Clinicopathological Analysis of Factors Associated With the Development of Adverse Events During Physical Therapy Intervention in Neurocritical Patients in the Intensive Care Unit
Sponsor study identifier
observational
47
1 country
2
Study Start
September 23, 2026
Actual (reported)Primary Completion
October 31, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
October 31, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The goal of this observational study is to identify the clinical, neurological, hemodynamic, and respiratory variables associated with the occurrence of adverse events during physical therapy interventions in adult neurocritical patients admitted to the Intensive Care Unit (ICU). The main questions it aims to answer are: What clinical, neurological, hemodynamic, and respiratory factors are associated with adverse events during physical therapy in neurocritical patients? What is the incidence and type of adverse events that occur most frequently during physical therapy in this patient population? Researchers will compare clinical and physiological data between patients who experienced adverse events during physical therapy and those who did not, to determine risk factors associated with these complications. Participants' data will be retrospectively collected from medical records without performing new clinical interventions.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 31, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 23, 2026
Actual (reported)October 21, 2026
Actual (reported)October 28, 2026
Actual (reported)October 31, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
October 31, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Incidence of Adverse Events During Physical Therapy
Presence or absence of any adverse event (binary variable: Yes/No) occurring during or immediately following a physical therapy session in adult neurocritical ICU patients. Adverse events include: hypotension (drop in SBP \> 20 mmHg), hypertension, tachycardia, bradycardia, oxygen desaturation, acute neurological deterioration, increase in intracranial pressure (ICP), or decrease in cerebral perfusion pressure (CPP) requiring therapy session suspension.
During the physical therapy session (from initiation up to immediate post-session evaluation, up to 1 hour per session).
Clinical and Physiological Predictors of Adverse Events
Baseline assessment immediately prior to each physical therapy session.
Adult neurocritical ICU patients who presented at least one adverse event (e.g., hypotension, hypertension, tachycardia, bradycardia, oxygen desaturation, increased ICP, decreased CPP, acute neurological deterioration) during the physical therapy intervention.
Adult neurocritical ICU patients who underwent physical therapy intervention without experiencing any adverse events during the session.
Physical therapy and mobilization procedures administered to neurocritical patients during their ICU stay as recorded in medical, nursing, and physical therapy notes. Retrospective data collection evaluates baseline clinical-pathological risk profile and monitoring parameters (hemodynamics, neurological, respiratory).
Medical records of adult neurocritical patients admitted to the Intensive Care Unit (ICU) at a tertiary hospital in Querétaro, Mexico, who received physical therapy interventions between October 2023 and April 2026.
Hospital H+ Querétaro, Santiago de Querétaro, Querétaro
Querétaro City, Querétaro, Mexico
Hospital H+ Querétaro, Santiago de Querétaro, Querétaro
Querétaro, Mexico
First Submitted
October 21, 2026
First Posted
October 28, 2026
Study Start
September 23, 2026
Actual (reported)Primary Completion
October 31, 2026
EstimatedFrequency and Specific Types of Adverse Events
During each physical therapy session throughout the ICU stay (retrospectively evaluated from October 2023 to April 2026).
Comparative Analysis of Hemodynamic versus Respiratory Variables
Retrospective evaluation spanning the total ICU stay for each patient record (October 2023 to April 2026).
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Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
October 31, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 28, 2026
Record last verified: 2026-10
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