NCT00005487

Brief Summary

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the characteristics of subclinical cardiovascular disease and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease (Bild DE et al., Am J Epidemiol 2002; 156(9):871-881). MESA consists of a diverse, community-based sample of an initial 6,814 men and women aged 45-84 years without known cardiovascular disease at baseline. Thirty-eight percent of the recruited participants were White, 28 percent African American, 22 percent Hispanic, and 12 percent of Chinese descent. Participants were recruited from six field centers across the United States: Baltimore City and Baltimore County, Maryland; Chicago, Illinois; Forsyth County, North Carolina; Los Angeles County, California; New York, New York; and St. Paul, Minnesota. Participants are being followed for identification and characterization of cardiovascular disease events, including acute myocardial infarction and other forms of coronary heart disease (CHD), stroke, and heart failure; for cardiovascular disease interventions; and for mortality. The first examination took place over two years, from July 2000 to July 2002, and has been followed by additional examinations. Participants have been contacted every 9 to 12 months throughout the study to assess and adjudicate clinical morbidity and mortality. The study was approved by the Institutional review boards at all participating institutions, and all participants gave written informed consent. In addition, informed consent was obtained for extensive data sharing (dbGaP) and genetic/omic studies, including candidate genes (NHLBI CARe), genome-wide scans (NHLBI SHARe), exome sequencing (NHLBI ESP) and, most recently, the NHLBI TOPMed program.

Trial Health

83
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
6,418

participants targeted

Target at P75+ for all trials

Timeline
57mo left

Started Jan 1999

Longer than P75 for all trials

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress86%
Jan 1999Dec 2030

Study Start

First participant enrolled

January 1, 1999

Completed
1.4 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
30.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2030

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2030

Last Updated

January 21, 2026

Status Verified

June 1, 2025

Enrollment Period

31.9 years

First QC Date

May 25, 2000

Last Update Submit

January 16, 2026

Conditions

AtherosclerosisCardiovascular DiseasesHeart DiseasesCoronary Artery DiseaseCoronary DiseaseStrokeMyocardial InfarctionHeart FailureDiabetes Mellitus, Type 2HypertensionDiabetes Mellitus

Keywords

Coronary ArteriosclerosisCerebrovascular AccidentHeart Failure, CongestiveDiabetes Mellitus, Non-Insulin Dependent

Outcome Measures

Primary Outcomes (1)

  • CVD

    Rate of Cardiovascular Disease

    06/18/2025

Eligibility Criteria

Age45 Years - 84 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Participants were recruited from the MESA Study Field Centers.

CVD free men and women aged 45-84 at baseline from the four race/ethnic groups.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (77)

  • Azimi A, Atlas K, Reeves AP, Zhang C, Wasserthal J, Mirjalili SR, Atlas T, Henschke CI, Yankelevitz DF, Zulueta JJ, de-Torres JP, Seijo LM, Mechanick JI, Branch A, Ma N, Yip R, Fan W, Roy SK, Nasir K, Molloi S, Fayad ZA, McConnell MV, Kakadiaris IA, Abela GS, Vliegenthart R, Maron DJ, Narula J, Williams KA, Shah PK, Budoff MJ, Levy D, Benjamin EJ, Mehran R, Kloner RA, Wong ND, Naghavi M. Artificial Intelligence-derived Measurements of Myosteatosis from Coronary Artery Calcium CT Scans to Predict COPD: The Multi-Ethnic Study of Atherosclerosis. Radiol Cardiothorac Imaging. 2026 Feb;8(1):e250205. doi: 10.1148/ryct.250205.

    PMID: 41609478DERIVED

  • Ghotbi E, Hathaway QA, Bluemke DA, Ibad HA, Shabani M, Akhtarkhavari S, Barr RG, Post WS, Budoff M, Mathur A, Lima JAC, Demehri S. CT-derived Noncardiovascular Calcifications May Improve Coronary Heart Disease Prediction in Chronic Kidney Disease: The Multi-Ethnic Study of Atherosclerosis. Radiol Cardiothorac Imaging. 2025 Dec;7(6):e240546. doi: 10.1148/ryct.240546.

    PMID: 41342680DERIVED

  • de Alencar JN, Felicioni SP. Electrocardiographic LVH criteria: Poor diagnostic accuracy even with optimized cutoffs. Insights from MESA study. J Electrocardiol. 2025 Nov-Dec;93:154138. doi: 10.1016/j.jelectrocard.2025.154138. Epub 2025 Sep 26.

