Fergus Falls, Minnesota, 56537, United States
Mercy and Unity Cancer Center at Unity Hospital
Fridley, Minnesota, 55432, United States
Hutchinson Area Health Care
Hutchinson, Minnesota, 55350, United States
Meeker County Memorial Hospital
Litchfield, Minnesota, 55355, United States
Immanuel St. Joseph's Clinic
Mankato, Minnesota, 56002, United States
HealthEast Cancer Care at St. John's Hospital
Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology, PA at Maplewood Cancer Center
Maplewood, Minnesota, 55109, United States
Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407, United States
Hennepin County Medical Center - Minneapolis
Minneapolis, Minnesota, 55415, United States
Chippewa County - Montevideo Hospital
Montevideo, Minnesota, 56265, United States
Hubert H. Humphrey Cancer Center at North Memorial Medical Center
Robbinsdale, Minnesota, 55422-2900, United States
Mayo Clinic Cancer Center
Rochester, Minnesota, 55905, United States
CentraCare Clinic - River Campus
Saint Cloud, Minnesota, 56303, United States
Coborn Cancer Center
Saint Cloud, Minnesota, 56303, United States
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, 55416, United States
Park Nicollet Health Services
Saint Louis Park, Minnesota, 55416, United States
Regions Hospital Cancer Care Center
Saint Paul, Minnesota, 55101, United States
St. Joseph's Hospital
Saint Paul, Minnesota, 55102, United States
United Hospital
Saint Paul, Minnesota, 55102, United States
Saint Francis Cancer Center
Shakopee, Minnesota, 55379, United States
Ridgeview Medical Center
Waconia, Minnesota, 55387, United States
Willmar Cancer Center at Rice Memorial Hospital
Willmar, Minnesota, 56201, United States
Minnesota Oncology Hematology, PA - Woodbury
Woodbury, Minnesota, 55125, United States
Woodwinds Health Campus
Woodbury, Minnesota, 55125, United States
University of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
Saint Francis Medical Center
Cape Girardeau, Missouri, 63701, United States
Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
Cape Girardeau, Missouri, 63701, United States
Veterans Affairs Medical Center - Columbia (Truman Memorial)
Columbia, Missouri, 65201, United States
Ellis Fischel Cancer Center at University of Missouri - Columbia
Columbia, Missouri, 65203, United States
Capital Region Cancer Center
Jefferson City, Missouri, 65101, United States
Freeman Cancer Institute at Freeman Health System
Joplin, Missouri, 64804, United States
CCOP - Kansas City
Kansas City, Missouri, 64131, United States
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, 65802, United States
St. John's Regional Health Center
Springfield, Missouri, 65804, United States
Hulston Cancer Center at Cox Medical Center South
Springfield, Missouri, 65807, United States
Missouri Baptist Cancer Center
St Louis, Missouri, 63131, United States
Arch Medical Services, Incorporated at Center for Cancer Care Research
St Louis, Missouri, 63141, United States
CCOP - St. Louis-Cape Girardeau
St Louis, Missouri, 63141, United States
David C. Pratt Cancer Center at St. John's Mercy
St Louis, Missouri, 63141, United States
CCOP - Montana Cancer Consortium
Billings, Montana, 59101, United States
Hematology-Oncology Centers of the Northern Rockies - Billings
Billings, Montana, 59101, United States
Northern Rockies Radiation Oncology Center
Billings, Montana, 59101, United States
St. Vincent Healthcare
Billings, Montana, 59101, United States
Billings Clinic Cancer Center
Billings, Montana, 59107-5100, United States
Deaconess Billings Clinic - Downtown
Billings, Montana, 59107-7000, United States
Bozeman Deaconess Cancer Center
Bozeman, Montana, 59715, United States
St. James Community Hospital
Butte, Montana, 59701, United States
Big Sky Oncology
