Key Highlights

Risk & Performance

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 65/100

Failure Rate

18.5%

12 terminated/withdrawn out of 65 trials

Success Rate

77.8%

-8.7% vs industry average

Late-Stage Pipeline

11%

7 trials in Phase 3/4

Results Transparency

62%

26 of 42 completed trials have results

Key Signals

6 recruiting26 with results6 terminated6 withdrawn

Enrollment Performance

Analytics

Phase 2

25(52.1%)

Phase 1

9(18.8%)

N/A

6(12.5%)

Phase 3

6(12.5%)

Phase 4

1(2.1%)

Early Phase 1

1(2.1%)

48Total

Phase 2(25)

Phase 1(9)

N/A(6)

Phase 3(6)

+2 more

Activity Timeline

Global Presence

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Clinical Trials (65)

Showing 20 of 65 trials

NCT03603808Phase 2Completed

VGX-3100 and Electroporation in Treating Patients With HIV-Positive High-Grade Anal Lesions

Role: lead

NCT02437851Phase 2Completed

Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection

Role: lead

NCT07539454Phase 2Not Yet Recruiting

Nirogacestat in Patients With Kaposi Sarcoma

Role: lead

NCT05077527Phase 1Recruiting

Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma

Role: lead

NCT03601806Phase 2Completed

Pomalidomide in Treating Patients With Kaposi Sarcoma and Human Immunodeficiency Virus Infection

Role: lead

NCT05510908Completed

Use of a Screening Tool to Describe HIV-Related Cancer Burden and Patient Characteristics in the AMC

Role: lead

NCT04704648Not ApplicableRecruiting

Feasibility Study of Ocular Surface Squamous Neoplasia Surgical Excision in People Living With HIV in Sub-Saharan Africa

Role: lead

NCT04305691Phase 2Recruiting

Trial of Ixazomib for Kaposi Sarcoma

Role: lead

NCT03596918Completed

Evaluating Quality of Life in Patients With AIDS-Associated Kaposi Sarcoma Treated With Bleomycin and Vincristine

Role: lead

NCT05784415Completed

Observational Study of People Living With HIV Treated With CD19-directed CAR T Cell

Role: lead

NCT03284866Phase 3Completed

HPV Vaccine Therapy in Reducing High-Grade Cervical Lesions in Patients With HIV and HPV

Role: lead

NCT05797662Phase 2Not Yet Recruiting

A Study of Propranolol to Treat Kaposi Sarcoma

Role: lead

NCT05411237Phase 3Not Yet Recruiting

Paclitaxel and Pegylated Liposomal Doxorubicin for Treatment of HIV-related Kaposi Sarcoma

Role: lead

NCT04949464Not ApplicableRecruiting

Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study

Role: lead

NCT03077451Phase 2Completed

Nelfinavir Mesylate in Treating Patients With Kaposi Sarcoma

Role: lead

NCT02059499Phase 3Completed

Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions

Role: lead

NCT05663502Recruiting

Collecting Blood and Tissue Sample Donations for Research for HIV/AIDS-Related Cancers

Role: lead

NCT04139304Early Phase 1Recruiting

A Study of Daratumumab and Dose-Adjusted EPOCH in Plasmablastic Lymphoma

Role: lead

NCT04142385Withdrawn

Incidence of HIV Infection in Screening Indian Men Who Have Sex With Men

Role: lead

NCT04142398Withdrawn

Incidence of HPV Infection and HPV-Associated Disease in Screening Indian Men Who Have Sex With HIV-Positive Men

Role: lead