NCT05427357

Brief Summary

Non-selective closed kinetic chain exercises and or selective closed kinetic chain exercises has been shown to increase Vastus medialis obliquus muscle power in patellofemoral pain syndrome. However, the superiority of the exercises to each other has not been shown. This study aimed to evaluating the effects of different exercises on the stiffness of the Vastus medialis obliquus and vastus lateralis muscles, pain management, functional scores, and thigh circumferences.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Dec 2016

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2016

Completed
Same day until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2016

Completed
1.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2018

Completed
4.3 years until next milestone

First Submitted

Initial submission to the registry

June 7, 2022

Completed
15 days until next milestone

First Posted

Study publicly available on registry

June 22, 2022

Completed
Last Updated

June 22, 2022

Status Verified

June 1, 2022

Enrollment Period

Same day

First QC Date

June 7, 2022

Last Update Submit

June 16, 2022

Conditions

Keywords

Elastographyexercisesnon-selectivepainpatellofemoral

Outcome Measures

Primary Outcomes (2)

  • Shear Wave Elastography

    Measurement of muscle strength before exercises

    1 day before exercise program

  • Shear Wave Elastography

    Measurement of muscle strength after exercises

    6 weeks after exercise program

Study Arms (3)

Diseased side of the patellofemoral pain syndrome (PFPS) group (40 knees)

EXPERIMENTAL

Non-selective close kinetic chain exercises and selective close kinetic chain exercises were applied for 6 weeks in diseased side of the PFPS group. Thigh circumference measurement was performed 5-10 cm above the upper pole of the patella. In addition, evaluation was made with visual analog score (VAS) and Lysholm Knee score (LKS). Vastus medialis obliquus (VMO) and vastus lateralis (VL) muscles of the participants were measured with Shear Wave Elastography 1 day before the therapy and 6 weeks after therapy in hospital.

Other: Non-selective closed kinetic chain exercises (NSKCE) and selective closed kinetic chain exercises (SCKCE)

Healthy side of the patellofemoral pain syndrome (PFPS) group (40 knees)

EXPERIMENTAL

Non-selective close kinetic chain exercises and selective close kinetic chain exercises were applied for 6 weeks in healthy side of the PFPS group. Thigh circumference measurement was performed 5-10 cm above the upper pole of the patella. In addition, evaluation was made with visual analog score (VAS) and Lysholm Knee score (LKS). Vastus medialis obliquus (VMO) and vastus lateralis (VL) muscles of the participants were measured with Shear Wave Elastography 1 day before the therapy and 6 weeks after therapy in hospital.

Other: Non-selective closed kinetic chain exercises (NSKCE) and selective closed kinetic chain exercises (SCKCE)

Both side of the healthy control group (80 knees)

OTHER

Non-selective close kinetic chain exercises and selective close kinetic chain exercises were applied for 6 weeks in side of the both side of the healthy control group. Thigh circumference measurement was performed 5-10 cm above the upper pole of the patella. In addition, evaluation was made with visual analog score (VAS) and Lysholm Knee score (LKS). Vastus medialis obliquus (VMO) and vastus lateralis (VL) muscles of the participants were measured with Shear Wave Elastography 1 day before the therapy and 6 weeks after therapy in hospital.

Other: Non-selective closed kinetic chain exercises (NSKCE) and selective closed kinetic chain exercises (SCKCE)

Interventions

Non-selective closed kinetic chain double-leg semi-squat exercise In this exercise, the standing patient leans his or her back against the wall and slides down the wall until the knees are about 45 degrees flexed. Daily program was determined as 5 sessions and 10 repeats. The knee stayed at flexion position for 10 seconds in each repeat, which aimed the contraction of quadriceps muscle. There is a relaxation period for 5 seconds between each repeat. Selective closed kinetic chain double-leg semi-squat exercise with hip adduction In this exercise, the standing patient leans his or her back against the wall, forces the knees for adduction by squeezing the pillow placed between the knees and slides down the wall until the knees are about 45 degrees flexed. Daily program was determined as 5 sessions and 10 repeats.

Both side of the healthy control group (80 knees)Diseased side of the patellofemoral pain syndrome (PFPS) group (40 knees)Healthy side of the patellofemoral pain syndrome (PFPS) group (40 knees)

Eligibility Criteria

Age17 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Having peripatellar/retropatellar pain while sitting,going up and down the stairs
  • Walking for a long time, crouching down, running, and kneeling down
  • Having a VAS score of ≥3 during the evaluation and not developing these symptoms on a traumatic basis

You may not qualify if:

  • Tendinitis
  • Osgood-Schlatter Syndrome
  • Traumatic hip or knee injuries
  • Osteoarthritis
  • Plica syndrome
  • Sinding-Larsen-Johansson syndrome
  • Ligamentous instability
  • Spinal pain
  • Chondral lesion
  • Patellar tendon pathology
  • Distraction apophysitis of knee circumference

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Kultur Y, Harbiyeli E, Botanlioglu H, Ozsahin MK, Ozturhalli S, Aydingoz O, Erginer MR. Evaluation of the results of closed kinetic chain exercises applied in the conservative treatment of patellofemoral pain syndrome by means of shear wave elastography: A randomized controlled trial. J Orthop Surg (Hong Kong). 2024 Sep-Dec;32(3):10225536241280384. doi: 10.1177/10225536241280384.

MeSH Terms

Conditions

Motor ActivityPain

Condition Hierarchy (Ancestors)

BehaviorNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
FACTORIAL
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 7, 2022

First Posted

June 22, 2022

Study Start

December 1, 2016

Primary Completion

December 1, 2016

Study Completion

February 1, 2018

Last Updated

June 22, 2022

Record last verified: 2022-06