Great Falls, Montana, 59405, United States
Great Falls Clinic
Great Falls, Montana, 59405, United States
Sletten Regional Cancer Institute at Benefis Healthcare
Great Falls, Montana, 59405, United States
Unknown Facility
Great Falls, Montana, 59405, United States
St. Peter's Hospital
Helena, Montana, 59601, United States
Glacier Oncology, PLLC
Kalispell, Montana, 59901, United States
Kalispell Medical Oncology
Kalispell, Montana, 59901, United States
Kalispell Regional Medical Center
Kalispell, Montana, 59901, United States
Community Medical Center
Missoula, Montana, 59801, United States
Guardian Oncology and Center for Wellness
Missoula, Montana, 59804, United States
Montana Cancer Specialists at Montana Cancer Center
Missoula, Montana, 59807-7877, United States
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
Missoula, Montana, 59807, United States
Good Samaritan Cancer Center at Good Samaritan Hospital
Kearney, Nebraska, 68848-1990, United States
Cancer Resource Center - Lincoln
Lincoln, Nebraska, 68510, United States
CCOP - Missouri Valley Cancer Consortium
Omaha, Nebraska, 68106, United States
Methodist Cancer Center at Methodist Hospital - Omaha
Omaha, Nebraska, 68114, United States
Immanuel Medical Center
Omaha, Nebraska, 68122, United States
Alegant Health Cancer Center at Bergan Mercy Medical Center
Omaha, Nebraska, 68124, United States
Creighton University Medical Center
Omaha, Nebraska, 68131-2197, United States
University Medical Center of Southern Nevada
Las Vegas, Nevada, 89102, United States
CCOP - Nevada Cancer Research Foundation
Las Vegas, Nevada, 89106, United States
Hunterdon Regional Cancer Center at Hunterdon Medical Center
Flemington, New Jersey, 08822, United States
Carol G. Simon Cancer Center at Morristown Memorial Hospital
Morristown, New Jersey, 07962, United States
Jersey Shore Cancer Center at Jersey Shore University Medical Center
Neptune City, New Jersey, 07754-0397, United States
Overlook Hospital
Summit, New Jersey, 07902, United States
Veterans Affairs Medical Center - Buffalo
Buffalo, New York, 14215, United States
Finger Lakes Hematology and Oncology
Clifton Springs, New York, 14432, United States
Adirondack Cancer Care - Glens Falls
Glens Falls, New York, 12801, United States
CCOP - North Shore University Hospital
Manhasset, New York, 11030, United States
Don Monti Comprehensive Cancer Center at North Shore University Hospital
Manhasset, New York, 11030, United States
Tucker Center for Cancer Care at Orange Regional Medical Center
Middletown, New York, 10940-4199, United States
Winthrop University Hospital
Mineola, New York, 11501, United States
Long Island Jewish Medical Center
New Hyde Park, New York, 11042, United States
Interlakes Oncology/Hematology PC
Rochester, New York, 14623, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, 14642, United States
SUNY Upstate Medical University Hospital
Syracuse, New York, 13210, United States
Albert Einstein Cancer Center at Albert Einstein College of Medicine
The Bronx, New York, 10461, United States
Wayne Memorial Hospital, Incorporated
Goldsboro, North Carolina, 27534, United States
Lenoir Memorial Cancer Center
Kinston, North Carolina, 28501, United States
Rutherford Hospital
Rutherfordton, North Carolina, 28139, United States
Zimmer Cancer Center at New Hanover Regional Medical Center
Wilmington, North Carolina, 28401, United States
Bismarck Cancer Center
Bismarck, North Dakota, 58501, United States
Medcenter One Hospital Cancer Care Center
Bismarck, North Dakota, 58501, United States
Mid Dakota Clinic, PC
Bismarck, North Dakota, 58501, United States
St. Alexius Medical Center Cancer Center
Bismarck, North Dakota, 58502, United States
Dakota Cancer Institute at Dakota Clinic - South University