    PMID: 41027334DERIVED

  • Hoballah M, Chehab O, Abdollahi A, Wu CO, Scarpa B, Post WS, Allen NB, Bluemke DA, Ambale-Venkatesh B, Lima JAC. Left-to-Right Chamber Volume Ratios at Cardiac MRI Predict Cardiac Events: A Multi-Ethnic Study of Atherosclerosis Secondary Analysis. Radiology. 2025 Aug;316(2):e243462. doi: 10.1148/radiol.243462.

    PMID: 40828040DERIVED

  • Hathaway QA, Kasaeian A, Pan T, Bluemke DA, Ghotbi E, Klein JG, Ibad HA, Dailing C, Tison GH, Barr RG, Post W, Allison M, Lima JAC, Budoff M, Demehri S. A Deep Learning Model for Three-Dimensional Determination of Whole Thoracic Vertebral Bone Mineral Density from Noncontrast Chest CT: The Multi-Ethnic Study of Atherosclerosis. Radiology. 2025 Mar;314(3):e242133. doi: 10.1148/radiol.242133.

    PMID: 40067103DERIVED

  • Chan JSK, Satti DI, Chan RNC, Chevli P, Mehta A, Martin SS, Sharma G, Tse G, Virani SS, Shapiro MD. Visit-to-visit lipid variability, coronary artery calcification, inflammation, and mortality in the Multi-Ethnic Study of Atherosclerosis. Eur J Prev Cardiol. 2025 Sep 22;32(13):1235-1244. doi: 10.1093/eurjpc/zwaf085.

    PMID: 39977247DERIVED

  • Amiel PJ, Ambale-Venkatesh B, Wu CO, Matheson M, Ostovaneh MR, Lima JAC, Cox CF. Evaluating Incident Atrial Fibrillation and Incident Heart Failure as Time-varying Covariates for Time-to-Event Analysis Among Adults 55 Years and Older in the Multi-Ethnic Study of Atherosclerosis (MESA). J Card Fail. 2025 Dec;31(12):1809-1818. doi: 10.1016/j.cardfail.2025.01.012. Epub 2025 Feb 3.

    PMID: 39909110DERIVED

  • Osmancevic A, Allison M, Miljkovic I, Vella CA, Ouyang P, Trimpou P, Daka B. Exploring the Relationships between Sex Hormones and Abdominal Muscle Area and Radiodensity in Postmenopausal Women: Insights from the Multi-Ethnic Study of Atherosclerosis. Maturitas. 2025 Mar;194:108197. doi: 10.1016/j.maturitas.2025.108197. Epub 2025 Jan 18.

    PMID: 39827737DERIVED

  • Gao JW, Guo Q, Weng Y, Huang ZG, Zhang HF, Wu YB, Wang JF, Zhang SL, Liu PM. Predicting the risk of coronary artery calcium progression in the general population: insights from the MESA and CARDIA studies. Clin Radiol. 2025 Jan;80:106724. doi: 10.1016/j.crad.2024.10.006. Epub 2024 Oct 16.

    PMID: 39546957DERIVED

  • Tang WHW, Lemaitre RN, Jensen PN, Wang M, Wang Z, Li XS, Nemet I, Lee Y, Lai HTM, de Oliveira Otto MC, Fretts AM, Sotoodehnia N, DiDonato JA, Backhed F, Psaty BM, Siscovick DS, Budoff MJ, Mozaffarian D, Hazen SL. Trimethylamine N-Oxide and Related Gut Microbe-Derived Metabolites and Incident Heart Failure Development in Community-Based Populations. Circ Heart Fail. 2024 Aug;17(8):e011569. doi: 10.1161/CIRCHEARTFAILURE.124.011569. Epub 2024 Aug 9.

    PMID: 39119698DERIVED

  • Abdollahi A, Kato Y, Bakhshi H, Varadarajan V, Chehab O, Zeitoun R, Ostovaneh MR, Wu CO, Bertoni AG, Shah SJ, Ambale-Venkatesh B, Bluemke DA, Lima JAC. Differential Stroke Volume between Left and Right Ventricles as a Predictor of Clinical Outcomes: The MESA Study. Radiology. 2024 Jul;312(1):e232973. doi: 10.1148/radiol.232973.

    PMID: 39041933DERIVED

  • Osmancevic A, Allison M, Miljkovic I, Vella CA, Ouyang P, Trimpou P, Daka B. Levels of Sex Hormones and Abdominal Muscle Composition in Men from The Multi-Ethnic Study of Atherosclerosis. Sci Rep. 2024 Jul 12;14(1):16114. doi: 10.1038/s41598-024-66948-4.

