NCT07900022|Completed
Ozonated Olive Oil for Mini-Screw Complications in Molar Intrusion
Effect of Ozonated Olive Oil on Mini-Screw Complications During Orthodontic Treatment Combined With Molar Intrusion
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Effect of Ozonated Olive Oil on Mini-Screw Complications During Orthodontic Treatment Combined With Molar Intrusion
Sponsor study identifier
interventional
26
1 country
2
Study Start
December 20, 2021
Actual (reported)Primary Completion
February 7, 2022
Actual (reported)Study Completion
April 25, 2022
Actual (reported)The goal of this clinical trial was to learn whether ozonated olive oil can reduce complications around orthodontic mini-screws in patients with anterior open bite who receive maxillary molar intrusion as part of fixed orthodontic treatment. The study also compared ozonated olive oil with chlorhexidine, the antiseptic most commonly used for this purpose. The main questions it aimed to answer were:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 25, 2022
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 20, 2021
Actual (reported)February 7, 2022
Actual (reported)April 25, 2022
Actual (reported)October 20, 2026
Actual (reported)October 28, 2026
Actual (reported)Bleeding Index Around Mini-Screws
Bleeding index recorded around buccal and palatal mini-screws on the ozonated olive oil and chlorhexidine sides.
Day 0 (mini-screw placement), day 7, day 14 and day 21
Plaque Index Around Mini-Screws
Plaque index recorded around buccal and palatal mini-screws on the ozonated olive oil and chlorhexidine sides.
Day 0 (mini-screw placement), day 7, day 14 and day 21
Mini-Screw Mobility
Mini-screw mobility measured with Periotest M device (scale from -8 to +50; lower values indicate greater stability).
Day 0 (mini-screw placement), day 7, day 14 and day 21
Mini-screws and adjacent teeth on one randomly assigned side of the maxilla treated with ozonated olive oil spray (Arifoglu), 10 sprays per day for 7 days after mini-screw placement.
Mini-screws and adjacent teeth on the contralateral side of the maxilla treated with 0.2% chlorhexidine gluconate oral spray (Kloroben), 10 sprays per day for 7 days after mini-screw placement.
Ozonated olive oil oral spray (50 mL) applied to the mini-screw sites on the assigned side, 10 sprays per day for 7 days after mini-screw placement.
0.2% chlorhexidine gluconate oral spray (Kloroben) applied to the mini-screw sites and adjacent teeth on the contralateral side of the maxilla, 10 sprays per day for 7 days after mini-screw placement. Serves as the active comparator in this split-mouth design.
Van Yuzuncu Yil University, Faculty of Dentistry
Van, Van, (650) 00_-____, Turkey (Türkiye)
Van Yuzuncu Yil University, Faculty of Dentistry
Van, Van, 65100, Turkey (Türkiye)
26 participants (actual enrollment reported by the registry).
First Submitted
October 20, 2026
First Posted
October 28, 2026
Study Start
Probing Pocket Depth of Teeth Adjacent to Mini-Screws
Baseline (before treatment), day 0, day 7, day 14 and day 21
Plaque and Bleeding Indices of Teeth Adjacent to Mini-Screws
Baseline (before treatment), day 0, day 7, day 14 and day 21
Mobility of Teeth Adjacent to Mini-Screws
Baseline (before treatment), day 0, day 7, day 14 and day 21
Contact the study team to confirm eligibility.
December 20, 2021
Actual (reported)Primary Completion
February 7, 2022
Actual (reported)Study Completion
April 25, 2022
Actual (reported)Last Updated
October 28, 2026
Record last verified: 2026-10
Individual participant data will not be shared publicly due to participant privacy. De-identified data may be made available by the corresponding author upon reasonable request.
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Source: ClinicalTrials.gov.
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