Fargo, North Dakota, 58103, United States
CCOP - MeritCare Hospital
Fargo, North Dakota, 58122, United States
MeritCare Broadway
Fargo, North Dakota, 58122, United States
McDowell Cancer Center at Akron General Medical Center
Akron, Ohio, 44307, United States
Wood County Oncology Center
Bowling Green, Ohio, 43402, United States
Mercy Cancer Center at Mercy Medical Center
Canton, Ohio, 44708, United States
Adena Regional Medical Center
Chillicothe, Ohio, 45601, United States
Charles M. Barrett Cancer Center at University Hospital
Cincinnati, Ohio, 45267, United States
MetroHealth's Cancer Care Center at MetroHealth Medical Center
Cleveland, Ohio, 44109, United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195, United States
Riverside Methodist Hospital Cancer Care
Columbus, Ohio, 43214-3998, United States
CCOP - Columbus
Columbus, Ohio, 43215, United States
Grant Riverside Cancer Services
Columbus, Ohio, 43215, United States
Mount Carmel Health - West Hospital
Columbus, Ohio, 43222, United States
Doctors Hospital at Ohio Health
Columbus, Ohio, 43228, United States
Grandview Hospital
Dayton, Ohio, 45405, United States
Good Samaritan Hospital
Dayton, Ohio, 45406, United States
Samaritan North Cancer Care Center
Dayton, Ohio, 45415, United States
Veterans Affairs Medical Center - Dayton
Dayton, Ohio, 45428, United States
CCOP - Dayton
Dayton, Ohio, 45429, United States
Grady Memorial Hospital
Delaware, Ohio, 43015, United States
Blanchard Valley Medical Associates
Findlay, Ohio, 45840, United States
Fremont Memorial Hospital
Fremont, Ohio, 43420, United States
Community Oncology Group at Cleveland Clinic Cancer Center
Independence, Ohio, 44131, United States
Kenton Oncology, Incorporated
Kenton, Ohio, 43326, United States
Charles F. Kettering Memorial Hospital
Kettering, Ohio, 45429, United States
Fairfield Medical Center
Lancaster, Ohio, 43130, United States
St. Rita's Medical Center
Lima, Ohio, 45801, United States
Lima Memorial Hospital
Lima, Ohio, 45804, United States
MedCentral - Mansfield Hospital
Mansfield, Ohio, 44903, United States
Strecker Cancer Center at Marietta Memorial Hospital
Marietta, Ohio, 45750, United States
St. Luke's Hospital
Maumee, Ohio, 43537, United States
Northwest Ohio Oncology Center
Maumee, Ohio, 43623, United States
Middletown Regional Hospital
Middletown, Ohio, 45044, United States
Licking Memorial Cancer Care Program at Licking Memorial Hospital
Newark, Ohio, 43055, United States
St. Charles Mercy Hospital
Oregon, Ohio, 43616, United States
Toledo Clinic - Oregon
Oregon, Ohio, 43616, United States
Firelands Regional Medical Center
Sandusky, Ohio, 44870, United States
North Coast Cancer Care, Incorporated
Sandusky, Ohio, 44870, United States
Mercy Medical Center
Springfield, Ohio, 45504, United States
Community Hospital of Springfield and Clark County
Springfield, Ohio, 45505, United States
Flower Hospital Cancer Center
Sylvania, Ohio, 43560, United States
Toledo Hospital
Toledo, Ohio, 43606, United States
St. Vincent Mercy Medical Center
Toledo, Ohio, 43608, United States
Medical University of Ohio Cancer Center
Toledo, Ohio, 43614, United States
CCOP - Toledo Community Hospital
Toledo, Ohio, 43617, United States
Toledo Clinic, Incorporated - Main Clinic
Toledo, Ohio, 43623, United States
UVMC Cancer Care Center at Upper Valley Medical Center
Troy, Ohio, 45373-1300, United States
Fulton County Health Center
Wauseon, Ohio, 43567, United States
Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital
Westerville, Ohio, 43081, United States
Cleveland Clinic - Wooster
Wooster, Ohio, 44691, United States
Ruth G. McMillan Cancer Center at Greene Memorial Hospital
Xenia, Ohio, 45385, United States
Tod Children's Hospital - Forum Health