    PMID: 38997435DERIVED

  • Beussink-Nelson L, Freed BH, Chirinos JA, Brubaker PH, Kitzman DW, Yeboah J, Rosas SE, Hu M, Lima JAC, Pandit J, Bertoni AG, Shah SJ. Multi-Ethnic Study of Atherosclerosis Early Heart Failure Study: Rationale, Design, and Baseline Characteristics. Circ Heart Fail. 2024 Mar;17(3):e010289. doi: 10.1161/CIRCHEARTFAILURE.122.010289. Epub 2024 Mar 8.

    PMID: 38456289DERIVED

  • Li ZH, Hao QY, Zeng YH, Guo JB, Li SC, Gao JW, Yang PZ. Remnant cholesterol and the risk of aortic valve calcium progression: insights from the MESA study. Cardiovasc Diabetol. 2024 Jan 9;23(1):20. doi: 10.1186/s12933-023-02081-2.

    PMID: 38195550DERIVED

  • Hathaway Q, Ibad HA, Bluemke DA, Pishgar F, Kasaiean A, Klein JG, Cogswell R, Allison M, Budoff MJ, Barr RG, Post W, Bredella MA, Lima JAC, Demehri S. Predictive Value of Deep Learning-derived CT Pectoralis Muscle and Adipose Measurements for Incident Heart Failure: Multi-Ethnic Study of Atherosclerosis. Radiol Cardiothorac Imaging. 2023 Oct 5;5(5):e230146. doi: 10.1148/ryct.230146. eCollection 2023 Oct.

    PMID: 37908549DERIVED

  • Zghaib T, Quinaglia A C Silva T, Ambale-Venkatesh B, Xie E, Ostovaneh MR, Habibi M, Bluemke DA, Soliman EZ, Wu CO, Heckbert SR, Nazarian S, Lima JAC. Association between Left Atrial Late Gadolinium Enhancement and Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis (MESA). Radiol Cardiothorac Imaging. 2023 Jul 13;5(4):e220047. doi: 10.1148/ryct.220047. eCollection 2023 Aug.

    PMID: 37693199DERIVED

  • Wallace RL, Ogunmoroti O, Zhao D, Vaidya D, Heravi A, Guallar E, Ndumele CE, Lima JAC, Ouyang P, Budoff MJ, Allison M, Thomas I, Fashanu OE, Hoogeveen R, Post WS, Michos ED. Associations of urinary isoprostanes with measures of subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA). Atheroscler Plus. 2022 Dec 21;51:13-21. doi: 10.1016/j.athplu.2022.12.002. eCollection 2023 Mar.

    PMID: 36969704DERIVED

  • Pezel T, Michos ED, Varadarajan V, Shabani M, Venkatesh BA, Vaidya D, Kato Y, De Vasconcellos HD, Heckbert SR, Wu CO, Post WS, Bluemke DA, Allison MA, Henry P, Lima JAC. Prognostic value of a left atrioventricular coupling index in pre- and post-menopausal women from the Multi-Ethnic Study of Atherosclerosis. Front Cardiovasc Med. 2022 Nov 21;9:1066849. doi: 10.3389/fcvm.2022.1066849. eCollection 2022.

    PMID: 36479563DERIVED

  • Ezeigwe A, Ogunmoroti O, Minhas AS, Rodriguez CP, Kazzi B, Fashanu OE, Osibogun O, Kovell LC, Harrington CM, Michos ED. Association between parity and markers of inflammation: The multi-ethnic study of atherosclerosis. Front Cardiovasc Med. 2022 Sep 14;9:922367. doi: 10.3389/fcvm.2022.922367. eCollection 2022.

    PMID: 36186982DERIVED

  • Patel RJS, Ding J, Marvel FA, Shan R, Plante TB, Blaha MJ, Post WS, Martin SS. Associations of Demographic, Socioeconomic, and Cognitive Characteristics With Mobile Health Access: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Heart Assoc. 2022 Sep 6;11(17):e024885. doi: 10.1161/JAHA.121.024885. Epub 2022 Sep 3.

    PMID: 36056720DERIVED

  • Hao QY, Gao JW, Yuan ZM, Gao M, Wang JF, Schiele F, Zhang SL, Liu PM. Remnant Cholesterol and the Risk of Coronary Artery Calcium Progression: Insights From the CARDIA and MESA Study. Circ Cardiovasc Imaging. 2022 Jul;15(7):e014116. doi: 10.1161/CIRCIMAGING.122.014116. Epub 2022 Jul 8.

