Matrix-Directed Therapy In Older Adolescents And Adults With Osteogenesis Imperfecta

You may not qualify if:

• Does not have any other contraindication that makes the patient unsuitable to take part in the study in the opinion of the investigator.
• Prior treatment with the oral bisphosphonate risedronate of any duration is permitted provided there has been a 12 month washout period since the last dose of treatment was given
• Current use of losartan
• Known hypersensitivity to losartan or any of the excipients
• Prior use of losartan within preceding 6 month to enrolment
• Recent fracture in the prior 6 months to enrolment
• Presence of other chronic illnesses including renal failure likely to affect bone metabolism or structure. GFR in children will be assessed using the Bedside Schwartz equation
• Known severe hypotension resulting in dizziness, fainting or headaches
• Hyperkalaemia
• Current medication that increases potassium retention, or may increase potassium levels, such as potassium-retaining diuretics
• Current medication with lithium
• Current medication with other substances which may induce hypotension
• Currently taking oral bisphosphonates or intravenous bisphosphonates
• Prior treatment with more than 6 weeks oral bisphosphonates treatment within 10 years of the consent
• Prior treatment with more than a single dose of intravenous bisphosphonate within 10 years of the consent
• +10 more criteria