Youngstown, Ohio, 44501, United States
Genesis - Good Samaritan Hospital
Zanesville, Ohio, 43701, United States
Merle West Medical Center Cancer Treatment Center
Klamath Falls, Oregon, 97601, United States
Veterans Affairs Medical Center - Portland
Portland, Oregon, 97207, United States
Kaiser Permanente Health Care - Portland
Portland, Oregon, 97232, United States
Oregon Health & Science University Cancer Institute
Portland, Oregon, 97239-3098, United States
Salem Hospital Regional Cancer Care Services
Salem, Oregon, 97309-5014, United States
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
Allentown, Pennsylvania, 18105, United States
Geisinger Medical Center
Danville, Pennsylvania, 17822-0001, United States
Oncology Hematology Associates of Northern Pennsylvania, PC at Hahne Regional Cancer Center
DuBois, Pennsylvania, 15801, United States
Easton Regional Cancer Center at Easton Hospital
Easton, Pennsylvania, 18042, United States
PinnacleHealth Regional Cancer Center at Polyclinic Hospital
Harrisburg, Pennsylvania, 17105, United States
Lancaster General Hospital
Lancaster, Pennsylvania, 17604, United States
St. Mary Regional Cancer Center
Langhorne, Pennsylvania, 19047, United States
Allegheny Cancer Center at Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212, United States
Mercy Hospital Cancer Center - Scranton
Scranton, Pennsylvania, 18501, United States
Hematology and Oncology Associates of Northeastern Pennsylvania
Scranton, Pennsylvania, 18510, United States
Geisinger Medical Group - Scenery Park
State College, Pennsylvania, 16801, United States
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
Wilkes-Barre, Pennsylvania, 18711, United States
AnMed Cancer Center
Anderson, South Carolina, 29621, United States
Hollings Cancer Center at Medical University of South Carolina
Charleston, South Carolina, 29425, United States
Bon Secours St. Francis Health System
Greenville, South Carolina, 29601, United States
CCOP - Greenville
Greenville, South Carolina, 29615, United States
CCOP - Upstate Carolina
Spartanburg, South Carolina, 29303, United States
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
Spartanburg, South Carolina, 29303, United States
Rapid City Regional Hospital
Rapid City, South Dakota, 57701, United States
Avera Cancer Institute
Sioux Falls, South Dakota, 57105, United States
Medical X-Ray Center, PC
Sioux Falls, South Dakota, 57105, United States
Sioux Valley Hospital and University of South Dakota Medical Center
Sioux Falls, South Dakota, 57117-5039, United States
Thompson Cancer Survival Center
Knoxville, Tennessee, 37916, United States
U.T. Cancer Institute at University of Tennessee Medical Center
Knoxville, Tennessee, 37920-6999, United States
University of Tennessee Cancer Institute - Medical Center
Memphis, Tennessee, 38104, United States
Medical City Dallas Hospital
Dallas, Texas, 75230, United States
Brooke Army Medical Center
Fort Sam Houston, Texas, 78234, United States
Baylor University Medical Center - Houston
Houston, Texas, 77030, United States
Ben Taub General Hospital
Houston, Texas, 77030, United States
Methodist Hospital
Houston, Texas, 77030, United States
St. Luke's Texas Cancer Institute at St. Luke's Episcopal Hospital
Houston, Texas, 77030, United States
Veterans Affairs Medical Center - Houston
Houston, Texas, 77030, United States
Wilford Hall Medical Center
Lackland Air Force Base, Texas, 78236, United States
UMC Southwest Cancer and Research Center
Lubbock, Texas, 79415-3364, United States
Veterans Affairs Medical Center - San Antonio (Murphy)
San Antonio, Texas, 78209, United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229-3900, United States
Cancer Therapy and Research Center