    PMID: 35861979DERIVED

  • Pezel T, Bluemke DA, Wu CO, Lima JAC, Ambale Venkatesh B. Regional Strain Score as Prognostic Marker of Cardiovascular Events From the Multi-Ethnic Study of Atherosclerosis (MESA). Front Cardiovasc Med. 2022 May 13;9:870942. doi: 10.3389/fcvm.2022.870942. eCollection 2022.

    PMID: 35647063DERIVED

  • Rodriguez CP, Ogunmoroti O, Quispe R, Osibogun O, Ndumele CE, Echouffo Tcheugui J, Minhas AS, Bertoni AG, Allison MA, Michos ED. The Association Between Multiparity and Adipokine Levels: The Multi-Ethnic Study of Atherosclerosis. J Womens Health (Larchmt). 2022 May;31(5):741-749. doi: 10.1089/jwh.2021.0091. Epub 2021 Nov 5.

    PMID: 34747649DERIVED

  • Haslam DE, Peloso GM, Guirette M, Imamura F, Bartz TM, Pitsillides AN, Wang CA, Li-Gao R, Westra JM, Pitkanen N, Young KL, Graff M, Wood AC, Braun KVE, Luan J, Kahonen M, Kiefte-de Jong JC, Ghanbari M, Tintle N, Lemaitre RN, Mook-Kanamori DO, North K, Helminen M, Mossavar-Rahmani Y, Snetselaar L, Martin LW, Viikari JS, Oddy WH, Pennell CE, Rosendall FR, Ikram MA, Uitterlinden AG, Psaty BM, Mozaffarian D, Rotter JI, Taylor KD, Lehtimaki T, Raitakari OT, Livingston KA, Voortman T, Forouhi NG, Wareham NJ, de Mutsert R, Rich SS, Manson JE, Mora S, Ridker PM, Merino J, Meigs JB, Dashti HS, Chasman DI, Lichtenstein AH, Smith CE, Dupuis J, Herman MA, McKeown NM. Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations. Circ Genom Precis Med. 2021 Aug;14(4):e003288. doi: 10.1161/CIRCGEN.120.003288. Epub 2021 Jul 16.

    PMID: 34270325DERIVED

  • Pishgar F, Shabani M, Quinaglia A C Silva T, Bluemke DA, Budoff M, Barr RG, Allison MA, Bertoni AG, Post WS, Lima JAC, Demehri S. Adipose tissue biomarkers and type 2 diabetes incidence in normoglycemic participants in the MESArthritis Ancillary Study: A cohort study. PLoS Med. 2021 Jul 9;18(7):e1003700. doi: 10.1371/journal.pmed.1003700. eCollection 2021 Jul.

    PMID: 34242221DERIVED

  • Jang S, Ogunmoroti O, Zhao D, Fashanu OE, Tibuakuu M, Benson EM, Norby F, Otvos JD, Heckbert SR, Szklo M, Michos ED. The association of novel inflammatory marker GlycA and incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis (MESA). PLoS One. 2021 Mar 25;16(3):e0248644. doi: 10.1371/journal.pone.0248644. eCollection 2021.

    PMID: 33765041DERIVED

  • Kim J, Hiura GT, Oelsner EC, Yin X, Barr RG, Smith BM, Prince MR. Hiatal hernia prevalence and natural history on non-contrast CT in the Multi-Ethnic Study of Atherosclerosis (MESA). BMJ Open Gastroenterol. 2021 Mar;8(1):e000565. doi: 10.1136/bmjgast-2020-000565.

    PMID: 33731384DERIVED

  • Gao JW, Zhang SL, Hao QY, Huang FF, Liu ZY, Zhang HF, Yan L, Wang JF, Liu PM. Association of dietary zinc intake with coronary artery calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA). Eur J Nutr. 2021 Aug;60(5):2759-2767. doi: 10.1007/s00394-020-02452-5. Epub 2021 Jan 4.

    PMID: 33394121DERIVED

  • Fashanu OE, Upadhrasta S, Zhao D, Budoff MJ, Pandey A, Lima JAC, Michos ED. Effect of Progression of Valvular Calcification on Left Ventricular Structure and Frequency of Incident Heart Failure (from the Multiethnic Study of Atherosclerosis). Am J Cardiol. 2020 Nov 1;134:99-107. doi: 10.1016/j.amjcard.2020.08.017. Epub 2020 Aug 15.

