AgeUp to 65 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
DISEASE CHARACTERISTICS:
* Diagnosis of Hodgkin's disease or non-Hodgkin's lymphoma
* Failed to achieve a complete remission with initial therapy OR
* Relapsed after initial therapy
* HIV-1 seropositive by Western Blot
* Measurable or evaluable (e.g., pleural fluid involvement) disease
* No leptomeningeal or parenchymal CNS involvement or active CNS leukemia
* HLA-A, B, or DR antigen matched or 1 antigen mismatched related donor available
* CD4 cell count greater than 100/mm3 (initial 12 patients) OR greater than 50/mm3 (subsequent patients)\*
* HIV RNA less than 110,000 copies/mL\* NOTE: \*Unless not receiving optimal anti-retroviral therapy as defined by current clinical standards
PATIENT CHARACTERISTICS:
Age:
* Physiologic 65 and under
Performance status:
* Karnofsky 70-100%
Life expectancy:
* Estimated disease-free survival less than 1 year
Hematopoietic:
* See Disease Characteristics
Hepatic:
* Bilirubin no greater than 2 mg/dL
* Alkaline phosphatase no greater than 3 times upper limit of normal (ULN)\*
* SGOT or SGPT no greater than 3 times ULN\*
* Hepatitis B surface antigen negative NOTE: \*Unless receiving indinavir
Renal:
* Creatinine no greater than 1.5 mg/dL
* Creatinine clearance at least 50 mL/min
Cardiovascular:
* No symptomatic congestive heart failure
* No angina pectoris
* No uncontrolled hypertension
* LVEF at least 45% by radionuclide ventriculography
Pulmonary:
* No severe chronic obstructive lung disease
* No symptomatic restrictive lung disease
* DLCO greater than 50% predicted
Other:
* No active uncontrolled infection
* No history of cytomegalovirus retinitis or pneumonitis, even if treated
* No other disease that would limit life expectancy
* No symptomatic leukoencephalopathy
* No neuropsychiatric abnormalities that would preclude transplantation
* Human T-cell lymphotrophic virus (HTLV-1) antibody negative
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception during and for 3 months after study
PRIOR CONCURRENT THERAPY:
Biologic therapy:
* Not specified
Chemotherapy:
* At least 1 week since prior chemotherapy
Endocrine therapy:
* Not specified
Radiotherapy:
* Not specified
Surgery:
* Not specified
Other:
* No concurrent chronic suppressive therapy