San Antonio, Texas, 78229, United States
University Hospital - San Antonio
San Antonio, Texas, 78229, United States
CCOP - Scott and White Hospital
Temple, Texas, 76508, United States
American Fork Hospital
American Fork, Utah, 84003, United States
Logan Regional Hospital
Logan, Utah, 84321, United States
Cottonwood Hospital Medical Center
Murray, Utah, 84107, United States
McKay-Dee Hospital Center
Ogden, Utah, 84403, United States
Utah Valley Regional Medical Center - Provo
Provo, Utah, 84604, United States
Utah Cancer Specialists at UCS Cancer Center
Salt Lake City, Utah, 84106, United States
Huntsman Cancer Institute at University of Utah
Salt Lake City, Utah, 84112, United States
Latter Day Saints Hospital
Salt Lake City, Utah, 84143, United States
Dixie Regional Medical Center - East Campus
St. George, Utah, 84770, United States
Martha Jefferson Hospital Cancer Care Center
Charlottesville, Virginia, 22901, United States
Danville Regional Medical Center
Danville, Virginia, 24541, United States
Lynchburg Hematology-Oncology Clinic
Lynchburg, Virginia, 24501, United States
Peninsula Cancer Institute - Newport News Office
Newport News, Virginia, 23601, United States
Veterans Affairs Medical Center - Richmond
Richmond, Virginia, 23249, United States
Auburn Regional Center for Cancer Care
Auburn, Washington, 98002, United States
St. Joseph Cancer Center
Bellingham, Washington, 98225, United States
Olympic Hematology and Oncology
Bremerton, Washington, 98310, United States
Providence Centralia Hospital Regional Cancer Center
Centralia, Washington, 98531-9027, United States
St. Francis Hospital
Federal Way, Washington, 98003, United States
Skagit Valley Hospital Cancer Care Center
Mount Vernon, Washington, 98273, United States
Providence St. Peter Hospital Regional Cancer Center
Olympia, Washington, 98506-5166, United States
Good Samaritan Cancer Center
Puyallup, Washington, 98372, United States
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98104, United States
Harborview Medical Center
Seattle, Washington, 98104, United States
Minor and James Medical, PLLC
Seattle, Washington, 98104, United States
Group Health Central Hospital
Seattle, Washington, 98112, United States
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
Seattle, Washington, 98122-4307, United States
Polyclinic First Hill
Seattle, Washington, 98122, United States
University Cancer Center at University of Washington Medical Center
Seattle, Washington, 98195-6043, United States
Cancer Care Northwest - Spokane South
Spokane, Washington, 99202, United States
Rockwood Clinic Cancer Treatment Center
Spokane, Washington, 99204-2967, United States
Providence Cancer Center at Sacred Heart Medical Center
Spokane, Washington, 99204, United States
Providence Cancer Center at Holy Family Hospital
Spokane, Washington, 99207, United States
St. Joseph Medical Center at Franciscan Health System
Tacoma, Washington, 98405-3004, United States
Allenmore Hospital
Tacoma, Washington, 98405, United States
CCOP - Northwest
Tacoma, Washington, 98405, United States
MultiCare Regional Cancer Center at Tacoma General Hospital
Tacoma, Washington, 98405, United States
St. Clare Hospital
Tacoma, Washington, 98499, United States
Wenatchee Valley Medical Center
Wenatchee, Washington, 98801-2028, United States
Fox Valley Hematology and Oncology - East Grant Street
Appleton, Wisconsin, 54911-3496, United States
Green Bay Oncology, Limited at St. Vincent Hospital
Green Bay, Wisconsin, 54301-3526, United States
Green Bay Oncology, Limited at St. Mary's Hospital
Green Bay, Wisconsin, 54303, United States
St. Mary's Hospital Medical Center - Green Bay
Green Bay, Wisconsin, 54303, United States
St. Vincent Hospital Regional Cancer Center
Green Bay, Wisconsin, 54307-3508, United States