    PMID: 32917344DERIVED

  • Jang S, Ogunmoroti O, Ndumele CE, Zhao D, Rao VN, Fashanu OE, Tibuakuu M, Otvos JD, Benson EM, Ouyang P, Michos ED. Association of the Novel Inflammatory Marker GlycA and Incident Heart Failure and Its Subtypes of Preserved and Reduced Ejection Fraction: The Multi-Ethnic Study of Atherosclerosis. Circ Heart Fail. 2020 Aug;13(8):e007067. doi: 10.1161/CIRCHEARTFAILURE.120.007067. Epub 2020 Jul 28.

    PMID: 32762458DERIVED

  • Karger AB, Steffen BT, Nomura SO, Guan W, Garg PK, Szklo M, Budoff MJ, Tsai MY. Association Between Homocysteine and Vascular Calcification Incidence, Prevalence, and Progression in the MESA Cohort. J Am Heart Assoc. 2020 Feb 4;9(3):e013934. doi: 10.1161/JAHA.119.013934. Epub 2020 Jan 30.

    PMID: 32013703DERIVED

  • Ostovaneh MR, Moazzami K, Yoneyama K, A Venkatesh B, Heckbert SR, Wu CO, Shea S, Post WS, Fitzpatrick AL, Burke GL, Bahrami H, Sanchez OA, Daniels LB, Michos ED, Bluemke DA, Lima JAC. Change in NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) Level and Risk of Dementia in Multi-Ethnic Study of Atherosclerosis (MESA). Hypertension. 2020 Feb;75(2):316-323. doi: 10.1161/HYPERTENSIONAHA.119.13952. Epub 2019 Dec 23.

    PMID: 31865797DERIVED

  • Kawel-Boehm N, Kronmal R, Eng J, Folsom A, Burke G, Carr JJ, Shea S, Lima JAC, Bluemke DA. Left Ventricular Mass at MRI and Long-term Risk of Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis (MESA). Radiology. 2019 Oct;293(1):107-114. doi: 10.1148/radiol.2019182871. Epub 2019 Aug 27.

    PMID: 31453766DERIVED

  • Block RC, Liu L, Herrington DM, Huang S, Tsai MY, O'Connell TD, Shearer GC. Predicting Risk for Incident Heart Failure With Omega-3 Fatty Acids: From MESA. JACC Heart Fail. 2019 Aug;7(8):651-661. doi: 10.1016/j.jchf.2019.03.008. Epub 2019 Jul 10.

    PMID: 31302044DERIVED

  • Fashanu OE, Oyenuga AO, Zhao D, Tibuakuu M, Mora S, Otvos JD, Stein JH, Michos ED. GlycA, a Novel Inflammatory Marker and Its Association With Peripheral Arterial Disease and Carotid Plaque: The Multi-Ethnic Study of Atherosclerosis. Angiology. 2019 Sep;70(8):737-746. doi: 10.1177/0003319719845185. Epub 2019 Apr 28.

    PMID: 31030528DERIVED

  • Fliotsos M, Zhao D, Rao VN, Ndumele CE, Guallar E, Burke GL, Vaidya D, Delaney JCA, Michos ED. Body Mass Index From Early-, Mid-, and Older-Adulthood and Risk of Heart Failure and Atherosclerotic Cardiovascular Disease: MESA. J Am Heart Assoc. 2018 Nov 20;7(22):e009599. doi: 10.1161/JAHA.118.009599.

    PMID: 30571492DERIVED

  • Rao VN, Zhao D, Allison MA, Guallar E, Sharma K, Criqui MH, Cushman M, Blumenthal RS, Michos ED. Adiposity and Incident Heart Failure and its Subtypes: MESA (Multi-Ethnic Study of Atherosclerosis). JACC Heart Fail. 2018 Dec;6(12):999-1007. doi: 10.1016/j.jchf.2018.07.009. Epub 2018 Oct 10.

    PMID: 30316935DERIVED

  • Ying W, Zhao D, Ouyang P, Subramanya V, Vaidya D, Ndumele CE, Sharma K, Shah SJ, Heckbert SR, Lima JA, deFilippi CR, Budoff MJ, Post WS, Michos ED. Sex Hormones and Change in N-Terminal Pro-B-Type Natriuretic Peptide Levels: The Multi-Ethnic Study of Atherosclerosis. J Clin Endocrinol Metab. 2018 Nov 1;103(11):4304-4314. doi: 10.1210/jc.2018-01437.

    PMID: 30137406DERIVED

  • Yoneyama K, Venkatesh BA, Wu CO, Mewton N, Gjesdal O, Kishi S, McClelland RL, Bluemke DA, Lima JAC. Diabetes mellitus and insulin resistance associate with left ventricular shape and torsion by cardiovascular magnetic resonance imaging in asymptomatic individuals from the multi-ethnic study of atherosclerosis. J Cardiovasc Magn Reson. 2018 Jul 30;20(1):53. doi: 10.1186/s12968-018-0472-9.

