Hemoglobin Trends as a Predictor of Outcomes in Critically Ill Patients (The TRENT-ICU Study)

NCT07761832 | Completed

• 1 other identifier: CEI2026-30/04/V1
• Study Type: observational
• Target: 128
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to evaluate if early absolute hemoglobin decline (during the first 24 hours of admission) can predict prolonged intensive care unit stay (8 days or more) and in-hospital mortality in critically ill adult patients. The main questions it aims to answer are: Does absolute hemoglobin decline during the first 24 hours of admission independently predict prolonged intensive care unit stay in critically ill adult patients? Does absolute hemoglobin decline during the first 24 hours of admission independently predict in-hospital mortality in critically ill adult patients? Participants will: Have their routine clinical and laboratory data reviewed retrospectively from their electronic health records (including baseline hemoglobin and a second hemoglobin determination approximately 24 hours after admission). No additional interventions or extra blood draws will be performed beyond routine clinical care.

Conditions

Critical Illness; Anemia

Keywords

critical care; Hemoglobins; Blood Transfusion; Prognosis; Intensive Care Units

Outcome Measures

Primary Outcomes (1)

• Prolonged Intensive Care Unit Stay

  Incidence of prolonged intensive care unit (ICU) length of stay, defined a priori as an ICU stay equal to or greater than 8 days.

  From ICU admission up to 28 days

Secondary Outcomes (1)

• In-Hospital Mortality

  From ICU admission up to 30 days

Study Arms (1)

Critically Ill Adult Patients

Adult patients admitted to the intensive care unit with an ICU stay of more than 48 hours and at least two hemoglobin determinations obtained approximately 24 hours apart during routine care.

Other: Early Absolute Hemoglobin Decline

Interventions

Early Absolute Hemoglobin Decline OTHER

Measurement of the absolute difference in hemoglobin concentration (g/dL) between baseline ICU admission and approximately 24 hours post-admission. Data was collected retrospectively from electronic health records.

Critically Ill Adult Patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

dult patients admitted to the Intensive Care Unit at Hospital H+ Querétaro, Mexico, between January 2024 and January 2026, who required an ICU stay of more than 48 hours and had serial hemoglobin measurements during routine medical care.

You may qualify if:

• Adult patients (aged 18 years or older) admitted to the Intensive Care Unit (ICU) between January 2024 and January 2026.
• ICU length of stay greater than 48 hours.
• At least two hemoglobin determinations obtained with an interval of approximately 24 hours apart during routine medical care.

You may not qualify if:

• Massive bleeding upon ICU admission.
• Massive transfusion protocol activation.
• Pregnancy.
• Hemoglobinopathies.
• Active hemolytic anemia.
• Medical records with insufficient information for analysis.

Sponsors & Collaborators

• Hospital H+ Queretaro: lead

Study Sites (1)

Hospital H+ Querétaro, Santiago de Querétaro, Querétaro

Querétaro City, Querétaro, 76000, Mexico

Location

MeSH Terms

Conditions

Critical Illness; Anemia

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Hematologic Diseases; Hemic and Lymphatic Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 3, 2026
• First Posted: August 12, 2026
• Study Start: July 31, 2026
• Primary Completion: July 31, 2026
• Study Completion: July 31, 2026
• Last Updated: August 12, 2026

Record last verified: 2026-08

Locations

ME (1)