Mercy Regional Cancer Center
Janesville, Wisconsin, 53547, United States
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601, United States
Holy Family Memorial Medical Center Cancer Care Center
Manitowoc, Wisconsin, 54221-1450, United States
Bay Area Cancer Care Center at Bay Area Medical Center
Marinette, Wisconsin, 54143, United States
Marshfield Clinic - Marshfield Center
Marshfield, Wisconsin, 54449, United States
Green Bay Oncology, Limited - Oconto Falls
Oconto Falls, Wisconsin, 54154, United States
All Saints Cancer Center at Wheaton Franciscan Healthcare
Racine, Wisconsin, 53405, United States
Marshfield Clinic - Indianhead Center
Rice Lake, Wisconsin, 54868, United States
Green Bay Oncology, Limited - Sturgeon Bay
Sturgeon Bay, Wisconsin, 54235, United States
University of Wisconcin Cancer Center at Aspirus Wausau Hospital
Wausau, Wisconsin, 54401, United States
Welch Cancer Center at Sheridan Memorial Hospital
Sheridan, Wyoming, 82801, United States
Allan Blair Cancer Centre at Pasqua Hospital
Regina, Saskatchewan, S4T 7T1, Canada
Saskatoon Cancer Centre at the University of Saskatchewan
Saskatoon, Saskatchewan, S7N 4H4, Canada
Related Publications (5)
Lara P, Chansky K, Shibata T, et al.: Cisplatin + irinotecan versus cisplatin + etoposide in extensive stage small cell lung cancer (E-SCLC): Final "common arm": comparative outcomes analysis of JCOG 9511 and SWOG 0124. [Abstract] J Clin Oncol 27 (Suppl 15): A-8027, 2009.
BACKGROUNDLara PN Jr, Natale R, Crowley J, Lenz HJ, Redman MW, Carleton JE, Jett J, Langer CJ, Kuebler JP, Dakhil SR, Chansky K, Gandara DR. Phase III trial of irinotecan/cisplatin compared with etoposide/cisplatin in extensive-stage small-cell lung cancer: clinical and pharmacogenomic results from SWOG S0124. J Clin Oncol. 2009 May 20;27(15):2530-5. doi: 10.1200/JCO.2008.20.1061. Epub 2009 Apr 6.
PMID: 19349543RESULTNatale RB, Lara PN, Chansky K, et al.: S0124: A randomized phase III trial comparing irinotecan/cisplatin (IP) with etoposide/cisplatin (EP) in patients (pts) with previously untreated extensive stage small cell lung cancer (E-SCLC). [Abstract] J Clin Oncol 26 (Suppl 15): A-7512, 2008.
RESULTHanna N, Bunn PA Jr, Langer C, Einhorn L, Guthrie T Jr, Beck T, Ansari R, Ellis P, Byrne M, Morrison M, Hariharan S, Wang B, Sandler A. Randomized phase III trial comparing irinotecan/cisplatin with etoposide/cisplatin in patients with previously untreated extensive-stage disease small-cell lung cancer. J Clin Oncol. 2006 May 1;24(13):2038-43. doi: 10.1200/JCO.2005.04.8595.
PMID: 16648503RESULTHanna NH, Einhorn L, Sandler A, et al.: Randomized, phase III trial comparing irinotecan/cisplatin (IP) with etoposide/cisplatin (EP) in patients (pts) with previously untreated, extensive-stage (ES) small cell lung cancer (SCLC). [Abstract] Proceedings of the American Society of Clinical Oncology 23 (Suppl 16): A-LBA7004, 622s, 2005.
RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Lung Committee Statistician
- Organization
- SWOG Statistical Center
Study Officials
- PRINCIPAL INVESTIGATOR
Ronald B. Natale, MD
Cedars-Sinai Medical Center
- PRINCIPAL INVESTIGATOR
David R. Gandara, MD
University of California, Davis
- PRINCIPAL INVESTIGATOR
Primo N. Lara, MD
University of California, Davis
- PRINCIPAL INVESTIGATOR
James R. Jett, MD
Mayo Clinic
- PRINCIPAL INVESTIGATOR
Jane Carleton, MD
Don Monti Comprehensive Cancer Center at North Shore University Hospital
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 6, 2002
First Posted
January 27, 2003
Study Start
November 1, 2002
Primary Completion
March 1, 2008
Study Completion
December 1, 2009
Last Updated
July 31, 2018
Results First Posted
July 9, 2013
Record last verified: 2018-07