    PMID: 30064457DERIVED

  • Kim SM, Zhao D, Podolanczuk AJ, Lutsey PL, Guallar E, Kawut SM, Barr RG, de Boer IH, Kestenbaum BR, Lederer DJ, Michos ED. Serum 25-Hydroxyvitamin D Concentrations Are Associated with Computed Tomography Markers of Subclinical Interstitial Lung Disease among Community-Dwelling Adults in the Multi-Ethnic Study of Atherosclerosis (MESA). J Nutr. 2018 Jul 1;148(7):1126-1134. doi: 10.1093/jn/nxy066.

    PMID: 29931068DERIVED

  • Al Rifai M, Greenland P, Blaha MJ, Michos ED, Nasir K, Miedema MD, Yeboah J, Sandfort V, Frazier-Wood AC, Shea S, Lima JA, Szklo M, Post WS, Blumenthal RS, McEvoy JW. Factors of health in the protection against death and cardiovascular disease among adults with subclinical atherosclerosis. Am Heart J. 2018 Apr;198:180-188. doi: 10.1016/j.ahj.2017.10.026. Epub 2017 Nov 11.

    PMID: 29653643DERIVED

  • Patel J, Al Rifai M, Scheuner MT, Shea S, Blumenthal RS, Nasir K, Blaha MJ, McEvoy JW. Basic vs More Complex Definitions of Family History in the Prediction of Coronary Heart Disease: The Multi-Ethnic Study of Atherosclerosis. Mayo Clin Proc. 2018 Sep;93(9):1213-1223. doi: 10.1016/j.mayocp.2018.01.014. Epub 2018 Mar 16.

    PMID: 29555305DERIVED

  • Liu CY, Heckbert SR, Lai S, Ambale-Venkatesh B, Ostovaneh MR, McClelland RL, Lima JAC, Bluemke DA. Association of Elevated NT-proBNP With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis (MESA). J Am Coll Cardiol. 2017 Dec 26;70(25):3102-3109. doi: 10.1016/j.jacc.2017.10.044.

    PMID: 29268924DERIVED

  • Tibuakuu M, Jones MR, Navas-Acien A, Zhao D, Guallar E, Gassett AJ, Sheppard L, Budoff MJ, Kaufman JD, Michos ED. Exposure to ambient air pollution and calcification of the mitral annulus and aortic valve: the multi-ethnic study of atherosclerosis (MESA). Environ Health. 2017 Dec 21;16(1):133. doi: 10.1186/s12940-017-0346-x.

    PMID: 29268751DERIVED

  • McKeown NM, Dashti HS, Ma J, Haslam DE, Kiefte-de Jong JC, Smith CE, Tanaka T, Graff M, Lemaitre RN, Rybin D, Sonestedt E, Frazier-Wood AC, Mook-Kanamori DO, Li Y, Wang CA, Leermakers ETM, Mikkila V, Young KL, Mukamal KJ, Cupples LA, Schulz CA, Chen TA, Li-Gao R, Huang T, Oddy WH, Raitakari O, Rice K, Meigs JB, Ericson U, Steffen LM, Rosendaal FR, Hofman A, Kahonen M, Psaty BM, Brunkwall L, Uitterlinden AG, Viikari J, Siscovick DS, Seppala I, North KE, Mozaffarian D, Dupuis J, Orho-Melander M, Rich SS, de Mutsert R, Qi L, Pennell CE, Franco OH, Lehtimaki T, Herman MA. Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis. Diabetologia. 2018 Feb;61(2):317-330. doi: 10.1007/s00125-017-4475-0. Epub 2017 Nov 2.

    PMID: 29098321DERIVED

  • Inoue YY, Soliman EZ, Yoneyama K, Ambale-Venkatesh B, Wu CO, Sparapani R, Bluemke DA, Lima JAC, Ashikaga H. Electrocardiographic Strain Pattern Is Associated With Left Ventricular Concentric Remodeling, Scar, and Mortality Over 10 Years: The Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2017 Sep 20;6(9):e006624. doi: 10.1161/JAHA.117.006624.

    PMID: 28931529DERIVED

  • Ambale-Venkatesh B, Yang X, Wu CO, Liu K, Hundley WG, McClelland R, Gomes AS, Folsom AR, Shea S, Guallar E, Bluemke DA, Lima JAC. Cardiovascular Event Prediction by Machine Learning: The Multi-Ethnic Study of Atherosclerosis. Circ Res. 2017 Oct 13;121(9):1092-1101. doi: 10.1161/CIRCRESAHA.117.311312. Epub 2017 Aug 9.

