Chlorhexidine Versus N-Asetil Sistein Irrigation in Mandibular Molar Teeth with Chronic Apical Periodontitis

NCT06834711 | Completed DMC

• 1 other identifier: 13.02.2025/152
• Study Type: interventional
• Target: 78
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical study was to evaluate the effect of using different irrigation solutions in the final irrigation of root canal treatment procedures on the intensity of postoperative pain and periapical tissue healing in patients presenting with mandibular molars with chronic apical periodontitis. The main question it aims to answer is: \- Does controlled irrigation with chlorhexidin and N-asetil sistein in root canal treatment reduce the severity of postoperative pain? In the chlorhexidin group, unlike the control group, each root canal was irrigated with 3 mL %2 chlorhexidin solution in the final irrigation. In the N-asetil sistein group, unlike the control group, each root canal was irrigated with 3 mL 200 mg/ml N-asetil sistein solution in the final irrigation.

Conditions

Chronic Apical Periodontitis

Keywords

chronic apical periodontitis; postoperative pain; N-asetil sistemin; chlorhexidin

Outcome Measures

Primary Outcomes (1)

• Visual Analogue Scale

  The visual analog scale for pain is a straight line with one end meaning no pain (0) and the other end meaning the worst pain (10) imaginable. A patient marks a point on the line that matches the amount of pain he or she feels. It may be used to help choose the right dose of pain medicine. Also called VAS.

  up to 72 hours

Study Arms (3)

Control Group

NO INTERVENTION

During root canal preparation, each canal was irrigated with a total of 18 ml of 2.5% sodium hypochlorite (NaOCl). In the final irrigation, each root canal was irrigated with 3 ml of 17% ethylene diamine tetra-acetic acid (EDTA) for 1 minute, followed by 5 ml of distilled water. Then, 5 ml of 2.5% NaOCl was irrigated, and finally 5 ml of distilled water was used.

Chlorhexidine Group

EXPERIMENTAL

During root canal preparation, each canal was irrigated with a total of 18 ml of 2.5% NaOCl. In the final irrigation, each root canal was irrigated with 3 ml of 17% ethylene diamine tetra-acetic acid (EDTA) for 1 minute, followed by 5 ml of distilled water. Then, each canal was irrigated with 3 ml of 2% chlorhexidine (CHX) and finally 5 ml of distilled water was used.

Drug: Chlorhexidine

N-asetil Sistein Group

EXPERIMENTAL

During root canal preparation, each canal was irrigated with a total of 18 ml of 2.5% NaOCl. In the final irrigation, each root canal was irrigated with 3 ml of 17% ethylene diamine tetra-acetic acid (EDTA) for 1 minute, followed by 5 ml of distilled water. Then, each canal was irrigated with 3 ml of N-acetyl Cysteine (NAC) (200 mg/ml) and finally 5 ml of distilled water was used.

Drug: N-Acetyl Cysteine

Interventions

N-Acetyl Cysteine DRUG

The root canals were irrigated with 3 mL N-acetyl Cysteine (NAC)(200 mg/ml) in N-acetyl Cysteine group in the final irrigation.

N-asetil Sistein Group

Chlorhexidine DRUG

The root canals were irrigated with 3 ml %2 chlorhexidine in chlorhexidin group in the final irrigation.

Chlorhexidine Group

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Mandibular permanent molars with chronic apical periodontitis
• Teeth with periapical index (PAI) score greater than 2
• Teeth with periodontal pocket depth less than 3 mm
• Patients without systemic disease (ASA 1-2)

You may not qualify if:

• Patients who have used analgesic, anti-inflammatory or opioid drugs in the last 7 days or antibiotics in the last 3 months
• Patients who report pregnancy, lactation or psychiatric disorders
• Teeth with a history of root canal treatment, sinus tract or abscess, and teeth planned for prosthetic restoration

Sponsors & Collaborators

• Cukurova University: lead

Study Sites (1)

Cukurova University

Adana, Sarıçam, 01250, Turkey (Türkiye)

Location

Related Publications (2)

• Corazza BJM, Martinho FC, Khoury RD, Toia CC, Orozco EIF, Prado RF, Machado FP, Valera MC. Clinical influence of calcium hydroxide and N-acetylcysteine on the levels of resolvins E1 and D2 in apical periodontitis. Int Endod J. 2021 Jan;54(1):61-73. doi: 10.1111/iej.13403. Epub 2020 Oct 3.

  PMID: 32896000 BACKGROUND

• Comparative evaluation of N-acetylcysteine and chlorhexidine as final irrigation on the push-out bond strength of different sealers: An in vitro study

  BACKGROUND

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Acetylcysteine; Chlorhexidine

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Cysteine; Amino Acids, Sulfur; Sulfur Compounds; Organic Chemicals; Amino Acids; Amino Acids, Peptides, and Proteins; Biguanides; Guanidines; Amidines

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Cukurova University, Faculty of Dentistry

Study Record Dates

• First Submitted: February 14, 2025
• First Posted: February 19, 2025
• Study Start: February 15, 2024
• Primary Completion: December 12, 2024
• Study Completion: January 5, 2025
• Last Updated: February 20, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)