NCT04295590

Brief Summary

The purpose of this study is to compare the impact of augmenting exercise intensity and augmenting exercise frequency on peak work rate. Participants will complete exercise tests and provide 8 skeletal muscle samples following a within-subjects randomized crossover design utilizing single-leg cycling. Both training periods will be 4 weeks long and skeletal muscle biopsies will be collected from both legs before and after each training period. All exercise sessions will be supervised, take place in the investigator's laboratory, and occur on stationary bikes.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
16

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Sep 2019

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 30, 2019

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

March 2, 2020

Completed
2 days until next milestone

First Posted

Study publicly available on registry

March 4, 2020

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 10, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 10, 2020

Completed
Last Updated

March 4, 2020

Status Verified

March 1, 2020

Enrollment Period

6 months

First QC Date

March 2, 2020

Last Update Submit

March 3, 2020

Conditions

Exercise Training

Outcome Measures

Primary Outcomes (1)

  • Peak work rate

    Change in Highest work rate achieved (30s period) during incremental exercise tests

    Before exercise training on two days (~7 and 6 days before first training session; ~24 hours apart), and after exercise on two days (~48-96 hours after the last training session; ~24 hours apart)

Secondary Outcomes (2)

  • Peak oxygen uptake

    Before exercise training on two days (~7 and 6 days before first training session; ~24 hours apart), and after exercise on two days (~48-96 hours after the last training session; ~24 hours apart)

  • Maximal citrate synthase activity

    Before exercise training (~7 days before first training session), and after exercise training (~48-72 hours after the last training session)

Study Arms (2)

Frequency then Intensity

EXPERIMENTAL

Training period 1: Frequency comparison Training period 2: Intensity comparison

Behavioral: Frequency comparisonBehavioral: Intensity comparison

Intensity then Frequency

EXPERIMENTAL

Training period 1: Intensity comparison Training period 2: Frequency comparison

Behavioral: Frequency comparisonBehavioral: Intensity comparison

Interventions

Frequency comparisonBEHAVIORAL

One leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to high-frequency low-intensity (5 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery).

Frequency then IntensityIntensity then Frequency
Intensity comparisonBEHAVIORAL

One leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to low-frequency high-intensity (3 days per week of 8 x 1 min @ 100% peak work rate interspersed with 1-minute periods of active recovery).

Frequency then IntensityIntensity then Frequency

Eligibility Criteria

Age18 Years - 30 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Recreational active (\<3 hours per week of aerobic exercise)
  • Willing to provide skeletal muscle biopsies

You may not qualify if:

  • Cardiovascular or metabolic disease
  • Athletes or individuals exceeding 3 hours per week of aerobic exercise
  • Smokers

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Queen's Muscle Physiology Lab in the School of Kinesiology and Health Studies at Queen's University

Kingston, Ontario, K7L 3N6, Canada

Location

Study Officials

  • Brendon J Gurd, PhD

    Queen's University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Professor, School of Kinesiology & Health Studies, Queen's University

Study Record Dates

First Submitted

March 2, 2020

First Posted

March 4, 2020

Study Start

September 30, 2019

Primary Completion

April 10, 2020

Study Completion

April 10, 2020

Last Updated

March 4, 2020

Record last verified: 2020-03

Data Sharing

IPD Sharing
Will not share

Locations

CA(1)