    PMID: 28794054DERIVED

  • Chandler PD, Akinkuolie AO, Tobias DK, Lawler PR, Li C, Moorthy MV, Wang L, Duprez DA, Jacobs DR, Glynn RJ, Otvos J, Connelly MA, Post WS, Ridker PM, Manson JE, Buring JE, Lee IM, Mora S. Association of N-Linked Glycoprotein Acetyls and Colorectal Cancer Incidence and Mortality. PLoS One. 2016 Nov 30;11(11):e0165615. doi: 10.1371/journal.pone.0165615. eCollection 2016.

    PMID: 27902713DERIVED

  • Levitan EB, Ahmed A, Arnett DK, Polak JF, Hundley WG, Bluemke DA, Heckbert SR, Jacobs DR Jr, Nettleton JA. Mediterranean diet score and left ventricular structure and function: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr. 2016 Sep;104(3):595-602. doi: 10.3945/ajcn.115.128579. Epub 2016 Aug 3.

    PMID: 27488238DERIVED

  • Leary PJ, Tedford RJ, Bluemke DA, Bristow MR, Heckbert SR, Kawut SM, Krieger EV, Lima JA, Masri CS, Ralph DD, Shea S, Weiss NS, Kronmal RA. Histamine H2 Receptor Antagonists, Left Ventricular Morphology, and Heart Failure Risk: The MESA Study. J Am Coll Cardiol. 2016 Apr 5;67(13):1544-1552. doi: 10.1016/j.jacc.2016.01.045.

    PMID: 27150686DERIVED

  • Oelsner EC, Loehr LR, Henderson AG, Donohue KM, Enright PL, Kalhan R, Lo Cascio CM, Ries A, Shah N, Smith BM, Rosamond WD, Barr RG. Classifying Chronic Lower Respiratory Disease Events in Epidemiologic Cohort Studies. Ann Am Thorac Soc. 2016 Jul;13(7):1057-66. doi: 10.1513/AnnalsATS.201601-063OC.

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  • Medrano-Gracia P, Cowan BR, Ambale-Venkatesh B, Bluemke DA, Eng J, Finn JP, Fonseca CG, Lima JA, Suinesiaputra A, Young AA. Left ventricular shape variation in asymptomatic populations: the Multi-Ethnic Study of Atherosclerosis. J Cardiovasc Magn Reson. 2014 Jul 30;16(1):56. doi: 10.1186/s12968-014-0056-2.

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  • Sharma RK, Volpe G, Rosen BD, Ambale-Venkatesh B, Donekal S, Fernandes V, Wu CO, Carr J, Bluemke DA, Lima JA. Prognostic implications of left ventricular dyssynchrony for major adverse cardiovascular events in asymptomatic women and men: the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2014 Aug 4;3(4):e000975. doi: 10.1161/JAHA.114.000975.

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  • Imai M, Ambale Venkatesh B, Samiei S, Donekal S, Habibi M, Armstrong AC, Heckbert SR, Wu CO, Bluemke DA, Lima JA. Multi-ethnic study of atherosclerosis: association between left atrial function using tissue tracking from cine MR imaging and myocardial fibrosis. Radiology. 2014 Dec;273(3):703-13. doi: 10.1148/radiol.14131971. Epub 2014 Jul 14.

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  • Opdahl A, Ambale Venkatesh B, Fernandes VRS, Wu CO, Nasir K, Choi EY, Almeida ALC, Rosen B, Carvalho B, Edvardsen T, Bluemke DA, Lima JAC. Resting heart rate as predictor for left ventricular dysfunction and heart failure: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol. 2014 Apr 1;63(12):1182-1189. doi: 10.1016/j.jacc.2013.11.027. Epub 2014 Jan 8.

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  • Ambale-Venkatesh B, Armstrong AC, Liu CY, Donekal S, Yoneyama K, Wu CO, Gomes AS, Hundley GW, Bluemke DA, Lima JA. Diastolic function assessed from tagged MRI predicts heart failure and atrial fibrillation over an 8-year follow-up period: the multi-ethnic study of atherosclerosis. Eur Heart J Cardiovasc Imaging. 2014 Apr;15(4):442-9. doi: 10.1093/ehjci/jet189. Epub 2013 Oct 20.

