Key Insights

Highlights

Success Rate

89% trial completion (above average)

Published Results

12 trials with published results (16%)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 40/100

Termination Rate

6.8%

5 terminated out of 73 trials

Success Rate

88.9%

+2.3% vs benchmark

Late-Stage Pipeline

21%

15 trials in Phase 3/4

Results Transparency

30%

12 of 40 completed with results

Key Signals

12 with results89% success

Data Visualizations

Phase Distribution

52Total
Not Applicable (19)
P 1 (9)
P 2 (9)
P 3 (9)
P 4 (6)

Trial Status

Completed40
Active Not Recruiting9
Recruiting8
Unknown6
Terminated5
Not Yet Recruiting4

Trial Success Rate

88.9%

Benchmark: 86.5%

Based on 40 completed trials

Clinical Trials (73)

Showing 20 of 20 trials
NCT00076830Completed

Evaluation and Treatment of Patients With Connective Tissue Disease

NCT00001594CompletedPrimary

Evaluation and Intervention for the Effects of Osteogenesis Imperfecta

NCT07666269Not ApplicableNot Yet RecruitingPrimary

Morphology in Oral Rare Syndromes & Artificial Intelligence for Clinical Diagnosis

NCT07366086Phase 3RecruitingPrimary

Pediatric Safety Follow-up Study of Prior Treatment With Romosozumab for Osteogenesis Imperfecta

NCT06636071Phase 3Active Not RecruitingPrimary

Setrusumab in Pediatric Japanese Subjects With Osteogenesis Imperfecta

NCT03735537Phase 4CompletedPrimary

Treatment of Osteogenesis Imperfecta With Parathyroid Hormone and Zoledronic Acid

NCT05972551Phase 3Active Not RecruitingPrimary

Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta

NCT06193642Not ApplicableCompletedPrimary

Increasing Knowledge on Osteogenesis Imperfecta by Collecting Epidemiological Data

NCT05559801Phase 1Not Yet RecruitingPrimary

Mesenchymal Cell Therapy in Osteogenesis Imperfecta (OI)

NCT05927389Not ApplicableRecruitingPrimary

Adapted Physical Activity Program (APA) for Effort Rehabilitation of Children and Teenagers With Osteogenesis Imperfecta

NCT04152551Phase 4RecruitingPrimary

Effects of Bisphosphonates on OI-Related Hearing Loss

NCT05317637Active Not RecruitingPrimary

Cardiopulmonary Outcomes in Osteogenesis Imperfecta: BBD7708

NCT05768854Phase 3Active Not RecruitingPrimary

Setrusumab vs Bisphosphonates in Pediatric Subjects With Osteogenesis Imperfecta

NCT05125809Phase 2Active Not RecruitingPrimary

Setrusumab vs Placebo for Osteogenesis Imperfecta

NCT03575221CompletedPrimary

Natural History of the Collagen-Related Disorder Osteogenesis Imperfecta and Genotype Phenotype Correlation

NCT07412782Not ApplicableRecruitingPrimary

REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD)

NCT02934451Active Not RecruitingPrimary

Dental Malocclusion and Craniofacial Development in OI

NCT05612139CompletedPrimary

Post-market Observational Study on JTIN Telescopic Nail in Osteogenesis Imperfecta Pediatric Patients

NCT07287241Recruiting

Prospective Observational Cohort Study of Cardiac Structure and Function in Children and Adults With Osteogenesis Imperfecta

NCT04815564Not ApplicableActive Not RecruitingPrimary

Clear Aligners for the Treatment of Dental Malocclusion in OI

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Research Network

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