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  • Tanaka T, Ngwa JS, van Rooij FJ, Zillikens MC, Wojczynski MK, Frazier-Wood AC, Houston DK, Kanoni S, Lemaitre RN, Luan J, Mikkila V, Renstrom F, Sonestedt E, Zhao JH, Chu AY, Qi L, Chasman DI, de Oliveira Otto MC, Dhurandhar EJ, Feitosa MF, Johansson I, Khaw KT, Lohman KK, Manichaikul A, McKeown NM, Mozaffarian D, Singleton A, Stirrups K, Viikari J, Ye Z, Bandinelli S, Barroso I, Deloukas P, Forouhi NG, Hofman A, Liu Y, Lyytikainen LP, North KE, Dimitriou M, Hallmans G, Kahonen M, Langenberg C, Ordovas JM, Uitterlinden AG, Hu FB, Kalafati IP, Raitakari O, Franco OH, Johnson A, Emilsson V, Schrack JA, Semba RD, Siscovick DS, Arnett DK, Borecki IB, Franks PW, Kritchevsky SB, Lehtimaki T, Loos RJ, Orho-Melander M, Rotter JI, Wareham NJ, Witteman JC, Ferrucci L, Dedoussis G, Cupples LA, Nettleton JA. Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. Am J Clin Nutr. 2013 Jun;97(6):1395-402. doi: 10.3945/ajcn.112.052183. Epub 2013 May 1.

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  • Mozaffarian D, de Oliveira Otto MC, Lemaitre RN, Fretts AM, Hotamisligil G, Tsai MY, Siscovick DS, Nettleton JA. trans-Palmitoleic acid, other dairy fat biomarkers, and incident diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr. 2013 Apr;97(4):854-61. doi: 10.3945/ajcn.112.045468. Epub 2013 Feb 13.

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  • Krishnan RM, Adar SD, Szpiro AA, Jorgensen NW, Van Hee VC, Barr RG, O'Neill MS, Herrington DM, Polak JF, Kaufman JD. Vascular responses to long- and short-term exposure to fine particulate matter: MESA Air (Multi-Ethnic Study of Atherosclerosis and Air Pollution). J Am Coll Cardiol. 2012 Nov 20;60(21):2158-66. doi: 10.1016/j.jacc.2012.08.973. Epub 2012 Oct 24.

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  • Dibble CT, Lima JAC, Bluemke DA, Chirinos JA, Chahal H, Bristow MR, Kronmal RA, Barr RG, Ferrari VA, Propert KJ, Kawut SM. Regional left ventricular systolic function and the right ventricle: the multi-ethnic study of atherosclerosis right ventricle study. Chest. 2011 Aug;140(2):310-316. doi: 10.1378/chest.10-1750. Epub 2011 Feb 17.

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  • Moran A, Katz R, Jenny NS, Astor B, Bluemke DA, Lima JA, Siscovick D, Bertoni AG, Shlipak MG. Left ventricular hypertrophy in mild and moderate reduction in kidney function determined using cardiac magnetic resonance imaging and cystatin C: the multi-ethnic study of atherosclerosis (MESA). Am J Kidney Dis. 2008 Nov;52(5):839-48. doi: 10.1053/j.ajkd.2008.06.012. Epub 2008 Oct 8.

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Related Links

MeSH Terms

Conditions

AtherosclerosisCardiovascular DiseasesHeart DiseasesCoronary Artery DiseaseCoronary DiseaseStrokeMyocardial InfarctionHeart FailureDiabetes Mellitus, Type 2HypertensionDiabetes Mellitus

Condition Hierarchy (Ancestors)

ArteriosclerosisArterial Occlusive DiseasesVascular DiseasesMyocardial IschemiaCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosisGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Officials

  • Robyn McClelland

    University of Washington

    PRINCIPAL INVESTIGATOR

  • Steven Shea

    Columbia University

    PRINCIPAL INVESTIGATOR

  • Wendy Post

    Johns Hopkins University

    PRINCIPAL INVESTIGATOR

  • Norrina Allen

    Northwestern University

    PRINCIPAL INVESTIGATOR

  • Karol Watson

    University of California, Los Angeles

    PRINCIPAL INVESTIGATOR

  • James Pankow

    University of Minnesota

    PRINCIPAL INVESTIGATOR

  • Nels Olson

    University of Vermont (biospecimen repository)

    PRINCIPAL INVESTIGATOR

  • Alain Bertoni

    Wake Forest University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
NIH
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

January 1, 1999

Primary Completion (Estimated)

December 1, 2030

Study Completion (Estimated)

December 1, 2030

Last Updated

January 21, 2026

Record last verified: 2025-06